749257-78-1

• 常用中文名：1-[3-(Trifluoromethyl)-2-pyridinyl]ethanone
• 常用英文名：1-[3-(Trifluoromethyl)-2-pyridinyl]ethanone
• CAS号：749257-78-1
• 分子式：C₈H₆F₃NO
• 分子量：189.135
• 发布时间：2017-04-06 08:10:11
• 更新时间：2024-01-14 22:06:21

名称

• 英文名: 1-[3-(trifluoromethyl)pyridin-2-yl]ethanone
• 英文别名: 2-acetyl-3-trifluoromethyl-pyridine; 1-(3-trifluoromethyl-2-pyridinyl)ethanone; 1-(3-trifluoromethyl-pyridin-2-yl)-ethanone; Ethanone, 1-[3-(trifluoromethyl)-2-pyridinyl]-; trifluoromethylpyridinylethanone; 1-[3-(Trifluoromethyl)-2-pyridinyl]ethanone

物化性质

• 密度: 1.3±0.1 g/cm3
• 沸点: 214.6±40.0 °C at 760 mmHg
• 分子式: C₈H₆F₃NO
• 分子量: 189.135
• 闪点: 83.6±27.3 °C
• 精确质量: 189.040146
• PSA: 29.96000
• LogP: 2.24
• 蒸汽压: 0.2±0.4 mmHg at 25°C
• 折射率: 1.446

合成路线

406933-21-9 75-16-1 ~81% 749257-78-1

文献：MERCK SHARP and DOHME LIMITED Patent: WO2004/74290 A1, 2004 ; Location in patent: Page 45-46 ; WO 2004/074290 A1

917-64-6 406933-21-9 ~81% 749257-78-1

文献：Blum, Charles A.; Caldwell, Timothy; Zheng, Xiaozhang; Bakthavatchalam, Rajagopal; Capitosti, Scott; Brielmann, Harry; De Lombaert, Stephane; Kershaw, Mark T.; Matson, David; Krause, James E.; Cortright, Daniel; Crandall, Marci; Martin, William J.; Murphy, Beth Ann; Boyce, Susan; Jones, A. Brian; Mason, Glenn; Rycroft, Wayne; Perrett, Helen; Conley, Rachael; Burnaby-Davies, Nicola; Chenard, Bertrand L.; Hodgetts, Kevin J. Journal of Medicinal Chemistry, 2010 , vol. 53, # 8 p. 3330 - 3348

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