500-42-5

• 常用中文名：氯拉扎尼
• 常用英文名：Chlorazanil
• CAS号：500-42-5
• 分子式：C₉H₈ClN₅
• 分子量：221.64600
• 相关类别： 研究领域 代谢疾病
• 发布时间：2018-09-14 17:42:58
• 更新时间：2026-07-06 12:53:41
• Chlorazanil 是一种三嗪衍生物,也是一种新型非毒性利尿剂。

名称

• 中文名: 氯拉扎尼
• 英文名: 2-N-(4-chlorophenyl)-1,3,5-triazine-2,4-diamine
• 中文别名: 氯嗪醛; 1,3,5-三嗪-2,4-二胺,N-(4-氯苯基); N-(4-氯苯基)-1,3,5-三嗪-2,4-二胺单盐酸盐; S-三嗪,2-氨基-4-(对; N-(4-氯苯基)-1,3,5-三嗪-2,4-二胺; 2-氨基-4-(4-氯苯胺基)-S-三嗪; 2-氨基-4-(对-氯苯胺基)-S-三嗪; 2-氨基-4-对-氯苯胺基-S-三嗪盐酸盐; 盐酸盐氯拉扎尼; 2-(4-氯苯基氨基)-4-氨基-1,3,5-三嗪; (4-氨基-S-三嗪-2-基)-(4-氯苯基)胺; 氯苯二胺三嗪
• 英文别名: N-(4-Chlorophenyl)-1,3,5-triazine-2,4-diamine; N-(4-chloro-phenyl)-[1,3,5]triazine-2,4-diamine; SKF-3195; N2-(4-chloro-phenyl)-[1,3,5]triazine-2,4-diyldiamine; Riker 545; L-Mimosine (leucenol); Chlorazinil; Orpizin; Riker; 1,3,5-Triazine-2,4-diamine, N-(4-chlorophenyl); Chloroazinal; 1,3,5-Triazine-2,4-diamine, N-(4-chlorophenyl)- (9CI); Diurazine; Triazurol; 2-Amino-4-(4-chloroanilino)-S-triazine; Neo-Urofort; (4-amino-s-triazin-2-yl)-(4-chlorophenyl)amine; 2-(4-Chlorophenylamino)-4-amino-1,3,5-triazine; 2-AMINO-4-(P-CHLOROANILINO)-S-TRIAZINE; chlorazanil; 2-Amino-4-p-chloroanilino-s-triazine hydrochloride; neo-Urofort; Daquin; N2-(4-Chlor-phenyl)-[1,3,5]triazin-2,4-diyldiamin; Neurofort; 1,3,5-Triazine-2,4-diamine, N2-(4-chlorophenyl)

物化性质

• 密度: 1.483g/cm3
• 沸点: 457.2ºC at 760mmHg
• 分子式: C₉H₈ClN₅
• 分子量: 221.64600
• 闪点: 230.3ºC
• 精确质量: 221.04700
• PSA: 76.72000
• LogP: 2.50500
• 折射率: 1.72
• 储存条件: 2-8℃

生物活性

• 描述: Chlorazanil 是一种三嗪衍生物,也是一种新型非毒性利尿剂。
• 相关类别:
  信号通路 >> 其他 >> 其他
  研究领域 >> 代谢疾病
• 参考文献:

  [1]. Thevis M, et al. Formation of the diuretic chlorazanil from the antimalarial drug proguanil--implications for sports drug testing. J Pharm Biomed Anal. 2015 Nov 10;115:208-13.

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : XY3150500 CHEMICAL NAME : s-Triazine, 2-amino-4-(p-chloroanilino)- CAS REGISTRY NUMBER : 500-42-5 BEILSTEIN REFERENCE NO. : 0016503 LAST UPDATED : 199707 DATA ITEMS CITED : 3 MOLECULAR FORMULA : C9-H8-Cl-N5 MOLECULAR WEIGHT : 221.67 WISWESSER LINE NOTATION : T6N CN ENJ BZ DMR DG HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 5 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : JACSAT Journal of the American Chemical Society. (American Chemical Soc., Distribution Office Dept. 223, POB 57136, West End Stn., Washington, DC 20037) V.1- 1879- Volume(issue)/page/year: 79,5064,1957 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 16 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 11,350,1961 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 300 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 151,225,1964

安全

• 海关编码: 2933699090

上下游产品

上游产品  5
106-47-8 109-94-4 64-18-6 4022-81-5
5304-59-6
下游产品  0

海关

海关编码	2933699090
中文概述	2933699090 其他结构上含非稠合三嗪环化合物. 增值税率:17.0% 退税率:9.0% 监管条件:无 最惠国关税:6.5% 普通关税:20.0%
申报要素	品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期
Summary	2933699090 other compounds containing an unfused triazine ring (whether or not hydrogenated) in the structure。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:20.0%