80653-76-5

• 常用中文名：Maleimide, 4-hydroxy-3-(2-(pyridyl)-4-thiazolyl)-
• 常用英文名：Maleimide, 4-hydroxy-3-(2-(pyridyl)-4-thiazolyl)-
• CAS号：80653-76-5
• 分子式：C₁₂H₇N₃O₃S
• 分子量：273.26700
• 发布时间：2017-02-09 08:40:34
• 更新时间：2024-04-03 12:23:42

名称

• 英文名: 3-hydroxy-4-(2-pyridin-4-yl-1,3-thiazol-4-yl)pyrrole-2,5-dione
• 英文别名: 1H-Pyrrole-2,5-dione,4-hydroxy-3-(2-(pyridyl)-4-thiazolyl); Maleimide,4-hydroxy-3-(2-(pyridyl)-4-thiazolyl); 4-Hydroxy-3-(2-(pyridyl)-4-thiazolyl)-1H-pyrrole-2,5-dione; 5-hydroxy-4-(2-pyridin-4-yl-1,3-thiazol-4-yl)-1H-pyrrole-2,3-dione; 3-Hydroxy-4-[2-(4-pyridyl)thiazol-4-yl]-3-pyrroline-2,5-dione

物化性质

• 密度: 1.613g/cm3
• 分子式: C₁₂H₇N₃O₃S
• 分子量: 273.26700
• 精确质量: 273.02100
• PSA: 123.91000
• LogP: 1.40650
• 折射率: 1.719

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : UX9626500 CHEMICAL NAME : 1H-Pyrrole-2,5-dione, 4-hydroxy-3-(2-(pyridyl)-4-thiazolyl)- CAS REGISTRY NUMBER : 80653-76-5 LAST UPDATED : 199612 DATA ITEMS CITED : 2 MOLECULAR FORMULA : C12-H7-N3-O3-S MOLECULAR WEIGHT : 273.28 WISWESSER LINE NOTATION : T6NJ D- BT5N CSJ E- DTVMVJ EQ HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 5 gm/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 26,700,1983 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 531 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 26,700,1983

合成路线

31112-96-6 95-92-1 ~44% 80653-76-5

文献：Rooney; Randall; Streeter; Ziegler; Cragoe Jr.; Schwam; Michelson; Williams; Eichler; Duggan; Ulm; Noll Journal of Medicinal Chemistry, 1983 , vol. 26, # 5 p. 700 - 714

2196-13-6 ~% 80653-76-5

文献：Rooney; Randall; Streeter; Ziegler; Cragoe Jr.; Schwam; Michelson; Williams; Eichler; Duggan; Ulm; Noll Journal of Medicinal Chemistry, 1983 , vol. 26, # 5 p. 700 - 714

80653-68-5 ~% 80653-76-5

文献：Rooney; Randall; Streeter; Ziegler; Cragoe Jr.; Schwam; Michelson; Williams; Eichler; Duggan; Ulm; Noll Journal of Medicinal Chemistry, 1983 , vol. 26, # 5 p. 700 - 714

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