110311-27-8

• 常用中文名：磺氯苯脲
• 常用英文名：Sulofenur
• CAS号：110311-27-8
• 分子式：C₁₆H₁₅ClN₂O₃S
• 分子量：350.82000
• 发布时间：2018-03-27 08:00:00
• 更新时间：2025-08-25 19:47:00

名称

• 中文名: 磺氯苯脲
• 英文名: 1-(4-chlorophenyl)-3-(2,3-dihydro-1H-inden-5-ylsulfonyl)urea
• 英文别名: N-(5-Indansulfonyl)-N'-(4-chlorophenyl)urea; SULOFENUR; Sulofenurum [INN-Latin]; N-[[(4-chlorophenyl)amino]carbonyl]-indan-5-sulfonamide; N-(Indanyl-5-sulfonyl)-N'-(4-chlorophenyl)urea; N-([(4-chlorophenyl)amino]carbonyl)-2,3-dihydro-1H-indene-5-sulfonamide; 1-(p-Chlorophenyl)-3-(5-indanylsulfonyl)urea

物化性质

• 密度: 1.449g/cm3
• 分子式: C₁₆H₁₅ClN₂O₃S
• 分子量: 350.82000
• 精确质量: 350.04900
• PSA: 83.65000
• LogP: 4.88380
• 折射率: 1.656

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : NK8730000 CHEMICAL NAME : 1H-Indene-5-sulfonamide, 2,3-dihydro-N-(((4-chlorophenyl)amino)carbonyl)- CAS REGISTRY NUMBER : 110311-27-8 LAST UPDATED : 199612 DATA ITEMS CITED : 4 MOLECULAR FORMULA : C16-H15-Cl-N2-O3-S MOLECULAR WEIGHT : 350.84 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : >1 gm/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : DRFUD4 Drugs of the Future. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1975/76- Volume(issue)/page/year: 16,517,1991 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : >1 gm/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : DRFUD4 Drugs of the Future. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1975/76- Volume(issue)/page/year: 16,517,1991 ** REPRODUCTIVE DATA ** TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral DOSE : 2940 mg/kg SEX/DURATION : male 14 week(s) pre-mating TOXIC EFFECTS : Reproductive - Paternal Effects - spermatogenesis (incl. genetic material, sperm morphology, motility, and count) Reproductive - Paternal Effects - testes, epididymis, sperm duct REFERENCE : REPTED Reproductive Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1987- Volume(issue)/page/year: 6,47,1992 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral DOSE : 2940 mg/kg SEX/DURATION : male 14 week(s) pre-mating TOXIC EFFECTS : Reproductive - Fertility - male fertility index (e.g. # males impregnating females per # males exposed to fertile nonpregnant females) Reproductive - Fertility - pre-implantation mortality (e.g. reduction in number of implants per female; total number of implants per corpora lutea) REFERENCE : REPTED Reproductive Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1987- Volume(issue)/page/year: 6,47,1992

安全

• 海关编码: 2935009090

合成路线

35203-93-1 104-12-1 ~76% 110311-27-8

文献：Howbert; Grossman; Crowell; Rieder; Harper; Kramer; Tao; Aikins; Poore; Rinzel; Grindey; Shaw; Todd Journal of Medicinal Chemistry, 1990 , vol. 33, # 9 p. 2393 - 2407

52405-96-6 106-47-8 ~86% 110311-27-8

文献：Howbert; Grossman; Crowell; Rieder; Harper; Kramer; Tao; Aikins; Poore; Rinzel; Grindey; Shaw; Todd Journal of Medicinal Chemistry, 1990 , vol. 33, # 9 p. 2393 - 2407

52205-86-4 106-47-8 ~% 110311-27-8

文献：Eli Lilly and Company Patent: US5116874 A1, 1992 ;

上下游产品

上游产品  4
35203-93-1 104-12-1 52405-96-6 106-47-8
下游产品  0

海关

海关编码	2935009090
中文概述	2935009090 其他磺（酰）胺. 增值税率:17.0% 退税率:9.0% 监管条件:无 最惠国关税:6.5% 普通关税:35.0%
申报要素	品名, 成分含量, 用途
Summary	2935009090 other sulphonamides VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:35.0%