174756-44-6

• 常用中文名：沙芬酰胺对映异构体
• 常用英文名：FCE 28073
• CAS号：174756-44-6
• 分子式：C₁₇H₁₉FN₂O₂
• 分子量：302.34300
• 发布时间：2016-10-04 09:06:00
• 更新时间：2026-07-01 14:17:32

名称

• 中文名: 沙芬酰胺对映异构体
• 英文名: N2-{4-[(3-Fluorobenzyl)oxy]benzyl}-D-alaninamide
• 中文别名: 沙芬酰胺杂质A; (R)-2-(4-(3-氟苄氧基)苄胺基)丙酰胺; 沙芬酰胺杂质02; 藏红花酰胺杂质B; 番红花酰胺杂质B; R-沙芬酰胺,即不含甲磺酸盐
• 英文别名: (2R)-2-[[4-[(3-fluorophenyl)methoxy]phenyl]methylamino]propanamide; FCE 28073, 10 mM in DMSO; (R)-2-[[4-[(3-Fluorobenzyl)oxy]benzyl]amino]propanamide methanesulfonate; Safinamide impurity 7/(R)-2-((4-((3-fluorobenzyl)oxy)benzyl)amino)propanamide; (R)-Safinamide; Propanamide, 2-[[[4-[(3-fluorophenyl)methoxy]phenyl]methyl]amino]-, (2R); (R)-2-((4-((3-fluorobenzyl)oxy)benzyl)amino)propanamide; (R)-2-((4-((3-fluorobenzyl)oxy)benzyl)amino)propanamide/Safinamide impurity; 2-hydroxy-N-propylnorapomorphine hydrobromide; Safinamide (R)-Isomer; Safinamide-2

物化性质

• 分子式: C₁₇H₁₉FN₂O₂
• 分子量: 302.34300
• 精确质量: 302.14300
• PSA: 65.34000
• LogP: 3.90870
• 储存条件: 2-8°C

合成路线

66742-57-2 71810-97-4 ~88% 174756-44-6

文献：NEWRON PHARMACEUTICALS S.P.A. Patent: WO2009/74478 A1, 2009 ; Location in patent: Page/Page column 66 ;

66742-57-2 80222-96-4 ~% 133865-89-1 174756-44-6

文献：NEWRON PHARMACEUTICALS S.P.A. Patent: WO2009/74478 A1, 2009 ; Location in patent: Page/Page column 71-72 ;

66742-57-2 33208-99-0 ~% 133865-89-1 174756-44-6

文献：NEWRON PHARMACEUTICALS S.P.A. Patent: WO2009/74478 A1, 2009 ; Location in patent: Page/Page column 64-65 ;

456-47-3 35661-38-2 211617-68-4 ~% 174756-44-6

文献：Leonetti, Francesco; Capaldi, Carmelida; Pisani, Leonardo; Nicolotti, Orazio; Muncipinto, Giovanni; Stefanachi, Angela; Cellamare, Saverio; Caccia, Carla; Carotti, Angelo Journal of Medicinal Chemistry, 2007 , vol. 50, # 20 p. 4909 - 4916

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