60-91-3

• 常用中文名：二乙嗪
• 常用英文名：diethazine
• CAS号：60-91-3
• 分子式：C₁₈H₂₂N₂S
• 分子量：298.44600
• 相关类别： 原料药 神经系统用药 抗震颤麻痹药
• 发布时间：2018-04-06 08:00:00
• 更新时间：2024-01-14 17:30:32

名称

• 中文名: 二乙嗪
• 英文名: N,N-diethyl-2-phenothiazin-10-ylethanamine
• 英文别名: Fourneau 2987; Diethazine [INN:BAN]; Lodibon; Diethazine; Dolisina; Casantin [German]; Diaethazinum; diethyl-(2-phenothiazin-10-yl-ethyl)-amine; N,N-diethyl-10H-phenothiazine-10-ethanamine; Diaethyl-(2-phenothiazin-10-yl-aethyl)-amin; Eazamine; Diethazinum [INN-Latin]; Dietazina [INN-Spanish]; 10-[2-(diethylamino)ethyl]phenothiazine

物化性质

• 密度: 1.115g/cm3
• 沸点: 422.2ºC at 760 mmHg
• 分子式: C₁₈H₂₂N₂S
• 分子量: 298.44600
• 闪点: 209.1ºC
• 精确质量: 298.15000
• PSA: 31.78000
• LogP: 4.69610
• 折射率: 1.608
• 计算化学:

  1.疏水参数计算参考值（XlogP）:无

  2.氢键供体数量:0

  3.氢键受体数量:3

  4.可旋转化学键数量:5

  5.互变异构体数量:无

  6.拓扑分子极性表面积:31.8

  7.重原子数量:21

  8.表面电荷:0

  9.复杂度:296

  10.同位素原子数量:0

  11.确定原子立构中心数量:0

  12.不确定原子立构中心数量:0

  13.确定化学键立构中心数量:0

  14.不确定化学键立构中心数量:0

  15.共价键单元数量:1

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : SO4200000 CHEMICAL NAME : Phenothiazine, 10-(2-(diethylamino)ethyl)- CAS REGISTRY NUMBER : 60-91-3 LAST UPDATED : 199706 DATA ITEMS CITED : 6 MOLECULAR FORMULA : C18-H22-N2-S MOLECULAR WEIGHT : 298.48 WISWESSER LINE NOTATION : T C666 BN ISJ B2N2&2 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 28500 ug/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 103,371,1955 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 450 mg/kg TOXIC EFFECTS : Behavioral - tremor Behavioral - rigidity (including catalepsy) REFERENCE : AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 134,255,1961 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 225 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 4,171,1954 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 450 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : PSCBAY Psychopharmacology Service Center, Bulletin. (Bethesda, MD) V.1-3, 1961-65. For publisher information, see PSYBB9. Volume(issue)/page/year: 2,17,1963 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 56 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : HPPAAL Helvetica Physiologia et Pharmacologica Acta. (Basel, Switzerland) V.1-26, 1943-68. Discontinued. Volume(issue)/page/year: 16,277,1958 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - rabbit DOSE/DURATION : 20 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 120,450,1959

安全

• 海关编码: 2934300000

海关

海关编码	2934300000
中文概述	2934300000. 含一个吩噻嗪环系的化合物(吩噻嗪环系不论是否氢化,化合物未经进一步稠合的 ). 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
申报要素	品名, 成分含量, 用途
Summary	2934300000. other compounds containing in the structure a phenothiazine ring-system (whether or not hydrogenated), not further fused. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%