112668-45-8

• 常用中文名：4-amino-alpha,alpha-dimethyl-1H-imidazo(4,5-c)quinolin-1-ethanol
• 常用英文名：4-amino-alpha,alpha-dimethyl-1H-imidazo(4,5-c)quinolin-1-ethanol
• CAS号：112668-45-8
• 分子式：C₁₄H₁₆N₄O
• 分子量：256.30300
• 发布时间：2017-07-24 22:09:42
• 更新时间：2024-01-14 15:13:26

名称

• 英文名: 1-(4-aminoimidazo[4,5-c]quinolin-1-yl)-2-methylpropan-2-ol
• 英文别名: 4-amino-1-(2-hydroxy-2-methylpropyl)-1H-imidazo[4,5-c]quinoline; 2-Hydroxy Imiquimod; R 842; 1-(2,hydroxy-2-methylpropyl)-1H-imidazo[4,5-c]quinolin-4-amine; 1-(4-amino-1H-imidazo[4,5-c]quinolin-1-yl)-2-methylpropan-2-ol

物化性质

• 密度: 1.34g/cm3
• 沸点: 513.6ºC at 760 mmHg
• 分子式: C₁₄H₁₆N₄O
• 分子量: 256.30300
• 闪点: 264.4ºC
• 精确质量: 256.13200
• PSA: 77.69000
• LogP: 1.86770
• 蒸汽压: 2.26E-11mmHg at 25°C
• 折射率: 1.685

合成路线

129655-65-8 ~% 112668-45-8

文献：Riker Laboratories, Inc. Patent: US4689338 A1, 1987 ; US 4689338 A

200198-35-2 95-50-1 ~% 112668-45-8

文献：Minnesota Mining and Manufacturing Company Patent: US5741908 A1, 1998 ;

1375262-91-1 ~86% 112668-45-8

文献：Shi, Ce; Xiong, Zhengming; Chittepu, Padmaja; Aldrich, Courtney C.; Ohlfest, John R.; Ferguson, David M. ACS Medicinal Chemistry Letters, 2012 , vol. 3, # 6 p. 501 - 504

133860-77-2 ~% 112668-45-8

文献：Gerster, John F.; Lindstrom, Kyle J.; Miller, Richard L.; Tomai, Mark A.; Birmachu, Woubalem; Bomersine, Shannon N.; Gibson, Shiela J.; Imbertson, Linda M.; Jacobson, Joel R.; Knafla, Roy T.; Maye, Peter V.; Nikolaides, Nickolas; Oneyemi, Folakemi Y.; Parkhurst, Gwen J.; Pecore, Sharon E.; Reiter, Michael J.; Scribner, Lisa S.; Testerman, Tracy L.; Thompson, Natalie J.; Wagner, Tammy L.; Weeks, Charles E.; Andre, Jean-Denis; Lagain, Daniel; Bastard, Yvon; Lupu, Michel Journal of Medicinal Chemistry, 2005 , vol. 48, # 10 p. 3481 - 3491

15151-57-2 ~% 112668-45-8

文献：Gerster, John F.; Lindstrom, Kyle J.; Miller, Richard L.; Tomai, Mark A.; Birmachu, Woubalem; Bomersine, Shannon N.; Gibson, Shiela J.; Imbertson, Linda M.; Jacobson, Joel R.; Knafla, Roy T.; Maye, Peter V.; Nikolaides, Nickolas; Oneyemi, Folakemi Y.; Parkhurst, Gwen J.; Pecore, Sharon E.; Reiter, Michael J.; Scribner, Lisa S.; Testerman, Tracy L.; Thompson, Natalie J.; Wagner, Tammy L.; Weeks, Charles E.; Andre, Jean-Denis; Lagain, Daniel; Bastard, Yvon; Lupu, Michel Journal of Medicinal Chemistry, 2005 , vol. 48, # 10 p. 3481 - 3491

132521-66-5 ~% 112668-45-8

文献：Gerster, John F.; Lindstrom, Kyle J.; Miller, Richard L.; Tomai, Mark A.; Birmachu, Woubalem; Bomersine, Shannon N.; Gibson, Shiela J.; Imbertson, Linda M.; Jacobson, Joel R.; Knafla, Roy T.; Maye, Peter V.; Nikolaides, Nickolas; Oneyemi, Folakemi Y.; Parkhurst, Gwen J.; Pecore, Sharon E.; Reiter, Michael J.; Scribner, Lisa S.; Testerman, Tracy L.; Thompson, Natalie J.; Wagner, Tammy L.; Weeks, Charles E.; Andre, Jean-Denis; Lagain, Daniel; Bastard, Yvon; Lupu, Michel Journal of Medicinal Chemistry, 2005 , vol. 48, # 10 p. 3481 - 3491

133860-78-3 ~% 112668-45-8

文献：Gerster, John F.; Lindstrom, Kyle J.; Miller, Richard L.; Tomai, Mark A.; Birmachu, Woubalem; Bomersine, Shannon N.; Gibson, Shiela J.; Imbertson, Linda M.; Jacobson, Joel R.; Knafla, Roy T.; Maye, Peter V.; Nikolaides, Nickolas; Oneyemi, Folakemi Y.; Parkhurst, Gwen J.; Pecore, Sharon E.; Reiter, Michael J.; Scribner, Lisa S.; Testerman, Tracy L.; Thompson, Natalie J.; Wagner, Tammy L.; Weeks, Charles E.; Andre, Jean-Denis; Lagain, Daniel; Bastard, Yvon; Lupu, Michel Journal of Medicinal Chemistry, 2005 , vol. 48, # 10 p. 3481 - 3491

1375262-89-7 ~% 112668-45-8

文献：Shi, Ce; Xiong, Zhengming; Chittepu, Padmaja; Aldrich, Courtney C.; Ohlfest, John R.; Ferguson, David M. ACS Medicinal Chemistry Letters, 2012 , vol. 3, # 6 p. 501 - 504

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