112953-11-4

• 常用中文名：UCN-01,PKC抑制剂
• 常用英文名：UCN-01
• CAS号：112953-11-4
• 分子式：C₂₈H₂₆N₄O₄
• 分子量：482.53000
• 发布时间：2017-11-30 07:08:43
• 更新时间：2026-07-08 19:03:46
• UCN-01 (7-Hydroxystaurosporine.

名称

• 中文名: UCN-01,PKC抑制剂
• 英文名: 7-Hydroxystaurosporine
• 中文别名: 抗生素 UCN-01; (5S,6R,7R,9R,16R)-16-羟基-6-甲氧基-5-甲基-7-(甲胺基)-6,7,8,9,15,16-六氢-17-氧杂-4B,9A,15-三氮杂-5,9-甲桥二苯并[B,H]环壬[JKL]环戊基[E]-AS-INDACEN-14(5H)-酮
• 英文别名: (9S)-2,3,10,11,12,13-Hexahydro-3α-hydroxy-10α-methoxy-9-methyl-11α-methylamino-9β,13β-oxy-1H,9H-diindolo[1,2,3-gh:3',2',1'-lm]pyrrolo[3,4-j][1,7]benzodiazonin-1-one; UNC 01; KRX-0601，UCN-01; (3R,9S,10R,11R,13R)-2,3,10,11,12,13-Hexahydro-3-hydroxy-10-methoxy-9-methyl-11-(methylamino)-9,13-oxy-1H,9H-diindolo1,2,3-gh:3',2',1'-lMpyrrolo3,4-j1,7benzodiazonin-1-one; 9,13-oxy-1H,9H-diindolo[1,2,3-gh:3',2',1'-lM]pyrrolo[3,4-j][1,7]benzodiazonin-1-one, 2,3,10,11,12,13-hexahydro-3-hydroxy-10-Methoxy-9-Methyl-11-(MethylaMino)-, (3R,9S,10R,11R,13R); KRX-0601; 7-hydroxystaurosporine; (5S,6R,7R,9R,16R)-16-Hydroxy-6-methoxy-5-methyl-7-(methylamino)-6,7,8,9,15,16-hexahydro-17-oxa-4b,9a,15-triaza-5,9-methanodibenzo[b,h]cyclonona[jkl]cyclopenta[e]-as-indacen-14(5H)-one; 1okz; UCN01,UCN 01; KW-2401; (5S,6R,7R,9R,16R)-16-Hydroxy-6-methoxy-5-methyl-7-(methylamino)-6,7,8,9,15,16-hexahydro-17-oxa

物化性质

• 密度: 1.63g/cm3
• 沸点: 705.7ºC at 760mmHg
• 分子式: C₂₈H₂₆N₄O₄
• 分子量: 482.53000
• 闪点: 380.6ºC
• 精确质量: 482.19500
• PSA: 89.68000
• LogP: 4.56460
• 外观性状: 浅黄色固体
• 蒸汽压: 6.64E-21mmHg at 25°C
• 折射率: 1.827
• 储存条件: -20°C

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : KC6600010 CAS REGISTRY NUMBER : 112953-11-4 LAST UPDATED : 199312 DATA ITEMS CITED : 1 MOLECULAR FORMULA : C28-H26-N4-O4 MOLECULAR WEIGHT : 482.58 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 25 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : JANTAJ Journal of Antibiotics. (Japan Antibiotics Research Assoc., 2-20-8 Kamiosaki, Shinagawa-ku, Tokyo, 141, Japan) V.2-5, 1948-52; V.21- 1968- Volume(issue)/page/year: 42,571,1989

安全

• 危险品运输编码: NONH for all modes of transport
• RTECS号: KC6600010