55477-19-5

• 常用中文名：Iprozilamine
• 常用英文名：Iprozilamine
• CAS号：55477-19-5
• 分子式：C₁₃H₂₂ClN₅S
• 分子量：315.86500
• 发布时间：2017-06-05 16:54:39
• 更新时间：2024-01-17 14:54:23

名称

• 英文名: 4-chloro-6-(4-methylpiperazin-1-yl)-5-methylsulfanyl-N-propan-2-ylpyrimidin-2-amine
• 英文别名: Iprozilamine [INN]; [4-chloro-6-(4-methyl-piperazin-1-yl)-5-methylsulfanyl-pyrimidin-2-yl]-isopropyl-amine; Iprozilamina [INN-Spanish]; Iprozilaminum; 4-Chloro-2-isopropylamino-6-(4-methylpiperazino)-5-methylthiopyrimidine; 2-Isopropylamino-4-(4-methylpiperazino)-5-methylmercapto-6-chlorpyrimidin; Pyrimidine,4-chloro-2-isopropylamino-6-(4-methylpiperazino)-5-methylthio; Iprozilaminum [INN-Latin]; Iprozilamina; Iprozilamine; 2-Isopropylamino-4-methylpiperazino-6-chloro-5-methylthio-pyrimidine

物化性质

• 密度: 1.26g/cm3
• 沸点: 449.7ºC at 760 mmHg
• 分子式: C₁₃H₂₂ClN₅S
• 分子量: 315.86500
• 闪点: 225.8ºC
• 精确质量: 315.12800
• PSA: 69.59000
• LogP: 2.49990
• 折射率: 1.605

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : UV8111000 CHEMICAL NAME : Pyrimidine, 4-chloro-2-isopropylamino-6-(4-methylpiperazino)-5-me thylthio- CAS REGISTRY NUMBER : 55477-19-5 BEILSTEIN REFERENCE NO. : 0674548 LAST UPDATED : 199703 DATA ITEMS CITED : 2 MOLECULAR FORMULA : C13-H22-Cl-N5-S MOLECULAR WEIGHT : 315.91 WISWESSER LINE NOTATION : T6N DNTJ A1 D- DT6N CNJ BMY1&1 ES1 FG HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 455 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 18,553,1975 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 75 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 18,553,1975

合成路线

109-01-3 40765-76-2 ~% 55477-19-5

文献：Gueremy, Claude; Audiau, Francois; Uzan, Andre; Fur, Gerard Le; Leger, Jean-Michel; Carpy, Alain Journal of Medicinal Chemistry, 1982 , vol. 25, # 12 p. 1459 - 1465

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