123482-22-4

• 常用中文名：扎托司琼
• 常用英文名：5-CHLORO-2,2-DIMETHYL-N-(8-METHYL-8-AZABICYCLO[3.2.1]OCTAN-3-YL)-2,3-DIHYDROBENZOFURAN-7-CARBOXAMIDE
• CAS号：123482-22-4
• 分子式：C₁₉H₂₅ClN₂O₂
• 分子量：348.86700
• 发布时间：2018-07-14 22:02:07
• 更新时间：2026-08-21 11:52:32

名称

• 中文名: 扎托司琼
• 英文名: 5-chloro-2,2-dimethyl-N-(8-methyl-8-azabicyclo[3.2.1]octan-3-yl)-3H-1-benzofuran-7-carboxamide
• 英文别名: LY-277359; 7-Benzofurancarboxamide,5-chloro-2,3-dihydro-2,2-dimethyl-N-(8-methyl-8-azabicyclo(3.2.1)oct-3-yl)-,endo; ZATOSETRON; 7-Benzofurancboxamide, 5-chloro-2,3-dihydro-2,2-dimethyl-N-(8-methyl-8-azabicyclo(3.2.1)oct-3-yl)-, endo; Zatosetron; UNII-901MC95XSB; 5-Chloro-2,3-dihydro-2,2-dimethyl-N-[(1β,5β)-8-methyl-8-azabicyclo[3.2.1]octan-3α-yl]benzofuran-7-cboxamide; Zatosetronum; Zatosetron [INN:BAN]; 7-Benzofurancboxamide, 5-chloro-2,3-dihydro-2,2-dimethyl-N-[(3-endo)-8-methyl-8-azabicyclo[3.2.1]oct-3-yl]; Zatosetronum [inn-latin]; ZATOSETRON(WXG02200); 5-chloro-2,2-dimethyl-N-((1R,3r,5S)-8-methyl-8-azabicyclo[3.2.1]octan-3-yl)-2,3-dihydrobenzofuran-7-cboxamide; Zatosetronum [INN-Latin]; 5-chloro-2,2-dimethyl-N-(8-methyl-8-azabicyclo[3.2.1]octan-3-yl)-3H-1-benzofuran-7-cboxamide; Zatosetron [inn:ban]; 123-5 (Maleate)

物化性质

• 密度: 1.26g/cm3
• 沸点: 435.1ºC at 760mmHg
• 分子式: C₁₉H₂₅ClN₂O₂
• 分子量: 348.86700
• 闪点: 216.9ºC
• 精确质量: 348.16000
• PSA: 41.57000
• LogP: 3.73730
• 蒸汽压: 8.99E-08mmHg at 25°C
• 折射率: 1.604

合成路线

321-14-2 ~% 123482-22-4

文献：Robertson, David W.; Lacefield, William B.; Bloomquist, William; Pfeifer, William; Simon, Richard L.; Cohen, Marlene L. Journal of Medicinal Chemistry, 1992 , vol. 35, # 2 p. 310 - 319

4068-78-4 ~% 123482-22-4

文献：Robertson, David W.; Lacefield, William B.; Bloomquist, William; Pfeifer, William; Simon, Richard L.; Cohen, Marlene L. Journal of Medicinal Chemistry, 1992 , vol. 35, # 2 p. 310 - 319

123656-27-9 ~% 123482-22-4

文献：Robertson, David W.; Lacefield, William B.; Bloomquist, William; Pfeifer, William; Simon, Richard L.; Cohen, Marlene L. Journal of Medicinal Chemistry, 1992 , vol. 35, # 2 p. 310 - 319

136954-97-7 ~% 123482-22-4

文献：Robertson, David W.; Lacefield, William B.; Bloomquist, William; Pfeifer, William; Simon, Richard L.; Cohen, Marlene L. Journal of Medicinal Chemistry, 1992 , vol. 35, # 2 p. 310 - 319

136954-96-6 ~% 123482-22-4

文献：Robertson, David W.; Lacefield, William B.; Bloomquist, William; Pfeifer, William; Simon, Richard L.; Cohen, Marlene L. Journal of Medicinal Chemistry, 1992 , vol. 35, # 2 p. 310 - 319

189308-64-3 87571-88-8 ~% 123655-68-5 123482-22-4

文献：Robertson, David W.; Lacefield, William B.; Bloomquist, William; Pfeifer, William; Simon, Richard L.; Cohen, Marlene L. Journal of Medicinal Chemistry, 1992 , vol. 35, # 2 p. 310 - 319

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