439239-92-6

• 常用中文名：琥珀酸拉米丹
• 常用英文名：Lasmiditan hemisuccinate
• CAS号：439239-92-6
• 分子式：C₄₂H₄₂F₆N₆O₈
• 分子量：872.80900
• 发布时间：2018-06-13 14:41:51
• 更新时间：2024-01-14 10:18:21
• Lasmiditan, also known as COL-144 and LY573144, is a novel, centrally acting, highly selective 5-HT(1F) receptor agonist (K1=2.21 μM) without vasoconstrictor activity that seemed effective when given as an intravenous infusion in a proof-of-concept migraine study. Lasmiditan showed efficacy in its primary endpoint, with a 2-hour placebo-subtracted headache response of 28.8%, though with frequent reports of dizziness, paresthesias, and vertigo.

名称

• 中文名: 琥珀酸拉米丹
• 英文名: butanedioic acid,2,4,6-trifluoro-N-[6-(1-methylpiperidine-4-carbonyl)pyridin-2-yl]benzamide
• 英文别名: Lasmiditan succinate (USAN); 2,4,6-Trifluoro-N-(6-((1-methylpiperidine-4-yl)carbonyl)pyridin-2-yl)benzamide hemisuccinate; UNII-W64YBJ346B; Lasmiditan succinate; Lasmiditan hemisuccinate

物化性质

• 分子式: C₄₂H₄₂F₆N₆O₈
• 分子量: 872.80900
• 精确质量: 872.29700
• PSA: 206.18000
• LogP: 7.13100
• 储存条件: -20°C， 密封， 干燥