477864-09-8

• 常用中文名：tert-butyl 4-[3-(trifluoromethyl)anilino]piperidine-1-carboxylate
• 常用英文名：tert-butyl 4-[3-(trifluoromethyl)anilino]piperidine-1-carboxylate
• CAS号：477864-09-8
• 分子式：C₁₇H₂₃F₃N₂O₂
• 分子量：344.372
• 发布时间：2017-09-13 14:23:40
• 更新时间：2024-04-04 18:14:50

名称

• 英文名: tert-butyl 4-[3-(trifluoromethyl)anilino]piperidine-1-carboxylate
• 英文别名: 12p-571s; 2-Methyl-2-propanyl 4-{[3-(trifluoromethyl)phenyl]amino}-1-piperidinecarboxylate; 1-Piperidinecarboxylic acid, 4-[[3-(trifluoromethyl)phenyl]amino]-, 1,1-dimethylethyl ester

物化性质

• 密度: 1.2±0.1 g/cm3
• 沸点: 409.8±45.0 °C at 760 mmHg
• 分子式: C₁₇H₂₃F₃N₂O₂
• 分子量: 344.372
• 闪点: 201.7±28.7 °C
• 精确质量: 344.171173
• PSA: 41.57000
• LogP: 4.06
• 蒸汽压: 0.0±1.0 mmHg at 25°C
• 折射率: 1.517

合成路线

98-16-8 87120-72-7 ~56% 477864-09-8

文献：ARES TRADING S.A.; JORAND-LEBRUN, Catherine; SWINNEN, Dominique; GERBER, Patrick; KULKARNI, Santosh Patent: WO2012/130915 A1, 2012 ; Location in patent: Page/Page column 60 ; WO 2012/130915 A1

79099-07-3 98-16-8 ~% 477864-09-8

文献：GLAXO GROUP LIMITED Patent: WO2007/12479 A2, 2007 ; Location in patent: Page/Page column 38 ; WO 2007/012479 A2

401-81-0 87120-72-7 ~% 477864-09-8

文献：Foley, Timothy L.; Rai, Ganesha; Yasgar, Adam; Daniel, Thomas; Baker, Heather L.; Attene-Ramos, Matias; Kosa, Nicolas M.; Leister, William; Burkart, Michael D.; Jadhav, Ajit; Simeonov, Anton; Maloney, David J. Journal of Medicinal Chemistry, 2014 , vol. 57, # 3 p. 1063 - 1078