376591-95-6

• 常用中文名：2-羟基-3'-硝基-联苯-3-甲酸
• 常用英文名：2'-Hydroxy-3'-nitro-[1,1'-biphenyl]-3-carboxylic acid
• CAS号：376591-95-6
• 分子式：C₁₃H₉NO₅
• 分子量：259.214
• 发布时间：2018-12-18 20:32:21
• 更新时间：2026-07-01 16:19:18

名称

• 中文名: 2-羟基-3-硝基-联苯-3-羧酸
• 英文名: 2-Hydroxy-3-nitrobiphenyl-3-carboxylic acid
• 中文别名: 2‘-羟基-3'-硝基-联苯-3-甲酸 (CAS; 艾曲泊帕乙醇胺SM2-Imp5; 2'-羟基-3'-硝基-3-联苯基羧酸; 艾曲波帕中间体; 艾曲泊帕中间体2对照品; 艾曲波帕(Eltrombopag)中间体2; 3'-硝基-2'-羟基联苯-3-羧酸; 2-羟基-硝基-3-联苯基羧酸; 2'-羟基-3'-硝基-[1,1'-联苯]-3-羧酸; 2'-羟基-3'-硝基-联苯-3-羧酸; 2'-羟基-3'-硝基-3-联苯基羧酸(艾曲波帕中间体); 2'-羟基-3'-硝基联苯-3-羧酸; 艾曲泊帕杂质44; 艾曲波帕杂质13; 艾曲波帕杂质21; 艾曲波帕杂质44; 艾曲泊帕杂质51
• 英文别名: [1,1'-Biphenyl]-3-cboxylic acid, 2'-hydroxy-3'-nitro; 3’-Nitro-2’-hydroxy[1,1’]-biphenyl-3-cboxylic Acid; 2'- hydroxy -3'- nitrobiphenyl -3- cboxylic acid; [1,1'-Biphenyl]-3-carboxylic acid,2'-hydroxy-3'-nitro; Eltrombopag Impurity 44; Eltrombopag Impurity 21; Eltrombopag Impurity 13; 4,5,9,16-Pyrenetetrone; Eltrombopag olamine Intermediate 2; 3-(2-hydroxy-3-nitrophenyl)benzoic acid; 3-(2-hydroxy-3-nitrophenyl)benzoicaci; 2'-hydroxy-3'-nitro-3-biphenylcboxylic acid; 2'-Hydroxy-3'-nitrobiphenyl-3-carboxylic acid; 2'-Hydroxy-3'-nitro-3-biphenylcarboxylic acid; 2'-Hydroxy-3'-nitro-[1,1'-biphenyl]-3-cboxylic acid; Eltrombopag o; 2'-hydroxy-3'-nitro-3- biphenylcboxylic acid; 2-HYDROXY-3''-NITRO-BIPHENYL-3-CBOXYLIC ACID; Nalbuphine Impurity 11

物化性质

• 密度: 1.5±0.1 g/cm3
• 沸点: 452.2±40.0 °C at 760 mmHg
• 分子式: C₁₃H₉NO₅
• 分子量: 259.214
• 闪点: 193.8±15.8 °C
• 精确质量: 259.048065
• PSA: 103.35000
• LogP: 2.83
• 蒸汽压: 0.0±1.2 mmHg at 25°C
• 折射率: 1.669
• 储存条件: 室温

合成路线

893736-72-6 ~% 376591-95-6

文献：LIGAND PHARMACEUTICALS, INC. Patent: WO2006/47344 A1, 2006 ; Location in patent: Page/Page column 45; 155 ;

376591-94-5 ~76% 376591-95-6

文献：Erickson-Miller, Connie J; Eppley, Daniel F.; Jenkins, Julian; Luengo, Juan I.; Liu, Nannan; Price, Alan T.; Shaw, Anthony N.; Visonneau, Sophie; Wiggall, Kenneth Patent: US2004/19190 A1, 2004 ; Location in patent: Page 18 ;

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