5432-28-0

• 常用中文名：N-环己基-N-甲基亚硝胺
• 常用英文名：Cyclohexanamine,N-methyl-N-nitroso
• CAS号：5432-28-0
• 分子式：C₇H₁₄N₂O
• 分子量：142.19900
• 发布时间：2017-01-18 16:44:06
• 更新时间：2026-07-14 17:30:13

名称

• 中文名: N-环己基-N-甲基亚硝胺
• 英文名: N-cyclohexyl-N-methylnitrous amide
• 中文别名: 卡利拉嗪杂质16; 溴己新杂质07; 卡利拉嗪杂质29; 溴己新杂质96; N-亚硝基布朗己新杂质 6; 溴己新杂质32; N-亚硝基溴己新杂质; 卡利拉嗪杂质29 (N-甲基-N-亚硝基环己胺); (环己基)甲基亚硝胺
• 英文别名: N-Nitroso-N-cyclohexylmethylamine; METHYLCYCLOHEXYLNITROSAMINE; Cyclohexyl-methyl-nitroso-amin; N-nitroso-N-methylcyclohexylamine; Bromhexine Impurity 96; N-Nitroso Bromhexine Impurity; Cyclohexylmethylnitrosamine; Cyclohexylamine,N-nitroso-N-methyl; N-Nitrosomethylcyclohexylamine; N-Methyl-N-nitrosocyclohexylamine; N-NITROSOMETHYLCYCLOHEXYLAMINE; N-Nitroso Bromhexine Impurity 6; Cyclohexanamine, N-methyl-N-nitroso; (Cyclohexyl)methylnitrosamine; CYCLOHEXYLAMINE,N-METHYL-N-NITROSO; N-nitroso-bromohexine impurity; Ciprazine Impurity 29 (N-methyl-N-nitrosocyclohexanamine); Caliprazine impurity 16; Methylcyclohexylnitrosamine; N-Cylohexyl-N-Methyl nitrous amide; Methylcyclohexylnitrosamin; cyclohexyl-methyl-nitroso-amine

物化性质

• 密度: 1.1g/cm3
• 沸点: 256.8ºC at 760 mmHg
• 分子式: C₇H₁₄N₂O
• 分子量: 142.19900
• 闪点: 109.1ºC
• 精确质量: 142.11100
• PSA: 32.67000
• LogP: 1.93230
• 折射率: 1.534

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : GX1575000 CHEMICAL NAME : Cyclohexylamine, N-methyl-N-nitroso- CAS REGISTRY NUMBER : 5432-28-0 BEILSTEIN REFERENCE NO. : 1841408 LAST UPDATED : 199612 DATA ITEMS CITED : 11 MOLECULAR FORMULA : C7-H14-N2-O MOLECULAR WEIGHT : 142.23 WISWESSER LINE NOTATION : L6TJ AN1&NO HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 30 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 28 mg/kg TOXIC EFFECTS : Behavioral - convulsions or effect on seizure threshold Gastrointestinal - changes in structure or function of salivary glands Skin and Appendages - hair TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 30 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 57 mg/kg TOXIC EFFECTS : Behavioral - convulsions or effect on seizure threshold Gastrointestinal - changes in structure or function of salivary glands Skin and Appendages - hair TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - hamster DOSE/DURATION : 168 mg/kg TOXIC EFFECTS : Behavioral - convulsions or effect on seizure threshold Gastrointestinal - changes in structure or function of salivary glands Skin and Appendages - hair TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 150 mg/kg/54W-C TOXIC EFFECTS : Tumorigenic - equivocal tumorigenic agent by RTECS criteria Gastrointestinal - tumors TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - hamster DOSE/DURATION : 1024 mg/kg/50W-I TOXIC EFFECTS : Tumorigenic - equivocal tumorigenic agent by RTECS criteria Liver - tumors Lungs, Thorax, or Respiration - tumors TYPE OF TEST : TD - Toxic dose (other than lowest) ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 190 mg/kg/45W-C TOXIC EFFECTS : Tumorigenic - equivocal tumorigenic agent by RTECS criteria Lungs, Thorax, or Respiration - tumors Gastrointestinal - tumors TYPE OF TEST : TD - Toxic dose (other than lowest) ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 750 mg/kg/45W-C TOXIC EFFECTS : Tumorigenic - equivocal tumorigenic agent by RTECS criteria Gastrointestinal - tumors Blood - lymphoma, including Hodgkin's disease MUTATION DATA TYPE OF TEST : Phage inhibition capacity TEST SYSTEM : Bacteria - Escherichia coli DOSE/DURATION : 100 mg/L REFERENCE : TCMUE9 Topics in Chemical Mutagenesis. (Plenum Pub. Corp., 233 Spring Street, New York, NY 10013) V.1- 1984- Volume(issue)/page/year: 1,91,1984

安全

• 海关编码: 2928000090

合成路线

100-60-7 ~99% 5432-28-0

文献：Zolfigol, Mohammad Ali; Choghamarani, Arash Ghorbani; Hazarkhani, Hassan Synlett, 2002 , # 6 p. 1002 - 1004

98-94-2 ~% 5432-28-0

文献：Skita; Rolfes Chemische Berichte, 1920 , vol. 53, p. 1255

611-75-6 ~% 5432-28-0

文献：Farmer; Parry; Franke; Schmid Arzneimittel-Forschung/Drug Research, 1988 , vol. 38, # 9 p. 1351 - 1354

60-29-7 98-94-2 ~% 5432-28-0

文献：Skita; Rolfes Chemische Berichte, 1920 , vol. 53, p. 1255

上下游产品

上游产品  4
100-60-7 98-94-2 611-75-6 60-29-7
下游产品  2
100-60-7 33668-52-9

海关

海关编码	2928000090
中文概述	2928000090 其他肼（联氨）及胲（羟胺）的有机衍生物。监管条件:无。增值税率:17.0%。退税率:9.0%。最惠国关税:6.5%。普通关税:20.0%
申报要素	品名, 成分含量, 用途
Summary	2928000090 other organic derivatives of hydrazine or of hydroxylamine VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:20.0%