32527-55-2

• 常用中文名：噻拉米特
• 常用英文名：Tiaramide
• CAS号：32527-55-2
• 分子式：C₁₅H₁₈ClN₃O₃S
• 分子量：355.84000
• 相关类别： 原料药 抗变态反应药 过敏反应介质阻滞剂
• 发布时间：2018-02-25 08:00:00
• 更新时间：2026-07-10 06:35:24

名称

• 中文名: 噻拉米特
• 英文名: 5-chloro-3-[2-[4-(2-hydroxyethyl)piperazin-1-yl]-2-oxoethyl]-1,3-benzothiazol-2-one
• 中文别名: 5-氯-3-(2-(4-(2-羟乙基)哌嗪-1-基)-2-氧乙基)苯并[D]噻唑-2(3H)-酮; 4-[(5-氯-2-氧代-3(2H)-苯并噻唑基)乙酰基]哌嗪-1-乙醇; 氯噻哌醇
• 英文别名: USV 2592; Einecs -7; Tiamida; Tiamide; 5-Chloro-3-[[4-(2-hydroxyethyl)-1-piperazinyl]cbonylmethyl]-2,3-dihydrobenzothiazol-2-one; Rhc 2592a; 4-[(5-Chloro-2-oxo-3(2H)-benzothiazolyl)acetyl]piperazine-1-ethanol; Tiaramida [INN-Spanish]; Tiaramide [INN:BAN]; 2(3H)-Benzothiazolone, 5-chloro-3-[2-[4-(2-hydroxyethyl)-1-piperazinyl]-2-oxoethyl]; 1-[(5-chloro-2-oxo-benzothiazol-3-yl)-acetyl]-4-(2-hydroxy-ethyl)-piperazine; NTA-194; RHC 2592A; 4-[(5-Chloro-2-oxobenzothiazol-3-yl)acetyl]-1-piperazineethanol; 5-chloro-3-{2-[4-(2-hydroxyethyl)-1-piperazinyl]-2-oxoethyl}-1,3-benzothiazol-2(3H)-one; 3-[4-(2-hydroxyethyl)-1-piperazinyl]carbonylmethyl-5-chloro-2-benzothiazolinone; Tiaramidum [INN-Latin]; 5-chloro-3-[2-[4-(2-hydroxyethyl)piperazin-1-yl]-2-oxoethyl]-3H-benzothiazol-2-one; Tiamide //BP; EINECS 251-083-7; 1-Piperazineethanol, 4-((5-chloro-2-oxo-3(2H)-benzothiazolyl)acetyl)- (9ci); tialamide; 5-Chlor-2,3-dihydro-3-(4-(2-hydroxyethyl)piperazinylcbonylmethyl)-2-benzothiazolon; 35-0 (Mono-hydrochloride); 1-Piperazineethanol, 4-((5-chloro-2-oxo-3-benzothiazolinyl)acetyl); 4-((5-Chloro-2-oxo-3(2H)-benzothiazolyl)acetyl)-1-piperazineethanol; TIARAMIDE; Brn; 5-chloro-3-[4-(2-hydroxyethyl)-1-piperazinyl]carbonylmethyl-2-benzothiazolinone

物化性质

• 密度: 1.432g/cm3
• 沸点: 605.8ºC at 760mmHg
• 分子式: C₁₅H₁₈ClN₃O₃S
• 分子量: 355.84000
• 闪点: 320.2ºC
• 精确质量: 355.07600
• PSA: 94.02000
• LogP: 0.72870
• 折射率: 1.64

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : TL7047000 CHEMICAL NAME : 1-Piperazineethanol, 4-((5-chloro-2-oxo-3-benzothiazolinyl)acetyl)- CAS REGISTRY NUMBER : 32527-55-2 LAST UPDATED : 199612 DATA ITEMS CITED : 2 MOLECULAR FORMULA : C15-H18-Cl-N3-O3-S MOLECULAR WEIGHT : 355.87 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 3600 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : YKKZAJ Yakugaku Zasshi. Journal of Pharmacy. (Nippon Yakugakkai, 2-12-15 Shibuya, Shibuya-ku, Tokyo 150, Japan) No.1- 1881- Volume(issue)/page/year: 107,28,1987 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 564 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : YKKZAJ Yakugaku Zasshi. Journal of Pharmacy. (Nippon Yakugakkai, 2-12-15 Shibuya, Shibuya-ku, Tokyo 150, Japan) No.1- 1881- Volume(issue)/page/year: 107,28,1987

合成路线

103-76-4 54769-25-4 54769-22-1 ~% 32527-55-2

文献：Fujisawa Pharmaceutical Co., Ltd. Patent: US4242507 A1, 1980 ;

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