82230-53-3

• 常用中文名：吉立索泮
• 常用英文名：GYKI 51189
• CAS号：82230-53-3
• 分子式：C₁₈H₁₇ClN₂O₂
• 分子量：328.79300
• 发布时间：2018-04-03 08:00:00
• 更新时间：2024-01-05 22:21:29

名称

• 中文名: 吉立索泮
• 英文名: 1-(3-chlorophenyl)-7,8-dimethoxy-4-methyl-5H-2,3-benzodiazepine
• 英文别名: Girisopam [INN]; 1-(3-Chlorophenyl)-4-methyl-7,8-dimethoxy-5H-2,3-benzodiazepine; Girisopamum [INN-Latin]; 1-(3-Chlorphenyl)-7,8-dimethoxy-4-methyl-5H-2,3-benzodiazepin; 1-(m-Chlorophenyl)-7,8-dimethoxy-4-methyl-5H-2,3-benzodiazepine; [3H]-Girisopam; 5H-2,3-Benzodiazepine,1-(3-chlorophenyl)-7,8-dimethoxy-4-methyl; Girisopam

物化性质

• 密度: 1.23g/cm3
• 沸点: 453.9ºC at 760 mmHg
• 分子式: C₁₈H₁₇ClN₂O₂
• 分子量: 328.79300
• 闪点: 228.3ºC
• 精确质量: 328.09800
• PSA: 43.18000
• LogP: 2.99780
• 折射率: 1.598

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : DE9480200 CHEMICAL NAME : 5H-2,3-Benzodiazepine, 1-(3-chlorophenyl)-7,8-dimethoxy-4-methyl- CAS REGISTRY NUMBER : 82230-53-3 LAST UPDATED : 199612 DATA ITEMS CITED : 4 MOLECULAR FORMULA : C18-H17-Cl-N2-O2 MOLECULAR WEIGHT : 328.82 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : >2 gm/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 37,1119,1987 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 670 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 37,1119,1987 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 1250 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 37,1119,1987 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 330 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 37,1119,1987

合成路线

93-40-3 ~% 82230-53-3

文献：Bihel, Frederic J.J.; Justiniano, Helene; Schmitt, Martine; Hellal, Malik; Ibrahim, Mohamed A.; Lugnier, Claire; Bourguignon, Jean-Jacques Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 21 p. 6567 - 6572

474055-25-9 ~% 82230-53-3

文献：Bihel, Frederic J.J.; Justiniano, Helene; Schmitt, Martine; Hellal, Malik; Ibrahim, Mohamed A.; Lugnier, Claire; Bourguignon, Jean-Jacques Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 21 p. 6567 - 6572

15964-79-1 ~% 82230-53-3

文献：Bihel, Frederic J.J.; Justiniano, Helene; Schmitt, Martine; Hellal, Malik; Ibrahim, Mohamed A.; Lugnier, Claire; Bourguignon, Jean-Jacques Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 21 p. 6567 - 6572

474070-11-6 917-54-4 ~% 82230-53-3

文献：Bihel, Frederic J.J.; Justiniano, Helene; Schmitt, Martine; Hellal, Malik; Ibrahim, Mohamed A.; Lugnier, Claire; Bourguignon, Jean-Jacques Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 21 p. 6567 - 6572

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