29560-58-5

• 常用中文名：盐酸莫雷西嗪
• 常用英文名：MORACIZINE HYDROCHLORIDE
• CAS号：29560-58-5
• 分子式：C₂₂H₂₆ClN₃O₄S
• 分子量：463.97800
• 相关类别： 研究领域 心血管疾病
• 发布时间：2018-06-28 16:29:24
• 更新时间：2024-01-02 12:32:26
• 盐酸莫里西嗪(EN 313)是一种口服活性I类抗心律失常剂。盐酸莫里西嗪降低了0相去极化的最大速率；增加第2阶段和第3阶段复极的速率,减少动作电位持续时间,并减少有效不应期[1]。

名称

• 中文名: 盐酸莫雷西嗪
• 英文名: moricizine hydrochloride
• 英文别名: Moracizin-HCl; ethmozoine hydrochloride; Etmozin; Moricizine HCl; Ethmosine; UNII-71OK3Z1ESP; Ethmozin; ethyl N-[10-(3-morpholin-4-ylpropanoyl)phenothiazin-2-yl]carbamate,hydrochloride; Moracizine hydrochloride; EN 313; MORICIZINE HYDROCHLORIDE; Ethmozine

物化性质

• 沸点: 625ºC at 760 mmHg
• 分子式: C₂₂H₂₆ClN₃O₄S
• 分子量: 463.97800
• 闪点: 331.8ºC
• 精确质量: 463.13300
• PSA: 96.41000
• LogP: 4.98450
• 外观性状: 白色至黄褐色的结晶粉末
• 蒸汽压: 1.54E-15mmHg at 25°C

生物活性

• 描述: 盐酸莫里西嗪(EN 313)是一种口服活性I类抗心律失常剂。盐酸莫里西嗪降低了0相去极化的最大速率；增加第2阶段和第3阶段复极的速率,减少动作电位持续时间,并减少有效不应期[1]。
• 相关类别:
  研究领域 >> 心血管疾病
  信号通路 >> 其他 >> 其他
• 参考文献:

  [1]. Bigger JT Jr. Cardiac electrophysiologic effects of moricizine hydrochloride. Am J Cardiol. 1990 Feb 20;65(8):15D-20D; discussion 68D-71D.

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : SN6500000 CHEMICAL NAME : Phenothiazine-2-carbamic acid, 10-(3-morpholinopropionyl)-, ethyl ester, hydrochloride CAS REGISTRY NUMBER : 29560-58-5 LAST UPDATED : 199803 DATA ITEMS CITED : 7 MOLECULAR FORMULA : C22-H25-N3-O4-S.Cl-H MOLECULAR WEIGHT : 464.02 WISWESSER LINE NOTATION : T C666 BN ISJ EMVO2 B2V- AT6N DOTJ &GH HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 1 gm/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : FATOAO Farmakologiya i Toksikologiya (Moscow). For English translation, see PHTXA6 and RPTOAN. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.2- 1939- Volume(issue)/page/year: 53(3),30,1990 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 105 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : FATOAO Farmakologiya i Toksikologiya (Moscow). For English translation, see PHTXA6 and RPTOAN. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.2- 1939- Volume(issue)/page/year: 48(1),60,1985 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 11 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : FATOAO Farmakologiya i Toksikologiya (Moscow). For English translation, see PHTXA6 and RPTOAN. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.2- 1939- Volume(issue)/page/year: 53(3),30,1990 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 131 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : RPTOAN Russian Pharmacology and Toxicology (English Translation). Translation of FATOAO. (Euromed Pub., 33, Woodlands Rd., Surbiton, Surrey, UK) V.30- 1967- Volume(issue)/page/year: 35,74,1972 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 31 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : PCJOAU Pharmaceutical Chemistry Journal (English Translation). Translation of KHFZAN. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) No.1- 1967- Volume(issue)/page/year: 11,640,1977 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Unreported SPECIES OBSERVED : Mammal - species unspecified DOSE/DURATION : 12 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : FATOAO Farmakologiya i Toksikologiya (Moscow). For English translation, see PHTXA6 and RPTOAN. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.2- 1939- Volume(issue)/page/year: 48(5),43,1985

安全

• 海关编码: 2934999090

合成路线

34749-22-9 ~% 29560-58-5

文献：Pharmaceutical Chemistry Journal, , vol. 20, # 4 p. 279 - 282 Khimiko-Farmatsevticheskii Zhurnal, , vol. 20, # 4 p. 485 - 488

110-91-8 94989-94-3 ~53% 29560-58-5

文献：Gritsenko, A. N.; Skoldinov, A. P. Pharmaceutical Chemistry Journal, 1986 , vol. 20, # 4 p. 279 - 282 Khimiko-Farmatsevticheskii Zhurnal, 1986 , vol. 20, # 4 p. 485 - 488

37711-29-8 ~% 29560-58-5

文献：Pharmaceutical Chemistry Journal, , vol. 20, # 4 p. 279 - 282 Khimiko-Farmatsevticheskii Zhurnal, , vol. 20, # 4 p. 485 - 488

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海关

海关编码	2934999090
中文概述	2934999090. 其他杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
申报要素	品名, 成分含量, 用途
Summary	2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%