640-87-9

• 常用中文名：孕甾-4-烯-17α,21-二醇-3,20-二酮-21-醋酸酯
• 常用英文名：reichstein's substance s 21-acetate
• CAS号：640-87-9
• 分子式：C₂₃H₃₂O₅
• 分子量：388.49700
• 发布时间：2019-02-06 15:20:15
• 更新时间：2026-08-08 06:38:34
• 氢化可的松的中间体

名称

• 中文名: 孕甾-4-烯-17Alpha,21-二醇-3,20-二酮-21-醋酸酯
• 英文名: reichstein's substance s 21-acetate
• 中文别名: 氢化可松杂质K; 17A-羟基黄体酮-21-醋酸酯; 20-二酮-21-醋酸酯(RSA); 孕甾-4-烯-17Α,21-二醇-3,20-二酮-21-醋酸酯(氢化可的松杂质); 17A-羟基黄体酮-21-醋酸酯 (RSA); 孕甾-4-烯-17Α,21-二醇-3,20-二酮-21-醋酸酯( RSA ); 17Α-羟基-11-脱氧皮质酮-21-乙酸盐; 17Α,21-二羟基孕甾-4-烯-3,20-二酮-21-醋酸酯; 氢化可的松杂质K; 21-(乙酰氧基)-17-羟基孕-4-烯-3,20-二酮; 4-孕烯-17,21-二醇-3,20-二酮 21-醋酸酯; 17-羟基-21-乙酰氧基孕酮; A氢化可的松杂质K; 21-(乙酰氧基)-17-羟基普利4-ENE-3,20-二酮; 21-乙酰氧基-17α-羟基孕甾-4-烯-3,20-二酮; 17Α-羟基-11-脱氧皮质酮 21-乙酸酯; 2-((8R,9S,10R,13S,14S,17R)-17-羟基-10,13-二甲基-3-氧代-2,3,6,7,8,9,10,11,12,13,14,15,16,17-十四氢-1H-环戊[a]菲-17-基)-2-氧代乙酸乙酯; 羟基黄体酮21-醋酸酯; 氢化可的松杂质11(氢化可的松杂质K); 孕甾-4-烯-17ALPHA,21-二醇-3,20-二酮-21-醋酸酯; 克拉特龙中间体12
• 英文别名: 17α-Hydroxy-21-acetoxypregna-4-ene-3,20-dione; Einecs -4; 17α-Hydroxy-11-deoxycorticosterone-21-acetate; Hydrocortisone Impurity K; 17-ALPHA-HYDROXYCORTEXONE 21-ACETATE; 17Alpha-Hydroxyprogesterone 21-acetate [RSA]; 17a-Hydroxy Progesterone-21-Acetate; 21-acetoxy-17-hydroxy-pregn-4-ene-3,20-dione; 21-Acetoxy-17-hydroxy-pregn-4-en-3,20-dion; Cortexolone 21-acetate; 11-DEOXY-17-HYDROCORTICOSTERONE; 17a-Hydroxy Progesterone-21-Acetate(RSA); 11-DEOXYCORTISOL 21-ACETATE; ACETIC ACID 2-((8R,9S,10R,13S,14S,17R)-17-HYDROXY-10,13-DIMETHYL-3-OXO-2,3,6,7,8,9,10,11,12,13,14,15,16,17-TETRADECAHYDRO-1H-CYCLOPENTA[A]PHENANTHREN-17-YL)-2-OXO-ETHYL ESTER; SSUBSTANCES21-ACETATE; 21-Acetoxy-17α-hydroxypregna-4-ene-3,20-dione; 17alpha-Hydroxyprogesterone-21-acetate; 17-Hydroxy-21-acetoxy-pregnen-(4)-dion-(3.20); Reichstein substance S 21-acetate; 4-PREGNEN-17ALPHA,21-DIOL-3,20-DIONE 21-ACETATE; 17α,21-Dihydroxy-4-pregnene-3,20-dione 21-acetate; 4-PREGNEN-17,21-DIOL-3,20-DIONE 21-ACETATE; 3,20-Dioxopregn-4-ene-17,21-diol 21-acetate; 17a-Hydroxy-11-deoxycorticosterone-21-acetate; 4-PREGNENE-17-ALPHA,21-DIOL-3,20-DIONE 21-ACETATE; 21-Acetyloxy-17-hydroxypregn-4-ene-3,20-dione; 17α-Hydroxycortexone 21-acetate; Cortodoxon 21-acetate; 17a-Hydroxy-11-desoxycorticosterone acetate; Hydrocortisone Impurity 11（Hydrocortisone Impurity K）; 4-Pregnene-17α,21-diol-3,20-dione 21-acetate; 17-alpha,21-dihydroxypregn-4-ene-3,20-dione 21-acetate; 11-deoxycortisol 21-acetate; 17-Hydroxy-21-acetoxyprogesterone; Pregn-4-ene-3,20-dione, 21-(acetyloxy)-17-hydroxy; 2-((8R,9S,10R,13S,14S,17R)-17-hydroxy-10,13-dimethyl-3-oxo-2,3,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl)-2-oxoacetate ethyl ester; REICHSTEIN'S SUBSTANCE S 21-ACETATE; TIANFUCHEM-High purity REICHSTEIN'S SUBSTANCE S 21-ACETATE factory price; Einecs 211-369-4; Hydrocortisone Impurity K (Reichsteins Substance S-21-Acetate); 17-Hydroxy-3,20-dioxopregn-4-en-21-yl acetate; REICHSTEIN'S COMPOUND ''S'' ACETATE; NSC81196; 21-Acetoxy-17a-hydroxyprogesterone; Pregn-4-ene-17,21-diol-3,20-dione21-acetate; 17α-Hydroxyprogesterone Acetate-21-acetate; 17α,21-Dihydroxyprogesterone 21-acetate; CORTEXOLONE ACETATE; cortexolone 21-acetate; 11-Deoxy-17-hydrocorticosterone 21-acetate; Reichsteins substance S acetate; Hydrocortisone IMP K; 17-Hydroxy-3,20-dioxopregn-4-en-21-yl Acetate (Reichstein's Substance S 21-Acetate); 2-((8R,9S,10R,13S,14S,17R)-17-hydroxy-10,13-dimethyl-3-oxo-2,3,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl)-2-oxoethyl acetate; 11-deoxycortisone acetate; 17,21-Dihydroxypregn-4-ene-3,20-dione21-acetate; RSA,REICHSTEIN'S SUBSTANCE S 21-ACETATE; 4-HYDROXY CHOLESTEROL-D7 4-ACETATE（RSA）

物化性质

• 密度: 1.2g/cm3
• 沸点: 537.9ºC at 760 mmHg
• 熔点: 233-235ºC
• 分子式: C₂₃H₃₂O₅
• 分子量: 388.49700
• 闪点: 181.8ºC
• 精确质量: 388.22500
• PSA: 80.67000
• LogP: 3.38160
• 折射率: 1.558
• 储存条件: 室温，干燥
• 水溶解性: Insuluble (8.5E-3 g/L) (25 ºC)

合成路线

上下游产品

上游产品  9
108-22-5 152-58-9 19357-45-0 63973-94-4
20380-17-0 108-24-7 127-08-2 57273-80-0
481-29-8
下游产品  6
1807-15-4 54201-62-6 63-05-8 312-99-2
152-58-9 566-12-1

制备

可用薯蓣皂素经开环、酰化、氧化、水解、环氧化、氧化、（HBr）加成（引入16-位溴）、催化氢化（脱溴）、21-位碘化、（21-位碘以乙酰氧基）置换等步反应制得