914-00-1

• 常用中文名：甲烯土霉素
• 常用英文名：methacycline
• CAS号：914-00-1
• 分子式：C₂₂H₂₂N₂O₈
• 分子量：442.41900
• 相关类别： 原料药 抗生素类药物 四环素类药
• 发布时间：2018-02-15 08:00:00
• 更新时间：2025-08-24 18:58:12

名称

• 中文名: 甲烯土霉素
• 英文名: methacycline
• 中文别名: 多西环素杂质B; 强力霉素(多西环素)杂质B,美他环素; 甲基阿昔洛韦; 美他环素; 盐酸多西环素杂质B; 强力霉素杂质B; 强力霉素杂质2(强力霉素杂质B)
• 英文别名: 12aalpha))-ph; 6-methylene-oxytetracyclin; Cyclobiotic; 6-Methyleneoxytetracycline, Metacycline, RondoMycin; methacyclinebase; 6-deoxy-6-demethyl-6-methylene-5-oxytetracycline; 2-Naphthacenecboxamide,4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,5,10,12,12a-pentahydroxy-6-methylene-1,11-dioxo-,(4S,4,5S,5,12aS); Metacyclin; (4S,4,5S,5,12aS)-4-(Dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,5,10,12,12a-pentahydroxy-6-methylene-1,11-dioxo-2-naphthacenecboxamide; methacyclineamphoteric; Germicilclin; MetacyclineQ: What is Metacycline Q: What is the CAS Number of Metacycline Q: What is the storage condition of Metacycline; Adriamicina; bialatan; gs-2876; 6-methylene-5-hydroxytetracycline; Doxycycline Impurity B/Metacycline; 10,12,12a-pentahydroxy-6-methylene-1,11-dioxo; Doxycycline Monohydrate Impurity B,Metacycline; METHACYCLINE; 10,12,12a-pentahydroxy-6-methylene-1,11-dioxo-,(4s-(4alpha,4aalpha,5alpha,5aal; 6-methylene-5-oxytetracycline; METHACYCLINE //BP; 6-demethyl-6-deoxy-5-hydroxy-6-methylenetetracycline; metacycline; Doxycycline impurity B; rondomycin; Doxycycline Impurity 2(Doxycycline Impurity B); tri-methacycline; tetrabutylazanium,2,4,6-trinitrophenolate; 6-methyleneoxytetracycline; Globociclina

物化性质

• 密度: 1.66g/cm3
• 沸点: 695.1ºC at 760mmHg
• 熔点: >150°C (dec.) (lit.)
• 分子式: C₂₂H₂₂N₂O₈
• 分子量: 442.41900
• 闪点: 374.2ºC
• 精确质量: 442.13800
• PSA: 181.62000
• LogP: 0.26240
• 外观性状: 黄色至棕色固体
• 折射率: 1.753
• 储存条件: 2-8°C

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : QI9275000 CHEMICAL NAME : 2-Naphthacenecarboxamide, 4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro- 3,5,10,12,12a-pentahydroxy-6-methylene-1,11-dioxo- CAS REGISTRY NUMBER : 914-00-1 LAST UPDATED : 199506 DATA ITEMS CITED : 3 MOLECULAR FORMULA : C22-H22-N2-O8 MOLECULAR WEIGHT : 442.46 WISWESSER LINE NOTATION : L E6 C666 BV FV MY CU GU LHTT&&J DQ EQ GVZ HQ IN1&1 KQ MU1 RQ HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 660 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value MUTATION DATA TYPE OF TEST : DNA inhibition TEST SYSTEM : Human Lymphocyte DOSE/DURATION : 3750 ug/L REFERENCE : BCPHBM British Journal of Clinical Pharmacology. (Blackwell Scientific Pub. Ltd., POB 88, Oxford, UK) V.1- 1974- Volume(issue)/page/year: 16,127,1983 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X1538 No. of Facilities: 11 (estimated) No. of Industries: 1 No. of Occupations: 5 No. of Employees: 1150 (estimated) No. of Female Employees: 591 (estimated)