817204-32-3

• 常用中文名：(2'R)-N-苯甲酰基-2'-脱氧-2'-氟-2'-甲基胞苷 3',5'-二苯甲酸酯
• 常用英文名：(2'R)-N-Benzoyl-2'-deoxy-2'-fluoro-2'-methylcytidine 3',5'-dibenzoate
• CAS号：817204-32-3
• 分子式：C₃₁H₂₆FN₃O₇
• 分子量：571.552
• 相关类别： 医药中间体 原料药中间体
• 发布时间：2018-12-13 12:10:41
• 更新时间：2026-07-07 14:58:37

名称

• 中文名: (2'R)-N-苯甲酰基-2'-脱氧-2'-氟-2'-甲基胞苷 3',5'-二苯甲酸酯
• 英文名: (2'R)-N-Benzoyl-2'-deoxy-2'-fluoro-2'-methylcytidine 3',5'-dibenzoate
• 中文别名: (2'R)-N-苯甲酰基-2'-脱氧-2'-氟-2'-甲基胞苷 3',5'-二苯甲酸酯(索非布韦中间体-7); 索菲布韦中间体2; 索弗布韦中间体SF-1; ((2S,3S,4S,5S)-5-(4-苯甲酰胺-2-氧代嘧啶-1(2H)-基)-2-((苯甲酰氧基)甲基-4-氟-4-甲基四氢呋喃-3-基)苯甲酸酯; N-苯甲酰基-2‘-氟-2'-脱氧-2'-甲基胞苷 3',5'-二苯甲酸酯; 化合物 (2R,3R,4R,5R)-5-(4-BENZAMIDO-2-OXOPYRIMIDIN-1(2H)-YL)-2-((BENZOYLOXY)METHYL)-4-FLUORO-4-METHYLTETRAHYDROFURAN-3-YL BENZOATE; (2R,3R,4R,5R)-5-(4-苯甲酰氨基-2-氧亚基-1,2-二氢嘧啶-1-基)-3-(苯甲酰氧基)-4-氟-4-甲基噁戊环-2-基]甲基苯酸盐; 索非布韦杂质69; 索氟布韦中间体SF-C3; (2R,3R,4R,5R)-5-(4-苯甲酰氨基-2-氧代嘧啶-1(2H)-基)-2-((苯甲酰氧基)甲基)-4-氟-4-甲基四氢呋喃-3-基苯甲酸酯; PSI 6206中间体; (2'R)-N-苯甲酰基-2'-脱氧-2'-氟-2'-甲基胞苷-3',5'-二苯甲酸酯; (2R,3R,4R,5R)-2-[(苯甲酰基氧基)甲基]-4-氟-4-甲基-5-[2-氧代-4-苯甲酰氨基嘧啶-1(2H)-基]-3-四氢呋喃基苯甲酸酯; (2'R)-N-苯甲酰基-2'-脱氧-2'-氟-2'-甲基胞苷 3',5'-二苯甲酸酯(索非布韦中间体3); (2'R)-N-苯甲酰基-2'-脱氧-2'-氟-2'-甲基胞苷 3',5'-二苯甲酸酯(索非布韦中间体3)817-3; 湖北励合,索非布韦中间体817-3; 索非布韦中间体1; 索非布韦中间体2; 索福斯布韦杂质D; 索氟布韦杂质16; 索非布韦12; 索非布韦中间体6; 呋喃核糖基嘧啶核苷; (2'R)-N-苯甲酰基-2'-脱氧-2'-氟-2'-甲基胞苷 3',5'-二苯甲酸酯(索非布韦中间体); 索氟布韦 中间体 SF-3; 索磷布韦中间体; 索氟布韦 中间体 SF-C3; (2'R)-N-苯甲酰基-2'脱氧-2'-氟-2; 索非布韦杂质16; 索非布韦原料1; 索非布韦IMP-5; 索氟布韦 中间体2
• 英文别名: PSI-6130 derivative; Cytidine, N-benzoyl-2'-deoxy-2'-fluoro-2'-methyl-, 3',5'-dibenzoate, (2'R)- (9CI, ACI); 2'-Defluro-2'-methylene Sofosbuvir; N-BENZOYL-2'-DEOXY-2'-FLUORO-2METHYL-3'5'-DIBENZOATE(2R); (2'R)-N-Benzoyl-2'-deoxy-2'-fluoro-2'-methylcytidine 3',5'-d; Cytidine, N-benzoyl-2'-deoxy-2'-fluoro-2'-methyl-, 3',5'-dibenzoate; 4-(Benzoylamino)-1-[5-O-benzoyl-2-deoxy-2-fluoro-2-methyl-3-O-(ph enoxycarbonyl)-β-D-xylofuranosyl]-2(1H)-pyrimidinone; N-Benzoyl-3',5'-di-O-benzoyl-2'-deoxy-2'-fluoro-2'-methylcytidine; (2R,3R,4R,5R)-5-[4-Benzamido-2-oxopyrimidin-1(2H)-yl]-2-[(benzoyloxy)methyl]-4-fluoro-4-methyl-3-tetrahydrofuranyl Benzoate; SF-3; (2R,3R,4R,5R)-5-(4-benzaMido-2-oxopyriMidin-1(2H)-yl); (2R,3R,4R,5R)-5-(4-benzaMido-2-oxopyriMidin-1(2H)-yl)-2-((benzoyloxy)Methyl)-4-fluoro-4-Methyltetrahydrofuran-3-yl benzoate; (2'R)-N-Bz-2'-deoxy-2'-F-2'-Methylcytidine 