945668-94-0

• 常用中文名：喹硫平二聚物杂质
• 常用英文名：Quetiapine Dimer
• CAS号：945668-94-0
• 分子式：C₃₀H₂₄N₄S₂
• 分子量：504.668
• 发布时间：2018-04-08 08:00:00
• 更新时间：2026-08-15 10:45:33

名称

• 中文名: 喹硫平二聚体
• 英文名: 6-(4-benzo[b][1,4]benzothiazepin-6-ylpiperazin-1-yl)benzo[b][1,4]benzothiazepine
• 中文别名: 奎硫平二聚物; 1,4-双(二苯并[B,F][1,4]噻唑啉-11-基)哌嗪 (喹硫平杂质); 喹硫平杂质D; QUETIAPINE 杂质 D; 喹硫平杂质5(喹硫平杂质D); 杂质D; 富马酸喹硫平杂质D; 富马酸喹硫平杂质 D; 喹硫平杂质15; 喹硫平杂质XI; 喹硫平二聚体杂质
• 英文别名: Quetiapine Fumate Impurity D; Quetiapine Imp D; Quetiapine Impurity 15; Quetiapine Impurity D; Bis(Dibenzothiazinyl) Piperazine; QUETIAPINE IMPURITY D/BIS(DIBENZOTHIAZINYL) PIPERAZINE IMPURITY; Quetiapine Impurity 5(Quetiapine Impurity D); Quetiapine Impurity D/ Quetiapine Dimer Impurity/Quetiapine Bis(dibenzothiazinyl) piperazine Impurity; Quetiapine IMpurity D/Quetiapine DiMer IMpurity; Quetiapine Dimer Impurity; 11,11'-(Piperazine-1,4-diyl)bis(dibenzo[b,f][1,4]thiazine); 11,11'-(1,4-Piperazinediyl)bis(dibenzo[b,f][1,4]thiazepine); Quetiapine fumate Imp. D : 11,11’-Piperazine-1,4-diylbis; Quetiapine DiMer; 11,11'-Piperazine-1,4-diylbis(dibenzo[b,f][1,4]thiazine); Quetiapine Impurity 5; Quetiapine Impurity D/Quetiapine Bis(dibenzothiazinyl) piperazine Impurity (Quetiapine Dimer Impurity); Dibenzo[b,f][1,4]thiazine, 11,11'-(1,4-piperazinediyl)bis; 11,11'-(piperazine-1,4-diyl)bis(dibenzo-[b,f][1,4]thiazine（Quetiapine Impurity D）; 6-(4-benzo[b][1,4]benzothiazin-6-ylpiperazin-1-yl)benzo[b][1,4]benzothiazine; 1,4-Bis(dibenzo[b,f][1,4]thiazin-11-yl)piperazine (Quetiapine Impurity); 11,11'-(1,4-Piperazinediyl)bis-dibenzo[b,f][1,4]thiazine

物化性质

• 密度: 1.3±0.1 g/cm3
• 沸点: 684.7±65.0 °C at 760 mmHg
• 熔点: 291-294°C
• 分子式: C₃₀H₂₄N₄S₂
• 分子量: 504.668
• 闪点: 367.9±34.3 °C
• 精确质量: 504.144226
• PSA: 81.80000
• LogP: 4.86
• 蒸汽压: 0.0±2.1 mmHg at 25°C
• 折射率: 1.748
• 储存条件: 2-8℃

合成路线

110-85-0 13745-86-3 ~% 5747-48-8 945668-94-0

文献：CAMBREX CHARLES CITY, INC. Patent: WO2006/135544 A1, 2006 ; Location in patent: Page/Page column 11 ;

110-85-0 13745-86-3 ~% 945668-94-0

文献：Bharathi; Prabahar; Prasad; Srinivasa Rao; Trinadhachary; Handa; Dandala, Ramesh; Naidu Pharmazie, 2008 , vol. 63, # 1 p. 14 - 19

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