38128-86-8

• 常用中文名：NCI 143-468
• 常用英文名：NCI 143-468
• CAS号：38128-86-8
• 分子式：C₄₆H₅₆N₂O₁₃
• 分子量：844.94200
• 发布时间：2016-06-21 05:21:21
• 更新时间：2024-04-08 19:16:22

名称

• 英文名: Rifamycin AF/01
• 英文别名: 3-Formylrifamycin-SV-O-phenylaethylenoxim; 3-Formylrifamycin-SV-O-p-Brombenzyloxim; rifaldehyde O-phenethyl-oxime

物化性质

• 密度: 1.33g/cm3
• 分子式: C₄₆H₅₆N₂O₁₃
• 分子量: 844.94200
• 精确质量: 844.37800
• PSA: 222.90000
• LogP: 6.48530
• 折射率: 1.626

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : KD1881000 CHEMICAL NAME : 2,7-(Epoxypentadeca(1,11,13)trienimino)naphtho(2,1-b) furan-1,11(2H)-dione, 3-formyl-5,6,9, 17,19,21-hexahydroxy-23-methoxy-2,4,12,16,18,20,22-he ptamethyl-, 21-acetate, O-phenethyloxime CAS REGISTRY NUMBER : 38128-86-8 LAST UPDATED : 199612 DATA ITEMS CITED : 1 MOLECULAR FORMULA : C46-H56-N2-O13 MOLECULAR WEIGHT : 845.04 WISWESSER LINE NOTATION : T C6 B65-24- A D E 2BC G& AV LO NO F&VM OU B&U D&U MH&&&TJ DQ E1UNO2R& GQ IQ J1 M1 QO1 R1 SOV HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 77 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 17,396,1974

合成路线

4732-11-0 13292-22-3 ~% 38128-86-8

文献：Cricchio; Lancini; Tamborini; Sensi Journal of Medicinal Chemistry, 1974 , vol. 17, # 4 p. 396 - 403

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