281678-73-7

281678-73-7结构式

常用中文名：5-溴-2,3-二氢-1-苯并呋喃-7-甲醛
常用英文名：5-BROMO-2,3-DIHYDROBENZO[B]FURAN-7-CARBALDEHYDE
CAS号：281678-73-7
分子式：C₉H₇BrO₂
分子量：227.05500
发布时间：2018-12-17 11:17:19
更新时间：2024-01-09 16:45:48

中文名	5-溴-2,3-二氢苯并[B]呋喃-7-甲醛
英文名	5-bromo-2,3-dihydro-1-benzofuran-7-carbaldehyde
英文别名	5-bromo-2,3-dihydrobenzo[b]furan-7-carboaldehyde 5-Bromo-2,3-dihydrobenzo[b]furan-7-carbaldehyde 5-Bromo-2,3-dihydrobenzofuran-7-carbaldehyde

密度	1.652g/cm3
沸点	330.1ºC at 760mmHg
分子式	C₉H₇BrO₂
分子量	227.05500
闪点	153.5ºC
精确质量	225.96300
PSA	26.30000
LogP	2.19650
蒸汽压	0.00017mmHg at 25°C
折射率	1.645
储存条件	室温

Name:	5-Bromo-2 3-dihydrobenzo[b]furan-7-carbaldehyde Material Safety Data Sheet
Synonym:	None Known
CAS:	281678-73-7

Section 1 - Chemical Product MSDS Name:5-Bromo-2 3-dihydrobenzo[b]furan-7-carbaldehyde Material Safety Data Sheet
Synonym:None Known

Section 2 - COMPOSITION, INFORMATION ON INGREDIENTS

CAS#	Chemical Name	content	EINECS#
281678-73-7	5-Bromo-2,3-dihydrobenzo[b]furan-7-car	97+	unlisted

Hazard Symbols: XI
Risk Phrases: 36/37/38 42

Section 3 - HAZARDS IDENTIFICATION

EMERGENCY OVERVIEW
Irritating to eyes, respiratory system and skin. May cause sensitization by inhalation.
Potential Health Effects
Eye:
Causes eye irritation. May cause chemical conjunctivitis.
Skin:
Causes skin irritation. May be harmful if absorbed through the skin.
Ingestion:
May cause irritation of the digestive tract. May be harmful if swallowed.
Inhalation:
Causes respiratory tract irritation. May be harmful if inhaled. May cause respiratory sensitization.
Chronic:
No information found.

Section 4 - FIRST AID MEASURES
Eyes: Immediately flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid.
Skin:
Get medical aid. Flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse.
Ingestion:
Never give anything by mouth to an unconscious person. Get medical aid. Do NOT induce vomiting. If conscious and alert, rinse mouth and drink 2-4 cupfuls of milk or water. Wash mouth out with water.
Inhalation:
Remove from exposure and move to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid.
Notes to Physician:
Treat symptomatically and supportively.

Section 5 - FIRE FIGHTING MEASURES
General Information:
As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion.
Extinguishing Media:
Use water spray, dry chemical, carbon dioxide, or chemical foam.

Section 6 - ACCIDENTAL RELEASE MEASURES
General Information: Use proper personal protective equipment as indicated in Section 8.
Spills/Leaks:
Vacuum or sweep up material and place into a suitable disposal container. Clean up spills immediately, observing precautions in the Protective Equipment section. Avoid generating dusty conditions.
Provide ventilation.

Section 7 - HANDLING and STORAGE
Handling:
Minimize dust generation and accumulation. Avoid breathing dust, vapor, mist, or gas. Avoid contact with eyes, skin, and clothing.
Keep container tightly closed. Avoid ingestion and inhalation. Use with adequate ventilation. Wash clothing before reuse.
Storage:
Store in a cool, dry place. Store in a tightly closed container.
Store under an inert atmosphere.

Section 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION
Engineering Controls:
Facilities storing or utilizing this material should be equipped with an eyewash facility and a safety shower. Use adequate ventilation to keep airborne concentrations low.
Exposure Limits CAS# 281678-73-7: Personal Protective Equipment Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166.
Skin:
Wear appropriate protective gloves to prevent skin exposure.
Clothing:
Wear appropriate protective clothing to prevent skin exposure.
Respirators:
Follow the OSHA respirator regulations found in 29 CFR 1910.134 or European Standard EN 149. Use a NIOSH/MSHA or European Standard EN 149 approved respirator if exposure limits are exceeded or if irritation or other symptoms are experienced.

