158585-86-5

• 常用中文名：6,8-二氟-1-(甲酰基甲基氨基)-7-(4-甲基-1-哌嗪基)-4-氧代-1,4-二氢喹啉-3-甲酸乙酯
• 常用英文名：6,8-Difluoro-1-(formylmethylamino)-1,4-dihydro-7-(4-methyl-1-piperazinyl)-4-oxo-3-quinolinecarboxylic acid ethyl ester
• CAS号：158585-86-5
• 分子式：C₁₉H₂₂F₂N₄O₄
• 分子量：408.39900
• 发布时间：2018-12-29 02:51:09
• 更新时间：2024-02-02 19:01:52

名称

• 中文名: 6,8-二氟-1-(甲酰基甲基氨基)-7-(4-甲基-1-哌嗪基)-4-氧代-1,4-二氢喹啉-3-甲酸乙酯
• 英文名: ethyl 6,8-difluoro-7-(4-methylpiperazin-1-yl)-4-oxo-1-(2-oxoethylamino)quinoline-3-carboxylate
• 中文别名: 6,8-二氟-1-(甲酰基甲基氨基)-7-(4-甲基哌嗪-1-基)-4-氧代-1,4-二氢喹啉-3-羧酸乙酯
• 英文别名: 3-Quinolinecarboxylicacid,6,8-difluoro-1-(formylmethylamino)-1,4-dihydro-7-(4-methyl-1-piperazinyl)-4-oxo-,ethyl ester; Ethyl6,8-difluoro-1,4-dihydro-1-(N-methylformamido)-7-(4-methyl-1-piperazinyl)-4-oxo-3-quinolinecarboxylate; 6,8-difluoro-1-(N-methylformamido)-7-(4-methylpiperazin-1-yl)-4-oxo-1,4-quinoline-3-carboxylic acid ethyl ester; I06-2622; 6,8-DIFLUORO-1-(FORMYLMETHYLAMINO)-7-(4-METHYLPIPERAZIN-1-YL)-4-OXO-1,4-DIHYDROQUINOLINE-3-CARBOXYLIC ACID ETHYL ESTER; ethyl 6,8-difluoro-1-(N-methylformamido)-7-(4-methylpiperazin-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylate

物化性质

• 密度: 1.41
• 沸点: 543.7ºC at 760 mmHg
• 分子式: C₁₉H₂₂F₂N₄O₄
• 分子量: 408.39900
• 精确质量: 408.16100
• PSA: 83.88000
• LogP: 1.02650
• 折射率: 1.612
• 储存条件: 室温

合成路线

103994-82-7 758-17-8 ~% 158585-86-5

文献：US5892040 A1, ;

109-01-3 100276-65-1 ~58% 158585-86-5

文献：KRKA, TOVARNA ZDRAVIL, D.D., NOVO MESTO; ZUPET, Rok; ISKRA, Jernej; RUZIC, Milos; PECAVAR, Anica; KOLENC, Ivanka; PUCELJ, Joze; PLAPER, Igor Patent: WO2011/61292 A1, 2011 ; Location in patent: Page/Page column 43-44 ;

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