10075-24-8

• 常用中文名：米帕明双羟萘酸盐
• 常用英文名：Imipramine pamoate
• CAS号：10075-24-8
• 分子式：C₆₁H₆₄N₄O₆
• 分子量：949.18400
• 相关类别： 研究领域 神经疾病
• 发布时间：2016-11-28 04:04:15
• 更新时间：2026-07-17 12:52:22
• 二磷酸异丙胺是一种有效的抗抑郁化合物[1][2]。

名称

• 中文名: 丙咪嗪双羟萘酸噻嘧啶
• 英文名: 4-[(3-carboxy-2-hydroxynaphthalen-1-yl)methyl]-3-hydroxynaphthalene-2-carboxylic acid,3-(5,6-dihydrobenzo[b][1]benzazepin-11-yl)-N,N-dimethylpropan-1-amine
• 中文别名: 丙米嗪巴莫酸盐; 帕米酸丙咪嗪
• 英文别名: EINECS 233-206-6; Imipramine embonate; 4,4'-methylenebis[3-hydroxy-2-naphthoic] acid, compound with 10,11-dihydro-N,N-dimethyl-5H-dibenz[b,f]azine-5-propylamine (1:2); 5H-Dibenz(b,f)azepine,5-(3-(dimethylamino)propyl)-10,11-dihydro-,pamoate; 4,4'-methylenebis(3-hydroxy-2-naphthoic) acid,compound with 10,11-dihydro-N,N-dimethyl-5H-dibenz[b,f]azepine-5-propylamine (1:2); 2-Naphthalenecboxylic acid, 4,4'-methylenebis[3-hydroxy-, compd. with 10,11-dihydro-N,N-dimethyl-5H-dibenz[b,f]azine-5-propanamine (1:2); 10,11-Dihydro-N,N-dimethyl-5H-dibenz[b,f]azine-5-propanamine 4,4'-methylenebis[3-hydroxy-2-naphthalenecboxylate] (2:1); Imipramine Pamoate; 4-[(3-cboxy-2-hydroxynaphthalen-1-yl)methyl]-3-hydroxynaphthalene-2-cboxylic acid,3-(5,6-dihydrobenzo[b]benzazin-11-yl)-N,N-dimethylpropan-1-amine; imipramine embonate; Tofranil-pm (TN); 2-Naphthalenecarboxylic acid,4,4'-methylenebis(3-hydroxy-,compd. with 10,11-dihydro-N,N-dimethyl-5H-dibenz(b,f)azepine-5-propanamine (1:2)

物化性质

• 沸点: 642.7ºC at 760 mmHg
• 分子式: C₆₁H₆₄N₄O₆
• 分子量: 949.18400
• 闪点: 356.5ºC
• 精确质量: 948.48300
• PSA: 128.02000
• LogP: 12.27140
• 蒸汽压: 2.13E-17mmHg at 25°C

生物活性

• 描述: 二磷酸异丙胺是一种有效的抗抑郁化合物[1][2]。
• 相关类别:
  信号通路 >> 其他 >> 其他
  研究领域 >> 神经疾病
• 参考文献:

  [1]. Doyle LN. Imipramine pamoate in depression. Psychosomatics. 1975;16(3):129-31.

  [2]. Goldberg HL, et al. Which tricyclic for depressed outpatients, imipramine pamoate or amitriptyline? Dis Nerv Syst. 1977 Oct;38(10):785-9.

合成路线

1357157-28-8 ~58% 10075-24-8

文献：King, Clifford Riley; D'Ambrosio, Stephen G.; Bristol, David W. Patent: US2012/28960 A1, 2012 ; Location in patent: Page/Page column 26 ;

50-49-7 113-52-0 6640-22-8 ~% 10075-24-8

文献：US7718649 B1, ;

130-85-8 ~% 10075-24-8

文献：US2012/28960 A1, ;