品牌现货直购
供应商:我要出现这里







查看所有供应商和价格请点击:

76144-81-5生产厂家

76144-81-5价格

76144-81-5

76144-81-5结构式
76144-81-5结构式
  • 常用中文名:米屈肼
  • 常用英文名:Mildronate
  • CAS号:76144-81-5
  • 分子式:C6H14N2O2
  • 分子量:146.188
  • 相关类别: 原料药 循环系统用药 抗充血性心力衰竭药
  • 发布时间:2018-03-29 08:00:00
  • 更新时间:2024-01-02 19:47:13
  • Mildronate (Meldonium) 是一种心血管保护药,可竞争性的抑制 BBOX1 和OCTN2。Mildronate (Meldonium) 对人重组 BBOX 的 IC50 值为 34-62 μM,对人OCTN2 的 EC50 值为 21 μM。Mildronate (Meldonium) 可诱导长链脂肪酸代谢从线粒体向过氧化物酶体的重定向。

化源商城直购

中文名 米屈肼二水合物
英文名 Mildronate dihydrate
中文别名 美度铵
米屈肼
英文别名 Diazanium, 2-(2-carboxyethyl)-1,1,1-trimethyl-, inner salt
MET88
Meldonium
3-(2,2,2-Trimethyldiazan-2-ium-1-yl)propanoate
MFCD00876389
Quaterin
Mildronate
UNII-73H7UDN6EC
描述 Mildronate (Meldonium) 是一种心血管保护药,可竞争性的抑制 BBOX1 和OCTN2。Mildronate (Meldonium) 对人重组 BBOX 的 IC50 值为 34-62 μM,对人OCTN2 的 EC50 值为 21 μM。Mildronate (Meldonium) 可诱导长链脂肪酸代谢从线粒体向过氧化物酶体的重定向。
相关类别
靶点

IC50: 34-62 μM (human recombinant BBOX). EC50: 21 μM (human OCTN2).

参考文献

[1]. Dambrova M, et al. Pharmacological effects of meldonium: Biochemical mechanisms and biomarkers of cardiometabolic activity. Pharmacol Res. 2016 Nov;113(Pt B):771-780.

[2]. Schobersberger W, et al. Story behind meldonium-from pharmacology to performance enhancement: a narrative review. Br J Sports Med. 2017 Jan;51(1):22-25.

熔点 85-90ºC
分子式 C6H14N2O2
分子量 146.188
精确质量 146.105530
PSA 52.16000
外观性状 白色结晶粉末
折射率 1.598
储存条件 Refrigerator
稳定性 Hygroscopic

CHEMICAL IDENTIFICATION

RTECS NUMBER :
MW0333620
CHEMICAL NAME :
Hydrazinium, 2-(2-carboxyethyl)-1,1,1-trimethyl-, hydroxide, inner salt
CAS REGISTRY NUMBER :
76144-81-5
LAST UPDATED :
199703
DATA ITEMS CITED :
7
MOLECULAR FORMULA :
C6-H14-N2-O2
MOLECULAR WEIGHT :
146.22

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
>20 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
EKFMA7 Eksperimental'naya i Klinicheskaya Farmakoterapiya. (Izdatel'stvo Zinantne, Riga, USSR) No.1- 1970- Volume(issue)/page/year: 19,67,1991
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
12 gm/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Lungs, Thorax, or Respiration - respiratory stimulation
REFERENCE :
EKFMA7 Eksperimental'naya i Klinicheskaya Farmakoterapiya. (Izdatel'stvo Zinantne, Riga, USSR) No.1- 1970- Volume(issue)/page/year: 19,67,1991
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
18500 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
EKFMA7 Eksperimental'naya i Klinicheskaya Farmakoterapiya. (Izdatel'stvo Zinantne, Riga, USSR) No.1- 1970- Volume(issue)/page/year: 19,67,1991
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
7850 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
BAXXDU British UK Patent Application. (U.S. Patent and Trademark Office, Foreign Patents, Washington, DC 20231) Volume(issue)/page/year: #2105992
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
4430 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
BAXXDU British UK Patent Application. (U.S. Patent and Trademark Office, Foreign Patents, Washington, DC 20231) Volume(issue)/page/year: #2105992
TYPE OF TEST :
LD - Lethal dose
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Mammal - cat
DOSE/DURATION :
>4 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
EKFMA7 Eksperimental'naya i Klinicheskaya Farmakoterapiya. (Izdatel'stvo Zinantne, Riga, USSR) No.1- 1970- Volume(issue)/page/year: 19,67,1991
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
8 gm/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Lungs, Thorax, or Respiration - respiratory depression Lungs, Thorax, or Respiration - other changes
REFERENCE :
EKFMA7 Eksperimental'naya i Klinicheskaya Farmakoterapiya. (Izdatel'stvo Zinantne, Riga, USSR) No.1- 1970- Volume(issue)/page/year: 19,67,1991

海关编码 2928000090
上游产品  2

下游产品  0

海关编码 2928000090
中文概述 2928000090 其他肼(联氨)及胲(羟胺)的有机衍生物。监管条件:无。增值税率:17.0%。退税率:9.0%。最惠国关税:6.5%。普通关税:20.0%
申报要素 品名, 成分含量, 用途
Summary 2928000090 other organic derivatives of hydrazine or of hydroxylamine VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:20.0%