3',5'-dibenzoate; Sofosbuvir Benzoyl Cytidine; methyl-3’ PSI-6130 derivative ISO 9001：2015 REACH; N4,3',5'-tri-O-benzoyl-2'-deoxy-2'-fluoro-2'-C-methylcytidine; (2'R)-N-Benzoyl-2'-deoxy-2'-fluoro-2'-methyl-3',5'-dibenzoate Cytidine; Sofosbuvir Impurity 69; methyl-, 3'; O3',O5'-ditrityl-uridine; Sofosbuvir Tri benzoyl fluoro cytidine; 3',5'-O-4-Tribenzoyl-2'-deoxy-2'-fluoro-2'-C-Methylcytidine; Sofosbuvir imp-5; N-benzoyl-2'-deoxy-2'-fluoro-2'-methyl-,3',5'-dibenzoate,(2'R)Cytidine; N4-benzoyl-3',5'-di-O-benzoyl-2'-fluoro-2'-C-methylcytidine; N4,3',5'-tri-O-benzoyl-2'-deoxy-2'-fluoro-2'-C-Methylcytidine; [(2R,3R,4R,5R)-5-(4-benzamido-2-oxo-1,2-dihydropyrimidin-1-yl)-3-(benzoyloxy)-4-fluoro-4-methyloxolan-2-yl]methyl benzoate; (2R,3R,4R,5R)-5-(4-Benzamido-2-oxopyrimidin-1(2H)-yl)-2-((benzoyloxy)methyl)-4-fluoro-4-methyltetrahydrofuran-3-yl benzoate(2R,3R,4R,5R)-5-(4-Benzamido-2-oxopyrimidin-1(2H)-yl)-2-((benzoyloxy)methyl)-4-fluoro-4-methyltetrahydrofuran-3-yl benzoate; 3',5'-ditrityluridine; 2'-Deoxy-2'-fluoro-2'- Methyl-N-(phenylcbonyl) cytidine; Cytidine, N-benzoyl-2'; 3',5'-di-O-trityluridine; 2'-Deoxy-2'-fluoro-2'- Methyl-N-(phenylcbonyl) cytidine (N-3); Cytidine, N-benzoyl-2'-deoxy-2'-fluoro-2'-Methyl-, 3',5'-dibenzoate, (2'R); ((2r,3s,4r,5r)-5-(4-benzamido-2-oxopyrimidin-1(2h)-yl)-4-fluoro-4-methyl-3-((phenoxycbonyl)oxy)tetrahydrofuran-2-yl)methyl benzoate; Cytidine, N-benzoyl-2'-deoxy-2'-fluoro-2'-methyl-, 3',5'-dib; Sofibute 12; Sofosbuvir INT 2; 3',5'-O-ditrityluridine; Sofosbuvir Intermediate 2; Bz-PSI-6130; InterMediate of Sofosbuir; dibenzoateCytidine; dibenzoate,(2'; 3',5'-Di-O-Trityl-uridin; R)-N-benzoyl-2’ 3',5'-Bis-triphenylmethyl-pyrimidin-ribosid; ((2R,3R,4R,5R)-5-(benzamido-2-oxopyrimidin-1(2H)-yl)-2-(benzoyloxymethyl)-4-fluoro-4-methyltetrahydrofuran-3-yl; Sofosbuvir int. N-3; PSI 6206 Intermediate; Sofosbuvir Intermediates1

物化性质

• 密度: 1.3±0.1 g/cm3
• 熔点: 241 ºC (dichloromethane/hexane)
• 分子式: C₃₁H₂₆FN₃O₇
• 分子量: 571.552
• 精确质量: 571.175476
• PSA: 125.82000
• LogP: 6.18
• 折射率: 1.628
• 储存条件: -20°C，干燥密封
• 水溶解性: Insuluble (3.0E-5 g/L) (25 ºC)

合成路线

上下游产品

上游产品  10
817204-33-4 98-88-4 863329-62-8 874638-93-4
85743-99-3 817204-30-1 817204-29-8 55775-39-8
874638-80-9 817204-31-2
下游产品  2
817204-33-4 863329-66-2