125-69-9

• 常用中文名：氢溴酸右美沙芬
• 常用英文名：Dextromethorphan Hydrobromide
• CAS号：125-69-9
• 分子式：C₁₈H₂₆BrNO
• 分子量：352.309
• 发布时间：2018-09-29 12:11:35
• 更新时间：2024-01-02 10:09:29
• 用作中枢神经镇咳药

名称

• 中文名: 氢溴酸右美沙芬
• 英文名: Dextromethorphan Hydrobromide
• 中文别名: 3-甲氧基-17-甲基-(92,132,142)吗啡喃氢溴酸; 氢溴蒜右美沙芬
• 英文别名: tussade; Dextromethorphan hydrobromide anhydrous; d-3-methoxy-n-methylmorphinan hydrobromide; (1S,9S,10S)-4-methoxy-17-methyl-17-azatetracyclo[7.5.3.0.0]heptadeca-2,4,6-triene hydrobromide; BENYLIN; Dextromethorphan hydrobromide; morphinan, 3-methoxy-17-methyl-, (9a,13a,14a)-, hydrobromide (1:1); Dextromethorphan HBr; EINECS 204-750-1; (9α,13α,14α)-3-Methoxy-17-methylmorphinan hydrobromide; d-methorphan hydrobromide; (9alpha,13alpha,14alpha)-3-methoxy-17-methylmorphinan hydrobromide; morphinan, 3-methoxy-17-methyl-, (9α,13α,14α)-, hydrobromide; MFCD00269810; (9α,13α,14α)-3-Methoxy-17-methylmorphinan hydrobromide (1:1); Morphinan, 3-methoxy-17-methyl-, (9α,13α,14α)-, hydrobromide (1:1); tusilan; (9a,13a,14a)-3-methoxy-17-methylmorphinan hydrobromide (1:1)

物化性质

• 沸点: 486.1ºC at 760 mmHg
• 分子式: C₁₈H₂₆BrNO
• 分子量: 352.309
• 闪点: 247.8ºC
• 精确质量: 351.119781
• PSA: 12.47000
• LogP: 4.27940
• 蒸汽压: 2.92E-10mmHg at 25°C
• 储存条件: 室温
• 分子结构:

  1、 摩尔折射率：81.76

  2、 摩尔体积（cm³/mol）：243.8

  3、 等张比容（90.2K）：631.2

  4、 表面张力（dyne/cm）：44.9

  5、 极化率（10-24cm3）：32.41

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : QD0222000 CHEMICAL NAME : Morphinan, 3-methoxy-N-methyl-, hydrobromide, (+)- CAS REGISTRY NUMBER : 125-69-9 LAST UPDATED : 199603 DATA ITEMS CITED : 17 MOLECULAR FORMULA : C18-H25-N-O.Br-H MOLECULAR WEIGHT : 352.36 WISWESSER LINE NOTATION : T6 G666/FQ 2AF Q FX ONT&TTJ IO1 O &EH -R HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Human - child DOSE/DURATION : 30 mg/kg TOXIC EFFECTS : Behavioral - excitement Behavioral - changes in motor activity (specific assay) Behavioral - ataxia REFERENCE : PEDIAU Pediatrics. (American Academy of Pediatrics, P.O. Box 1034, Evanston, IL 60204) V.1- 1948- Volume(issue)/page/year: 59,117,1977 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Human - man DOSE/DURATION : 57 gm/kg/5Y-I TOXIC EFFECTS : Sense Organs and Special Senses (Eye) - effect, not otherwise specified Behavioral - hallucinations, distorted perceptions Behavioral - ataxia REFERENCE : AJEMEN American Journal of Emergency Medicine. (WB Saunders, Philadelphia, PA) V.1- 1983- Volume(issue)/page/year: 13,174,1995 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 350 mg/kg TOXIC EFFECTS : Sense Organs and Special Senses (Eye) - effect, not otherwise specified REFERENCE : JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 109,189,1953 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 423 mg/kg TOXIC EFFECTS : Behavioral - muscle contraction or spasticity REFERENCE : OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 6,1207,1972 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 165 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 109,189,1953 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 125 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : USXXAM United States Patent Document. (U.S. Patent Office, Box 9, Washington, DC 20231) Volume(issue)/page/year: #3031377 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 34 mg/kg TOXIC EFFECTS : Behavioral - somnolence (general depressed activity) Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - respiratory depression REFERENCE : OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 6,1207,1972 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Mammal - dog DOSE/DURATION : 157 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : NYKZAU Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. (Nippon Yakuri Gakkai, c/o Kyoto Daigaku Igakubu Yakurigaku Kyoshitsu, Konoe-cho, Yoshida, Sakyo-ku, Kyoto 606, Japan) V.40- 1944- Volume(issue)/page/year: 54,688,1958 TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Mammal - dog DOSE/DURATION : 30 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 19,1916,1969 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Mammal - cat DOSE/DURATION : 19800 ug/kg TOXIC EFFECTS : Sense Organs and Special Senses (Eye) - mydriasis (pupillary dilation) Lungs, Thorax, or Respiration - dyspnea REFERENCE : OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 6,1207,1972 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - rabbit DOSE/DURATION : 15 mg/kg TOXIC EFFECTS : Behavioral - convulsions or effect on seizure threshold Behavioral - rigidity (including catalepsy) Lungs, Thorax, or Respiration - dyspnea REFERENCE : JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 109,189,1953 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - guinea pig DOSE/DURATION : 336 mg/kg TOXIC EFFECTS : Sense Organs and Special Senses (Eye) - lacrimation REFERENCE : OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 6,1207,1972 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - guinea pig DOSE/DURATION : 150 mg/kg TOXIC EFFECTS : Sense Organs and Special Senses (Eye) - lacrimation REFERENCE : OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 6,1207,1972 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Unreported SPECIES OBSERVED : Mammal - species unspecified DOSE/DURATION : 150 mg/kg TOXIC EFFECTS : Lungs, Thorax, or Respiration - other changes REFERENCE : CPBTAL Chemical and Pharmaceutical Bulletin. (Japan Pub. Trading Co., USA, 1255 Howard St., San Francisco, CA 94103) V.6- 1958- Volume(issue)/page/year: 20,1706,1972 *** REVIEWS *** TOXICOLOGY REVIEW JRPMAP Journal of Reproductive Medicine. (2 Jacklynn Ct., St. Louis, MO 63132) V.3- 1969- Volume(issue)/page/year: 12,27,1974 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 80399 No. of Facilities: 262 (estimated) No. of Industries: 4 No. of Occupations: 9 No. of Employees: 3682 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 80399 No. of Facilities: 213 (estimated) No. of Industries: 3 No. of Occupations: 3 No. of Employees: 1826 (estimated) No. of Female Employees: 1049 (estimated)

安全

• 危险品运输编码: UN 3249
• 包装等级: III
• 危险类别: 6.1(b)
• 海关编码: 2939190090

海关

海关编码	2939190090