103129-81-3

• 常用中文名：氨氯地平
• 常用英文名：d-Amlodipine
• CAS号：103129-81-3
• 分子式：C₂₀H₂₅ClN₂O₅
• 分子量：408.882
• 相关类别： 原料药 循环系统用药 防治心绞痛药
• 发布时间：2016-09-06 06:36:23
• 更新时间：2026-06-30 22:42:51
• (R)-Amlodipine is the R isomer of Amlodipine --- a medication used to lower blood pressure and prevent chest pain.

名称

• 中文名: 氨氯地平
• 英文名: 3-O-ethyl 5-O-methyl (4R)-2-(2-aminoethoxymethyl)-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate
• 中文别名: 3-乙基5-甲基2-[(2-氨基乙氧基)甲基]-4-(2-氯苯基)-6-甲基-1,4-二氢-3,5-吡啶二羧酸酯; 右旋氨氯地平; 氨氯地平杂质15(R异构体); (+)-氨氯地平; 3-乙基 5-甲基 (R)-2-((2-氨基乙氧基)甲基)-4-(2-氯苯基)-6-甲基-1,4-二氢吡啶-3,5-二羧酸酯; 达比加群酰-BETA-D-葡萄糖醛酸盐; 化合物 (R)-AMLODIPINE; R-氨氯地平; 右氨氯地平; 马来酸氨氯地平杂质T; 马来酸左氨氯地平杂质T; (R)-氨氯地平杂质; 氨氯地平R异构体
• 英文别名: 3-O-ethyl 5-O-methyl (4R)-2-(2-aminoethoxymethyl)-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicboxylate; d-Amlodipine,(R)-(+)-Amlodipine; (R)Amlodipine,(R) Amlodipine; AMLODIPINE (R-ISOMER) L TTRATE; (4R)-2-[(2-Aminoethoxy)methyl]-4-(2-chlorophenyl)-3-ethoxycbonyl-5-methoxycbonyl)-6-methyl-1,4-dihydropyridine; (R)-3-ethyl 5-methyl 2-((2-aminoethoxy)methyl)-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicboxylate; Amlodipine Impurity 15; Amlodipine Impurity 15（R-Isomer）; 3,5-Pyridinedicboxylic acid, 2-[(2-aminoethoxy)methyl]-4-(2-chlorophenyl)-1,4-dihydro-6-methyl-, 3-ethyl 5-methyl ester, (R); (R)-Amlodipine; 3-Ethyl 5-Methyl 2-[(2-Aminoethoxy)Methyl]-4-(2-Chlorophenyl)-6-Methyl-1,4-Dihydro-3,5-Pyridinedicboxylate; 06X; UNII-1J444QC288 component HTIQEAQVCYTUBX-QGZVFWFLSA-N; (4R)-2-[(2-AMinoethoxy)Methyl]-4-(2-chlorophenyl)-1,4-dihydro-6-Methyl-3,5-pyridinedicboxylic Acid 3-Ethyl 5-Methyl Ester; (R)-(+)-Amlodipine; Amlodipine (R)-Isomer; (R)-Amlodipine //BP; (R)-3-ethyl-5-metyl-2-((2-aminoethoxy)methyl)-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyrdine-3,5-dicboxylate; R-amlodipine; 3,5-Pyridinedicboxylic acid, 2-[(2-aminoethoxy)methyl]-4-(2-chlorophenyl)-1,4-dihydro-6-methyl-, 3-ethyl 5-methyl ester, (4R)

物化性质

• 密度: 1.228g/cm3
• 沸点: 527.161ºC at 760 mmHg
• 熔点: 101-103°C
• 分子式: C₂₀H₂₅ClN₂O₅
• 分子量: 408.882
• 闪点: 272.617ºC
• PSA: 162.63000
• LogP: 5.30950
• 蒸汽压: 0mmHg at 25°C
• 折射率: 1.546
• 储存条件: -20°C Freezer

合成路线

125639-89-6 ~% 103129-81-3

文献：Journal of Medicinal Chemistry, , vol. 29, # 9 p. 1696 - 1702

103069-49-4 ~% 103129-81-3

文献：Journal of Medicinal Chemistry, , vol. 29, # 9 p. 1696 - 1702

103094-33-3 ~% 103129-81-3

文献：Journal of Medicinal Chemistry, , vol. 29, # 9 p. 1696 - 1702

103069-47-2 ~% 103129-81-3

文献：Journal of Medicinal Chemistry, , vol. 29, # 9 p. 1696 - 1702

103069-48-3 ~% 103129-81-3

文献：Journal of Medicinal Chemistry, , vol. 29, # 9 p. 1696 - 1702

88150-42-9 ~% 103129-81-3 103129-82-4

文献：WO2010/148191 A2, ; Page/Page column 45-49; 59 ;

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