85677-93-6

• 常用中文名：2,6-二甲基-4-(3-硝基苯基)-3,5-吡啶二甲酸 2-甲氧基乙基 异丙基酯
• 常用英文名：Dehydro NiModipine
• CAS号：85677-93-6
• 分子式：C₂₁H₂₄N₂O₇
• 分子量：416.42400
• 相关类别： 医药中间体 杂环化合物 吡啶类化合物 乙基吡啶
• 发布时间：2018-12-23 20:56:59
• 更新时间：2026-07-17 20:39:29

名称

• 中文名: 2,6-二甲基-4-(3-硝基苯基)-3,5-吡啶二甲酸 2-甲氧基乙基 异丙基酯
• 英文名: Isopropyl 2-methoxyethyl 2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyrid inedicarboxylate
• 中文别名: 尼莫地平相关杂质; 尼莫地平A; 尼莫地平杂质Ⅰ 2,6-二甲基-4-（3-硝基苯基）-3,5-吡啶二甲酸-2-甲氧乙酯异丙酯; 尼莫地平杂质A 标准品; 尼莫地平杂质A; 2,6-二甲基-4-(3-硝基苯基)-3,5-吡啶二甲酸-2-甲氧基乙酯异丙酯; 尼莫地平杂质Ⅰ 2,6-二甲基-4-(3-硝基苯基)-3,5-吡啶二甲酸-2-甲氧乙酯异丙酯; 3-异丙基 5-(2- 甲氧基乙基) 2,6-二甲基-4-(3-硝基苯基)吡啶-3,5-二羧酸盐 (尼莫地平杂质); 尼莫地平杂质A(尼莫地平相关化合物A); 尼莫地平相关物质A; 尼莫地平相关化合物A; 尼莫地平杂质A/BP); 尼莫地平杂质A/二甲氧基-1-甲基乙基-2,6-二甲基-4-(3-硝基苯基)吡啶-3,5-二甲酸; 尼莫地平杂质1; 尼莫地平脱氢杂质; 尼莫地平相关物质A 标准品; 脱氢尼莫地平; 尼莫地平杂质01; 去氢尼莫地平; 二甲氧基-1-甲基乙基-2,6-二甲基-4-(3-硝基苯基)吡啶-3,5-二甲酸
• 英文别名: Nimodipine Impurity A (Nimodipine Related Compound A); NIMODIPINE RELATED COMPOUND A (50 MG) (2-METHOXYETHYL 1-METHYLETHYL 2,6-DIMETHYL-4-(3-NITROPHENYL)PYRIDINE-3,5-DICBOXYLATE) ISO 9001：2015 REACH; Nimodipine Related Compound A (50 mg) (2-methoxyethyl 1-methylethyl 2,6-dimethyl-4-(3-nitrophenyl)pyridine-3,5-dicboxylate); Nimodipine Impurity Ⅰ (2-methoxyethyl-1-methylethyl -2,6-dimethyl-4-(3-nitrophenyl )pyridine-3,5-dicboxylate); 3,5-Pyridinedicboxylic acid, 2,6-dimethyl-4-(3-nitrophenyl)-, 3-(2-methoxyethyl) 5-(1-methylethyl) ester; Nimodipine Impurity; 2-Methoxyethyl 1-Methylethyl 2,6-Di; 3-isopropyl 5-(2-methoxyethyl) 2,6-dimethyl-4-(3-nitrophenyl)pyridine-3,5-dicboxylate; Nimodipine Impurit Ⅰ:2,6-Dimethyl-4-(3-nitrophenyl)- 3,5-pyridinedicboxylic Acid 2-Methoxyethyl 1-Methylethyl Ester( Dehydro Nimodipine); Nimodipine impurity A CRS; 2,6-Dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicboxylic acid isopropyl 2-methoxyethyl ester; 2,6-Dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicboxylic acid 2-methoxyethyl 1-methylethyl ester; Nimodipine Oxidized; Nimodipine Imp A; Nimodipine Related Compound A; Nimodipine Impurity A; 2-Methoxyethyl 1-Methylethyl 2,6-diMethyl-4-(3-nitrophenyl)pyridine-3,5-dicboxylate; Isopropyl 2-methoxyethyl 2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyrid inedicboxylate; 2,6-Dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid 2-methoxyethyl 1-methylethyl ester; Nimodipine Related Compound A (2-methoxyethyl-1-methylethyl 2,6-dimethyl-4-(3-nitrophenyl)pyridine; (RS)-2,6-Dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicboxylic acid, isopropyl, 2-methoxyethyl ester; 3-Isopropyl 5-(2-methoxyethyl) 2,6-dimethyl-4-(3-nitrophenyl)pyridine-3,5-dicboxylate (Nimodipine Impurity); 3,5-Pyridinedicboxylic acid, 2,6-dimethyl-4-(3-nitrophenyl)-, 2-methoxyethyl 1-methylethyl ester; Nimodipine Related Compound A (50 mg); Nimodipine Impurity 1; Nimodipine impurity A (N0850010)

物化性质

• 密度: 1.221±0.06 g/cm3
• 分子式: C₂₁H₂₄N₂O₇
• 分子量: 416.42400
• 精确质量: 416.15800
• PSA: 120.54000
• LogP: 4.16520
• 水溶解性: Practically insoluble (0.046 g/L) (25 ºC)

安全

• 危险品运输编码: NONH for all modes of transport

合成路线

66085-59-4 ~70% 85677-93-6

文献：Boecker, Ronald H.; Guengerich, F. Peter Journal of Medicinal Chemistry, 1986 , vol. 29, # 9 p. 1596 - 1603

1333-82-0 66085-59-4 ~% 85677-93-6

文献：US4705794 A1, ;

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