111218-73-6

• 常用中文名：1-(4-Amino-6-bromo-2-quinazolinyl)-4-(2-furanylcarbonyl)piperazine hyd rochloride
• 常用英文名：1-(4-Amino-6-bromo-2-quinazolinyl)-4-(2-furanylcarbonyl)piperazine hyd rochloride
• CAS号：111218-73-6
• 分子式：C₁₇H₁₇BrClN₅O₂
• 分子量：438.70600
• 发布时间：2016-03-20 11:54:54
• 更新时间：2024-01-10 10:33:28

名称

• 英文名: [4-(4-amino-6-bromoquinazolin-2-yl)piperazin-1-yl]-(furan-2-yl)methanone,hydrochloride

物化性质

• 沸点: 642.1ºC at 760mmHg
• 分子式: C₁₇H₁₇BrClN₅O₂
• 分子量: 438.70600
• 闪点: 342.1ºC
• 精确质量: 437.02500
• PSA: 89.22000
• LogP: 3.26490
• 蒸汽压: 2.22E-16mmHg at 25°C

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : TK8030300 CHEMICAL NAME : Piperazine, 1-(4-amino-6-bromo-2-quinazolinyl)-4-(2-furanylcarbon yl)-, monohydrochloride CAS REGISTRY NUMBER : 111218-73-6 LAST UPDATED : 199712 DATA ITEMS CITED : 1 MOLECULAR FORMULA : C17-H16-Br-N5-O2.Cl-H MOLECULAR WEIGHT : 438.75 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : >400 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : PCJOAU Pharmaceutical Chemistry Journal (English Translation). Translation of KHFZAN. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) No.1- 1967- Volume(issue)/page/year: 21,478,1987

合成路线

111218-89-4 40172-95-0 ~98% 111218-73-6

文献：Volzhina, O. N.; Azimov, V. A.; Medvedev, B. A.; Kazakov, A. A.; Zhikhareva, G. P.; et al. Pharmaceutical Chemistry Journal, 1987 , vol. 21, # 7 p. 478 - 483 Khimiko-Farmatsevticheskii Zhurnal, 1987 , vol. 21, # 7 p. 802 - 807

88145-89-5 ~% 111218-73-6

文献：Volzhina, O. N.; Azimov, V. A.; Medvedev, B. A.; Kazakov, A. A.; Zhikhareva, G. P.; et al. Pharmaceutical Chemistry Journal, 1987 , vol. 21, # 7 p. 478 - 483 Khimiko-Farmatsevticheskii Zhurnal, 1987 , vol. 21, # 7 p. 802 - 807

102393-82-8 ~% 111218-73-6

文献：Volzhina, O. N.; Azimov, V. A.; Medvedev, B. A.; Kazakov, A. A.; Zhikhareva, G. P.; et al. Pharmaceutical Chemistry Journal, 1987 , vol. 21, # 7 p. 478 - 483 Khimiko-Farmatsevticheskii Zhurnal, 1987 , vol. 21, # 7 p. 802 - 807

5794-88-7 ~% 111218-73-6

文献：Volzhina, O. N.; Azimov, V. A.; Medvedev, B. A.; Kazakov, A. A.; Zhikhareva, G. P.; et al. Pharmaceutical Chemistry Journal, 1987 , vol. 21, # 7 p. 478 - 483 Khimiko-Farmatsevticheskii Zhurnal, 1987 , vol. 21, # 7 p. 802 - 807