103460-89-5

• 常用中文名：8-氟代加替沙星
• 常用英文名：8-DeMethoxy-8-fluoro Gatifloxacin
• CAS号：103460-89-5
• 分子式：C₁₈H₁₉F₂N₃O₃
• 分子量：363.359
• 发布时间：2018-12-04 17:10:13
• 更新时间：2026-08-14 19:38:56

名称

• 中文名: 1-环丙基-6,8-二氟-7-(3-甲基哌嗪-1-基)-4-氧代-1,4-二氢喹啉-3-羧酸
• 英文名: 1-cyclopropyl-6,8-difluoro-7-(3-methylpiperazin-1-yl)-4-oxoquinoline-3-carboxylic acid
• 中文别名: 加替沙星杂质; 加替沙星杂质4; 1-环丙基-6,8-二氟-1,4-二氢-7-(3-甲基-1-哌嗪基)-4-氧代-3-喹啉羧酸; 8-氟-加替沙星; 1-环丙基-6,8-二氟-7-(3-甲基哌嗪-1-基)-4-氧代-1,4-二氢喹啉-3-甲酸; 8-去甲氧基-8-氟加替沙星
• 英文别名: 1-Cyclopropyl-6,8-difluoro-1,4-dihydro-7-(3-Methyl-1-piperazinyl)-4-oxo-3-quinolinecboxylic Acid; 1-cyclopropyl-6,8-difluoro-7-(3-methylpiperazin-1-yl)-4-oxoquinoline-3-cboxylic acid; Gatifloxacin Desmethoxy 8-Fluoro; 1-Cyclopropyl-6,8-difluoro-7-(3-methylpiperazinyl)-4-oxohydroquinoline-3-carboxylic acid; Gatifloxacin Impurity 4; 1-cyclopropyl-6,8-fluoro-1,4-dihydro-7-(3-Methyl-1-piperazinyl)-4-oxo-3-Quinolinecboxylic acid; 8-Fluoro Gatifloxacin; 8-Fluoro Gatifloxacin，1-Cyclopropyl-6,8-difluoro-1,4-dihydro-7-(3-methyl-1-piperazinyl)-4-oxo-3-quinolinecboxylic acid; AMQ 2; Gatifloxacin Impurity1375; 1-cyclopropyl-6,8-difluoro-7-(3-Methylpiperazin-1-yl)-4-oxo-1,4-dihydroquinoline-3-cboxylic acid; AMQ2; Pirtobrutinib Impurity 11; 3-Quinolinecboxylicacid, 1-cyclopropyl-6,8-difluoro-1,4-dihydro-7-(3-Methyl-1-piperazinyl)-4-oxo; 1-Cyclopropyl-6,8-difluoro-1,4-dihydro-4-oxo-7-(3-methylpiperazine-1-yl) quinolone-3-cboxy acid; 1-Cyclopropyl-6,8-difluoro-1,4-dihydro-7-(3-methyl-piperazin-1-yl)-4-oxo-quinolin-3-cboxylic acid; 8-Demethoxy-8-fluoro Gatifloxacin; 8-Demethoxy-8-Fuoro Gatifloxacin; 1-Cyclopropyl-6,8-difluoro-7-(3-methyl-1-piperazinyl)-4-oxo-1,4-dihydro-3-quinolinecarboxylic acid

物化性质

• 密度: 1.4±0.1 g/cm3
• 沸点: 566.9±50.0 °C at 760 mmHg
• 分子式: C₁₈H₁₉F₂N₃O₃
• 分子量: 363.359
• 闪点: 296.7±30.1 °C
• 精确质量: 363.139435
• PSA: 74.57000
• LogP: 1.55
• 蒸汽压: 0.0±1.6 mmHg at 25°C
• 折射率: 1.618
• 储存条件: 2-8°C，避光，保存于惰性气体中

安全

• 海关编码: 2933990090

合成路线

94695-52-0 109-07-9 ~74% 103460-89-5

文献：Domagala; Bridges; Culbertson; Gambino; Hagen; Karrick; Porter; Sanchez; Sesnie; Spense; Szotek; Wemple Journal of Medicinal Chemistry, 1991 , vol. 34, # 3 p. 1142 - 1154

上下游产品

上游产品  2
94695-52-0 109-07-9
下游产品  1
160738-57-8

海关

海关编码	2933990090
中文概述	2933990090. 其他仅含氮杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
申报要素	品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期
Summary	2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%