172822-29-6

• 常用中文名：ENT-阿瑞匹坦
• 常用英文名：Ent-Aprepitant
• CAS号：172822-29-6
• 分子式：C₂₃H₂₁F₇N₄O₃
• 分子量：534.42700
• 发布时间：2016-02-11 15:38:09
• 更新时间：2026-07-08 18:41:44

名称

• 中文名: ENT-阿瑞匹坦
• 英文名: 5-[[(2S,3R)-2-[(1S)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)morpholin-4-yl]methyl]-1,2-dihydro-1,2,4-triazol-3-one
• 中文别名: 杂质B (ENT-APRITANT); 阿瑞匹坦相关化合物B; 3-(((2S,3R)-2-((S)-1-(3,5-双(三氟甲基)苯基)乙氧基)-3-(4-氟苯基)吗啉代)甲基)-1H-1,2 ,4-三唑-5(4H)-酮; SRS对映异构体; 福沙匹坦双葡甲胺INT1-SRS; 阿瑞匹坦杂质07; 阿瑞吡坦相关化合物B; 阿瑞匹坦相关物质B; 阿瑞匹坦(S,R,S)-异构体(阿瑞沙坦杂质44); 阿瑞匹坦杂质B; 阿瑞匹坦杂质D; 3-(((2S,3R)-2-((S)-1-(3,5-双(三氟甲基)苯基)乙氧基)-3-(4-氟苯基)吗啉代)甲基)-1H-1,2 ,4-三唑-5(4H)-酮 (阿瑞匹坦杂质); 福沙匹坦对映异构体; 福沙匹坦对映异构体对照品; 阿瑞匹坦杂质M; 阿瑞匹坦对映异构体2S3R1S; 瑞匹坦杂质4; 阿瑞匹坦杂质B(阿瑞吡坦对映异构体); 阿瑞吡坦相关物质B 标准品; 阿瑞匹坦对映异构体; 先进的杂质D; 阿瑞匹坦有关物质B; 5-(((2S,3R)-2-((S)-1-(3,5-双(三氟甲基)苯基)乙氧基)-3-(4-氟苯基)吗啉基)甲基)-1,2-二氢-3H-1,2,4-三唑-3-酮; 阿瑞吡坦相关物质B; 阿瑞吡坦杂质D
• 英文别名: Aprepitant-MK-0869; Apritant Related CoMpound B; Apritant Related Compound B (3-[[(2S,3R)-2-[(S)-1-[3,5-Bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fl; Apritant RC B; 3-[[(2S,3R)-2-[(S)-1-[3,5-Bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)morpholino]methyl]-1H-1,2,4-triazol-5(4H)-one ((S,R,S)-Apritant); Apritant impurity 4/Apritant Impurity D/ent-Apritant; ent-Apritant; Apritant Impurity D; Apritant S,R,S isomer; Apritant Related Compound B (10 mg) (3-[[(2S,3R)-2-[(S)-1-[3,5-Bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)morpholino]methyl]-1H-1,2,4-triazol-5(4H)-one); Apritant B; 3-(((2S,3R)-2-((S)-1-(3,5-Bis(trifluoromethyl)phenyl)ethoxy)-3-(4-fluorophenyl)morpholino)methyl)-1H-1,2,4-triazol-5(4H)-one (Apritant Impurity); ent-Aprepitant; ipitant related substance B; Apritant Impurity 4; Apritant impurity 07; 5-[[(2S,3R)-2-[(1S)-1-[3,5-Bis(trifluoroMethyl)phenyl]ethoxy]-3-(4-fluorophenyl)-4-Morpholinyl]Methyl]-1,2-dihydro-3H-1,2,4-triazol-3-one; [2S-[2α(R*),3α]]-5-[[2-[1-[3,5-Bis(trifluoroMethyl)phenyl]ethoxy]-3-(4-fluorophenyl)-4-Morpholinyl]Me; 3-[[(2S,3R)-2-[(S)-1-[3,5-Bis(trifl; 3H-1,2,4-Triazol-3-one, 5-[[(2S,3R)-2-[(1S)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)-4-morpholinyl]methyl]-1,2-dihydro; Emend; Aprepitant Impurity 1; Apritant R C B; Apritant(S,R,S)-Isomer（Azilstan Impurity 44）; MK0869; 3-[[(2S,3R)-2-[(S)-1-[3,5-Bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)morpholino]methyl]-1H; 5-(((2S,3R)-2-((S)-1-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(4-fluorophenyl)morpholino)methyl)-2,4-dihydro-3H-1,2,4-triazol-3-one

物化性质

• 分子式: C₂₃H₂₁F₇N₄O₃
• 分子量: 534.42700
• 精确质量: 534.15000
• PSA: 83.50000
• LogP: 5.30230

安全

• 危险品运输编码: NONH for all modes of transport

合成路线

327623-37-0 252742-72-6 ~95% 172822-29-6

文献：Gangula, Srinivas; Elati, Chandrashekhar R.; Mudunuru, Satish Varma; Nardela, Anitha; Dongamanti, Ashok; Bhattacharya, Apurba; Bandichhor, Rakeshwar Synthetic Communications, 2010 , vol. 40, # 15 p. 2254 - 2268

1523569-82-5 ~% 172822-29-6

文献：Chinese Chemical Letters, , vol. 24, # 12 p. 1118 - 1122

1523569-83-6 ~% 172822-29-6

文献：Chinese Chemical Letters, , vol. 24, # 12 p. 1118 - 1122

403-42-9 ~% 172822-29-6

文献：Chinese Chemical Letters, , vol. 24, # 12 p. 1118 - 1122

447-43-8 ~% 172822-29-6

文献：Chinese Chemical Letters, , vol. 24, # 12 p. 1118 - 1122

上下游产品

上游产品  5
327623-37-0 252742-72-6 1523569-82-5 403-42-9
447-43-8
下游产品  0