1405-90-9

• 常用中文名：Amphotericin B, 8,9-dideoxy-10-hydroxy-7-oxo-
• 常用英文名：Amphotericin B, 8,9-dideoxy-10-hydroxy-7-oxo-
• CAS号：1405-90-9
• 分子式：C₄₇H₇₁NO₁₇
• 分子量：922.06300
• 发布时间：2016-06-19 08:15:41
• 更新时间：2024-09-19 23:57:33

名称

• 英文名: (4E,6E,8E,10E,12E,14E,16E)-3-(4-amino-3,5-dihydroxy-6-methyloxan-2-yl)oxy-19,25,27,32,33,35,37-heptahydroxy-18,20,21-trimethyl-23,29-dioxo-22,39-dioxabicyclo[33.3.1]nonatriaconta-4,6,8,10,12,14,16-heptaene-38-carboxylic acid
• 英文别名: EINECS 215-788-3; CANDIDIN; 8,9-Dideoxy-10-hydroxy-7-oxoamphotericin B; Amphotericin B,8,9-dideoxy-10-hydroxy-7-oxo

物化性质

• 分子式: C₄₇H₇₁NO₁₇
• 分子量: 922.06300
• 精确质量: 921.47200
• PSA: 316.45000
• LogP: 1.62020
• 折射率: 1.601

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : EX4375000 CHEMICAL NAME : Candidin CAS REGISTRY NUMBER : 1405-90-9 LAST UPDATED : 199210 DATA ITEMS CITED : 4 MOLECULAR FORMULA : C46-H71-N-O17 MOLECULAR WEIGHT : 910.18 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 100 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : 85GDA2 "CRC Handbook of Antibiotic Compounds," Vols.1- , Berdy, J., Boca Raton, FL, CRC Press, 1980- Volume(issue)/page/year: 2,288,1980 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 7 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : 85KYAH "Merck Index; an Encyclopedia of Chemicals, Drugs, and Biologicals", 11th ed., Rahway, NJ 07065, Merck & Co., Inc. 1989 Volume(issue)/page/year: 11,263,1989 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 30 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : 85KYAH "Merck Index; an Encyclopedia of Chemicals, Drugs, and Biologicals", 11th ed., Rahway, NJ 07065, Merck & Co., Inc. 1989 Volume(issue)/page/year: 11,263,1989 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 1500 ug/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : 85KYAH "Merck Index; an Encyclopedia of Chemicals, Drugs, and Biologicals", 11th ed., Rahway, NJ 07065, Merck & Co., Inc. 1989 Volume(issue)/page/year: 11,263,1989