329216-67-3

• 常用中文名：2-(4-(二苯并[b,f][1,4]硫氮杂卓-11-基)哌嗪-1-基)乙醇
• 常用英文名：4-Dibenzo[b,f][1,4]thiazepin-11-yl-1-piperazineethanol
• CAS号：329216-67-3
• 分子式：C₁₉H₂₁N₃OS
• 分子量：339.454
• 发布时间：2018-03-22 08:00:00
• 更新时间：2025-09-11 11:49:06

名称

• 中文名: 4-二苯并[b,f][1,4]硫氮杂卓-11-基-1-哌嗪乙醇
• 英文名: 2-(4-benzo[b][1,4]benzothiazepin-6-ylpiperazin-1-yl)ethanol
• 中文别名: 喹硫平杂质2(喹硫平杂质I); 喹硫平杂质2; 2-(4-苯并[B][1,4]苯并硫杂-6-基哌嗪-1-基)乙醇; 喹硫平杂质1; 2-(4-(二苯并[B,F][1,4]硫氮杂卓-11-基)哌嗪-1-基)乙醇; 富马酸喹硫平杂质I; 富马酸喹硫平杂质 I; 喹硫平杂质I; 喹硫平杂质I对照品; 富马酸喹硫平中间体6; Α-缩宫素二聚体; 喹硫平杂质I(喹硫平羟基杂质); 喹硫平去羟乙基杂质; 杂质I; 奎硫平杂质I; (2-羟乙基)哌嗪-1-基二硫氮; 奎硫平去羟乙基杂质
• 英文别名: 2-(4-Dibenzo[b,f][1,4]thiazin-11-yl-piperazin-1-yl)-ethanol; Desethoxy QuetiapineQ: What is Desethoxy Quetiapine Q: What is the CAS Number of Desethoxy Quetiapine Q: What is the storage condition of Desethoxy Quetiapine Q: What e the applications of Desethoxy Quetiapine; quetiapine impurity I; Quetiapine Impurity I/Quetiapine Hydroxy Impurit; Pallel dimer; Quetiapine fumate Imp. I : -(dibenzob,f1,4thiazin-11-yl)piperazin-1-ylethanol; T C676 BS INJ C- AT6N DNTJ D2Q; Quintiapine impurity I; 2-[4-(Dibenzo[b,f][1,4]thiazepin-11-yl)-1-piperazinyl]ethanol; Quetiapine IMpurity I (Quetiapine Hydroxy IMpurity); Quetiapine Hydroxy Impurity Dihydrochloride Salt; 2-(4-benzo[b][1,4]benzothiazin-6-ylpiperazin-1-yl)ethanol; 2-(4-(dibenzo[b,f][1,4]thiazin-11-yl)piperazin-1-yl)ethanoldihydrochloride; 1-Piperazineethanol, 4-dibenzo[b,f][1,4]thiazin-11-yl; Quetiapine Impurity I (base)); QUETIAPINE DESETHOXY; 2-[4-(Dibenzo[b,f][1,4]thiazepin-11-yl)piperazin-1-yl]ethanol; Quetiapine Impurity 2(Quetiapine Impurity I); O-Dealkyl Quetiapine; QUETIAPINE DESETHOXY (1A00190); 4-Dibenzo[b,f][1,4]thiazin-11-yl-1-piperazineethanol; Quetiapine Impurity I Control; Quetiapine impurity 1; 2-[4-(dibenzo[b,f][1,4]thiazin-11-yl)piperazin-1-yl]ethanol(Quetiapine Impurity I); Quetiapine Impurity 2; 11-(4-[2-HYDROXYETHYL]PIPERAZIN-1-YL)DIBENZO[B,F][1,4]THIAZINE; 11-[4-(2-Hydroxyethyl)-1-Piperazinyl]-Dibenzo[D, F][1,4]Thiazine; 4-Dibenzo[β,f][1,4]thiazin-11-yl-1-piperazineethanol; Quetiapine Deshydroxyethyl IMpurity; Quetiapine Hydroxy Impurity

物化性质

• 密度: 1.3±0.1 g/cm3
• 沸点: 523.4±60.0 °C at 760 mmHg
• 分子式: C₁₉H₂₁N₃OS
• 分子量: 339.454
• 闪点: 270.3±32.9 °C
• 精确质量: 339.140533
• PSA: 64.37000
• LogP: 2.27
• 蒸汽压: 0.0±1.4 mmHg at 25°C
• 折射率: 1.683
• 储存条件: 2-8°C

合成路线

103-76-4 13745-86-3 ~51% 329216-67-3

文献：CONCERT PHARMACEUTICALS INC. Patent: WO2008/66620 A2, 2008 ; Location in patent: Page/Page column 23-24 ;

5747-48-8 540-51-2 ~83% 329216-67-3

文献：AUSPEX PHARMACEUTICALS, INC. Patent: US2010/69356 A1, 2010 ; Location in patent: Page/Page column 26-27 ; US 20100069356 A1

103-76-4 546-68-9 3159-07-7 ~92% 329216-67-3 详细

文献：UNION QUIMICO-FARMACEUTICA S.A. Patent: WO2006/94549 A1, 2006 ; Location in patent: Page/Page column 17-18 ;

3159-07-7 ~% 329216-67-3

文献：Warawa; Migler; Ohnmacht; Needles; Gatos; McLaren; Nelson; Kirkland Journal of Medicinal Chemistry, 2001 , vol. 44, # 3 p. 372 - 389

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