2504-32-7

• 常用中文名：O-去甲吲哚美辛
• 常用英文名：5-hydroxyindomethacin
• CAS号：2504-32-7
• 分子式：C₁₈H₁₄ClNO₄
• 分子量：343.76100
• 发布时间：2017-03-29 00:26:21
• 更新时间：2026-08-02 16:00:44

名称

• 中文名: O-去甲吲哚美辛
• 英文名: O-Desmethyl Indomethacin
• 中文别名: O-去甲基吲哚美辛
• 英文别名: 1-(4-Chlorobenzoyl)-5-hydroxy-2-methyl-1H-indole-3-acetic Acid; Indomethacin O-Desmethyl Impurity; 2-[1-(4-chlorobenzoyl)-5-hydroxy-2-methylindol-3-yl]acetic acid; 5-Hydroxy-1-(4-chlorobenzoyl)-2-methyl-1H-indole-3-acetic acid; Demethylindomethacin; Desmethylindomethacin; 1H-Indole-3-acetic acid, 1-(4-chlorobenzoyl)-5-hydroxy-2-methyl

物化性质

• 密度: 1.4g/cm3
• 沸点: 518.8ºC at 760mmHg
• 熔点: 217-219ºC
• 分子式: C₁₈H₁₄ClNO₄
• 分子量: 343.76100
• 闪点: 267.6ºC
• 精确质量: 343.06100
• PSA: 79.53000
• LogP: 3.62430
• 蒸汽压: 1.37E-11mmHg at 25°C
• 折射率: 1.651

合成路线

53-86-1 ~71% 2504-32-7

文献：NITROMED, INC. Patent: WO2006/99416 A1, 2006 ; Location in patent: Page/Page column 72 ; WO 2006/099416 A1

346424-36-0 ~89% 2504-32-7

文献：Iwata; Arisawa; Hamada; Kita; Mizutani; Tomioka; Itai; Miyamoto Journal of Medicinal Chemistry, 2001 , vol. 44, # 11 p. 1718 - 1728

2854-10-6 ~% 2504-32-7

文献：Iwata; Arisawa; Hamada; Kita; Mizutani; Tomioka; Itai; Miyamoto Journal of Medicinal Chemistry, 2001 , vol. 44, # 11 p. 1718 - 1728

52068-30-1 ~% 2504-32-7

文献：Iwata; Arisawa; Hamada; Kita; Mizutani; Tomioka; Itai; Miyamoto Journal of Medicinal Chemistry, 2001 , vol. 44, # 11 p. 1718 - 1728

346424-35-9 ~% 2504-32-7

文献：Iwata; Arisawa; Hamada; Kita; Mizutani; Tomioka; Itai; Miyamoto Journal of Medicinal Chemistry, 2001 , vol. 44, # 11 p. 1718 - 1728

上下游产品

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53-86-1 346424-36-0 2854-10-6 52068-30-1
346424-35-9
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