CHEMICAL IDENTIFICATION
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RTECS NUMBER :
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DU9100000
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CHEMICAL NAME :
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4-Biphenylamine, 3,2'-dimethyl-
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CAS REGISTRY NUMBER :
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13394-86-0
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BEILSTEIN REFERENCE NO. :
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2936819
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LAST UPDATED :
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199612
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DATA ITEMS CITED :
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32
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MOLECULAR FORMULA :
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C14-H15-N
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MOLECULAR WEIGHT :
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197.30
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WISWESSER LINE NOTATION :
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ZR B1 DR B1
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
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TYPE OF TEST :
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LD50 - Lethal dose, 50 percent kill
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ROUTE OF EXPOSURE :
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Intraperitoneal
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SPECIES OBSERVED :
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Rodent - mouse
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DOSE/DURATION :
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1130 mg/kg
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TOXIC EFFECTS :
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Details of toxic effects not reported other than lethal dose value
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TYPE OF TEST :
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TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Subcutaneous
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SPECIES OBSERVED :
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Rodent - rat
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DOSE/DURATION :
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800 mg/kg/4W-I
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TOXIC EFFECTS :
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Tumorigenic - Carcinogenic by RTECS criteria Reproductive - Tumorigenic effects - prostate tumors
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TYPE OF TEST :
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TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Subcutaneous
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SPECIES OBSERVED :
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Rodent - rat
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DOSE/DURATION :
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501 mg/kg/I
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TOXIC EFFECTS :
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Tumorigenic - Carcinogenic by RTECS criteria Gastrointestinal - tumors
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TYPE OF TEST :
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TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Parenteral
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SPECIES OBSERVED :
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Rodent - rat
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DOSE/DURATION :
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280 mg/kg/14W-I
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TOXIC EFFECTS :
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Tumorigenic - equivocal tumorigenic agent by RTECS criteria Gastrointestinal - colon tumors Liver - tumors
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TYPE OF TEST :
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TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Subcutaneous
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SPECIES OBSERVED :
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Rodent - hamster
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DOSE/DURATION :
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2300 mg/kg/37W-I
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TOXIC EFFECTS :
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Tumorigenic - Carcinogenic by RTECS criteria Kidney, Ureter, Bladder - tumors Reproductive - Tumorigenic effects - ovarian tumors
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TYPE OF TEST :
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TD - Toxic dose (other than lowest)
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ROUTE OF EXPOSURE :
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Subcutaneous
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SPECIES OBSERVED :
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Rodent - hamster
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DOSE/DURATION :
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1095 mg/kg/37W-I
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TOXIC EFFECTS :
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Tumorigenic - Carcinogenic by RTECS criteria Kidney, Ureter, Bladder - tumors Liver - tumors
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TYPE OF TEST :
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TD - Toxic dose (other than lowest)
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ROUTE OF EXPOSURE :
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Subcutaneous
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SPECIES OBSERVED :
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Rodent - rat
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DOSE/DURATION :
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960 mg/kg/21W-I
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TOXIC EFFECTS :
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Tumorigenic - Carcinogenic by RTECS criteria Gastrointestinal - tumors Gastrointestinal - colon tumors
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TYPE OF TEST :
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TD - Toxic dose (other than lowest)
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ROUTE OF EXPOSURE :
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Subcutaneous
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SPECIES OBSERVED :
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Rodent - rat
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DOSE/DURATION :
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1000 mg/kg/20W-I
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TOXIC EFFECTS :
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Tumorigenic - Carcinogenic by RTECS criteria Sense Organs and Special Senses (Ear) - effect, not otherwise specified Gastrointestinal - tumors
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TYPE OF TEST :
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TD - Toxic dose (other than lowest)
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ROUTE OF EXPOSURE :
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Subcutaneous
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SPECIES OBSERVED :
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Rodent - hamster
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DOSE/DURATION :
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4440 mg/kg/77W-I
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TOXIC EFFECTS :
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Tumorigenic - Carcinogenic by RTECS criteria Gastrointestinal - tumors Kidney, Ureter, Bladder - tumors
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TYPE OF TEST :
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TD - Toxic dose (other than lowest)
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ROUTE OF EXPOSURE :
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Subcutaneous
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SPECIES OBSERVED :
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Rodent - rat
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DOSE/DURATION :
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1000 mg/kg/20W-I
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TOXIC EFFECTS :
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Tumorigenic - Carcinogenic by RTECS criteria Gastrointestinal - tumors Gastrointestinal - colon tumors
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TYPE OF TEST :
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TD - Toxic dose (other than lowest)
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ROUTE OF EXPOSURE :
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Subcutaneous
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SPECIES OBSERVED :
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Rodent - rat
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DOSE/DURATION :
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10400 mg/kg/2Y-I
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TOXIC EFFECTS :
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Tumorigenic - Carcinogenic by RTECS criteria Gastrointestinal - colon tumors
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TYPE OF TEST :
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TD - Toxic dose (other than lowest)
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ROUTE OF EXPOSURE :
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Subcutaneous
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SPECIES OBSERVED :
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Rodent - hamster
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DOSE/DURATION :
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2 gm/kg/20W-I
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TOXIC EFFECTS :
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Tumorigenic - neoplastic by RTECS criteria Kidney, Ureter, Bladder - tumors
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TYPE OF TEST :
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TD - Toxic dose (other than lowest)
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ROUTE OF EXPOSURE :
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Subcutaneous
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SPECIES OBSERVED :
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Rodent - rat
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DOSE/DURATION :
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1400 mg/kg/14W-I
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TOXIC EFFECTS :
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Tumorigenic - Carcinogenic by RTECS criteria Gastrointestinal - colon tumors Skin and Appendages - tumors
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TYPE OF TEST :
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TD - Toxic dose (other than lowest)
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ROUTE OF EXPOSURE :
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Subcutaneous
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SPECIES OBSERVED :
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Rodent - rat
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DOSE/DURATION :
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2300 mg/kg/36W-I
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TOXIC EFFECTS :
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Tumorigenic - Carcinogenic by RTECS criteria Kidney, Ureter, Bladder - inflammation, necrosis, or scarring of bladder Kidney, Ureter, Bladder - tumors
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TYPE OF TEST :
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TD - Toxic dose (other than lowest)
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ROUTE OF EXPOSURE :
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Subcutaneous
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SPECIES OBSERVED :
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Rodent - rat
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DOSE/DURATION :
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1100 mg/kg/31W-I
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TOXIC EFFECTS :
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Tumorigenic - Carcinogenic by RTECS criteria Gastrointestinal - tumors Gastrointestinal - colon tumors
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TYPE OF TEST :
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DNA adduct
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TYPE OF TEST :
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Unscheduled DNA synthesis
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TYPE OF TEST :
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Cytogenetic analysis
MUTATION DATA
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TYPE OF TEST :
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Morphological transformation
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TEST SYSTEM :
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Rodent - hamster Embryo
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DOSE/DURATION :
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100 ug/L
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REFERENCE :
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NCIMAV National Cancer Institute, Monograph. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) No.1- 1959- Volume(issue)/page/year: 58,243,1981 *** REVIEWS *** TOXICOLOGY REVIEW ADCSAJ Advances in Chemistry Series. (American Chemical Soc., Distribution Office Dept. 223, POB 57136, West End Stn., Washington, DC 20037) No.1- 1950- Volume(issue)/page/year: 13,271,1970 TOXICOLOGY REVIEW JJIND8 JNCI, Journal of the National Cancer Institute. (Washington, DC) V.61-79, 1978-87. For publisher information, see JNCIEQ. Volume(issue)/page/year: 68,867,1982
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