Section 9 - PHYSICAL AND CHEMICAL PROPERTIES

Physical State: Solid
Color: yellow
Odor: Not available.
pH: Not available.
Vapor Pressure: Not available.
Viscosity: Not available.
Boiling Point: Not available.
Freezing/Melting Point: 93-95 deg C
Autoignition Temperature: Not available.
Flash Point: Not available.
Explosion Limits, lower: Not available.
Explosion Limits, upper: Not available.
Decomposition Temperature:
Solubility in water:
Specific Gravity/Density:
Molecular Formula: C9H7BrO2
Molecular Weight: 227.06

Section 10 - STABILITY AND REACTIVITY
Chemical Stability:
Stable at room temperature in closed containers under normal storage and handling conditions.
Conditions to Avoid:
Dust generation.
Incompatibilities with Other Materials:
Oxidizing agents, bases, amines.
Hazardous Decomposition Products:
Carbon monoxide, carbon dioxide, hydrogen bromide, bromine.
Hazardous Polymerization: Has not been reported.

Section 11 - TOXICOLOGICAL INFORMATION
RTECS#:
CAS# 281678-73-7 unlisted.
LD50/LC50:
Not available.
Carcinogenicity:
5-Bromo-2,3-dihydrobenzo[b]furan-7-carbaldehyde - Not listed by ACGIH, IARC, or NTP.

Section 12 - ECOLOGICAL INFORMATION

Section 13 - DISPOSAL CONSIDERATIONS
Dispose of in a manner consistent with federal, state, and local regulations.

Section 14 - TRANSPORT INFORMATION

IATA
Shipping Name: Not Regulated.
Hazard Class:
UN Number:
Packing Group:
IMO
Shipping Name: Not Regulated.
Hazard Class:
UN Number:
Packing Group:
RID/ADR
Shipping Name: Not Regulated.
Hazard Class:
UN Number:
Packing group:

Section 15 - REGULATORY INFORMATION

European/International Regulations
European Labeling in Accordance with EC Directives
Hazard Symbols: XI
Risk Phrases:
R 36/37/38 Irritating to eyes, respiratory system
and skin.
R 42 May cause sensitization by inhalation.
Safety Phrases:
S 22 Do not breathe dust.
S 24/25 Avoid contact with skin and eyes.
S 26 In case of contact with eyes, rinse immediately
with plenty of water and seek medical advice.
S 36/37/39 Wear suitable protective clothing, gloves
and eye/face protection.
WGK (Water Danger/Protection)
CAS# 281678-73-7: No information available.
Canada
None of the chemicals in this product are listed on the DSL/NDSL list.
CAS# 281678-73-7 is not listed on Canada's Ingredient Disclosure List.
US FEDERAL
TSCA
CAS# 281678-73-7 is not listed on the TSCA inventory.
It is for research and development use only.

SECTION 16 - ADDITIONAL INFORMATION
N/A

66826-78-6

281678-73-7

文献：Eisai Co., Ltd. Patent: EP1394147 A1, 2004 ; Location in patent: Page 92 ;

68-12-2

281678-73-7

文献：NOVO NORDISK A/S Patent: WO2006/82245 A1, 2006 ; Location in patent: Page/Page column 181-182 ;

123266-59-1

68-12-2

281678-73-7

文献：NOVO NORDISK A/S Patent: WO2006/5683 A1, 2006 ; Location in patent: Page/Page column 176-177 ;

123266-59-1

281678-73-7

文献：Hunter, Duncan H.; Janabi, Mustafa Patent: US2002/182169 A1, 2002 ;

25204-76-6

68-12-2

~35%

281678-73-7

文献：Plotkin, Michael; Chen, Sanyou; Spoors, P. Grant Tetrahedron Letters, 2000 , vol. 41, # 14 p. 2269 - 2273

118-79-6

281678-73-7

文献：Plotkin, Michael; Chen, Sanyou; Spoors, P. Grant Tetrahedron Letters, 2000 , vol. 41, # 14 p. 2269 - 2273

上游产品 5
66826-78-6 68-12-2 123266-59-1 25204-76-6
118-79-6
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