1874-58-4

• 常用中文名：9H-Purin-2-amine,6-[(phenylmethyl)thio]-
• 常用英文名：9H-Purin-2-amine,6-[(phenylmethyl)thio]-
• CAS号：1874-58-4
• 分子式：C₁₂H₁₁N₅S
• 分子量：257.31400
• 发布时间：2017-01-12 14:55:40
• 更新时间：2025-09-01 09:39:18

名称

• 英文名: 6-benzylsulfanyl-7H-purin-2-amine
• 英文别名: 2-Amino-6-benzylmercaptopurine; SRI 702; Benzylthioguanine; 6-Benzylthioguanine; 2-amino-6-[(phenylmethyl)thio]purine; 2-Amino-6-benzyl-MP; 6-benzylsulfanyl-7(9)H-purin-2-ylamine; Benzythioguanine; Purine,2-amino-6-(benzylthio); 6-(benzylsulfanyl)-9H-purin-2-amine; 2-amino-6-(benzyl-thio)purine; S6-benzyl-6-thioguanine; 6-[(phenylmethyl)thio]-1H-purin-2-amine

物化性质

• 密度: 1.5g/cm3
• 沸点: 441.7ºC at 760 mmHg
• 分子式: C₁₂H₁₁N₅S
• 分子量: 257.31400
• 闪点: 220.9ºC
• 精确质量: 257.07400
• PSA: 105.78000
• LogP: 2.80860
• 蒸汽压: 5.34E-08mmHg at 25°C
• 折射率: 1.789
• 储存条件: 低温通风干燥,与库房食品原料分开存放

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : UO7501000 CHEMICAL NAME : Purine, 2-amino-6-(benzylthio)- CAS REGISTRY NUMBER : 1874-58-4 LAST UPDATED : 199206 DATA ITEMS CITED : 3 MOLECULAR FORMULA : C12-H11-N5-S MOLECULAR WEIGHT : 257.34 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 222 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : NCISP* National Cancer Institute Screening Program Data Summary, Developmental Therapeutics Program. (Bethesda, MD 20205) Volume(issue)/page/year: JAN1986 ** REPRODUCTIVE DATA ** TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral DOSE : 100 mg/kg SEX/DURATION : female 7 day(s) after conception TOXIC EFFECTS : Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) REFERENCE : JRPFA4 Journal of Reproduction and Fertility. (Biochemical Soc. Book Depot, POB 32, Commerce Way, Colchester, Essex CO2 8HP, UK) V.1- 1960- Volume(issue)/page/year: 4,291,1962 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intraperitoneal DOSE : 50 mg/kg SEX/DURATION : female 7 day(s) after conception TOXIC EFFECTS : Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) REFERENCE : JRPFA4 Journal of Reproduction and Fertility. (Biochemical Soc. Book Depot, POB 32, Commerce Way, Colchester, Essex CO2 8HP, UK) V.1- 1960- Volume(issue)/page/year: 4,291,1962

合成路线

99864-74-1 ~% 1874-58-4

文献：Gibson, Colin L.; La Rosa, Salvatore; Suckling, Colin J. Organic and Biomolecular Chemistry, 2003 , vol. 1, # 11 p. 1909 - 1918

100-53-8 ~% 1874-58-4

文献：Gibson, Colin L.; La Rosa, Salvatore; Suckling, Colin J. Organic and Biomolecular Chemistry, 2003 , vol. 1, # 11 p. 1909 - 1918

606964-86-7 ~% 1874-58-4

文献：Gibson, Colin L.; La Rosa, Salvatore; Suckling, Colin J. Organic and Biomolecular Chemistry, 2003 , vol. 1, # 11 p. 1909 - 1918

84097-36-9 ~% 1874-58-4

文献：Gibson, Colin L.; La Rosa, Salvatore; Suckling, Colin J. Organic and Biomolecular Chemistry, 2003 , vol. 1, # 11 p. 1909 - 1918

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