1148113-53-4

• 常用中文名：阿瑞吡坦相关物质A
• 常用英文名：(1R,2R,3R)-Aprepitant
• CAS号：1148113-53-4
• 分子式：C₂₃H₂₁F₇N₄O₃
• 分子量：534.427
• 发布时间：2016-02-20 21:28:32
• 更新时间：2026-09-10 19:40:22

名称

• 中文名: 阿瑞吡坦相关物质A
• 英文名: (R,R,R)-Aprepitant
• 中文别名: 瑞匹坦杂质1; 阿瑞匹坦相关化合物A; 阿瑞匹坦杂质04; 3-(((2R,3R)-2-((R)-1-(3,5-二(三氟甲基)苯基)乙氧基)-3-(4-氟苯基)吗啉代)甲基)-1H-1,2,4-三唑-5(4H)-酮; 杂质A((1R,2R,3R)-APRITANT); 5-[[(2R,3R)-2-[(1R)-1-[3,5-二(三氟甲基)苯基]乙氧基]-3-(4-氟苯基)-4-吗啉基]甲基]-1,2-二氢-3H-1,2,4-三唑-3-酮; 阿瑞匹坦(R,R,R)-异构体(阿瑞沙坦杂质41); APRITANT RC A(R,R,R-非对映异构体); 福沙匹坦双葡甲胺INT1-RRR; 阿瑞吡坦相关化合物A; 阿瑞匹坦有关物质A; (1R,2R,3R)-阿瑞匹坦; 阿瑞匹坦非对映异构体2R3R1R; 阿瑞吡坦相关物质A 标准品; 阿瑞匹坦对映体; 阿瑞匹坦杂质E; SM001E(福沙匹坦杂质RRR); 阿瑞匹坦相关物质A; 阿瑞匹坦杂质J; 阿瑞吡坦杂质E; 阿瑞匹坦相关物质A对照品
• 英文别名: Apritant impurity 5/Apritant Impurity E; Apritant Related CoMpound A; Apritant Related Compound A (10 mg) (3-[[(2R,3R)-2-[(R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)morpholino]methyl]-1H-1,2,4-triazol-5(4H)-one); Apritant Related Compound A (3-[[(2R,3R)-2-[(R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fl; ipitant related substance A reference substance; Apritant Impurity E; 5-[[(2R,3R)-2-[(1R)-1-[3,5-Bis(trifluoroMethyl)phenyl]ethoxy]-3-(4-fluorophenyl)-4-Morpholinyl]Methyl]-1,2-dihydro-3H-1,2,4-triazol-3-one; Apritant(R,R,R)-Isomer（Azilstan Impurity 41）; 3H-1,2,4-Triazol-3-one, 5-[[(2R,3R)-2-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)-4-morpholinyl]methyl]-1,2-dihydro; Apritant RRR isomer (diasteomer)-(5-(((2R,3R)-2-((R)-1-(3,5-bis(trifluoromethyl)phenyl) ethoxy)-3-(4-fluorophenyl) morpholino)methyl)-1,2-dihydro-1,2,4-triazol-3-one); Apritant A; Apritant impurity 04; 3-(((2R,3R)-2-((R)-1-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(4-fluorophenyl)morpholino)methyl)-1H-1,2,4-triazol-5(4H)-one; 5-[[(2R,3R)-2-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)morpholin-4-yl]methyl]-1,2-dihydro-1,2,4-triazol-3-one; (1R,2R,3R)-Apritant; Aprepitant Impurity 3; 3-[[(2R,3R)-2-[(R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)morpholino]methyl]-1H-1,2,4-triazol-5(4H)-one ((R,R,R)-Apritant); "1R,2R,2R Apritant"; 5-{[(2R,3R)-2-{(1R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethoxy}-3-(4-fluorophenyl)-4-morpholinyl]methyl}-1,2-dihydro-3H-1,2,4-triazol-3-one; Apritant Impurity E/ (R,R,R)-Apritant; 5-(((2R,3R)-2-((R)-1-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(4-fluorophenyl)morpholino)methyl)-2,4-dihydro-3H-1,2,4-triazol-3-one; Apritant trans-1-enantiomer; Apritant RC A (R,R,R-Diasteromer); (R,R,R)-Apritant; 3-[[(2R,3R)-2-[(R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)morpholino]methyl]-1H

物化性质

• 密度: 1.5±0.1 g/cm3
• 分子式: C₂₃H₂₁F₇N₄O₃
• 分子量: 534.427
• 精确质量: 534.150208
• PSA: 83.50000
• LogP: 4.23
• 折射率: 1.564
• 储存条件: 2-8°C， 密封， 干燥

安全

• 危险品运输编码: NONH for all modes of transport

合成路线

252742-72-6 380499-06-9 ~10% 1148113-53-4

文献：Gangula, Srinivas; Elati, Chandrashekhar R.; Mudunuru, Satish Varma; Nardela, Anitha; Dongamanti, Ashok; Bhattacharya, Apurba; Bandichhor, Rakeshwar Synthetic Communications, 2010 , vol. 40, # 15 p. 2254 - 2268

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