18341-31-6

• 常用中文名：N-甲基-N-(2-丙炔)乙酰胺
• 常用英文名：N-methyl-N-prop-2-ynyl-acetamide
• CAS号：18341-31-6
• 分子式：C₆H₉NO
• 分子量：111.14200
• 发布时间：2018-06-26 15:11:23
• 更新时间：2024-02-04 20:12:33

名称

• 中文名: N-甲基-N-(2-丙炔)乙酰胺
• 英文名: N-methyl-N-prop-2-ynylacetamide
• 英文别名: N-methyl-N-propargylacetamide; N-methyl-N-prop-2-ynyl-acetamide; N-methyl-N-2-propyn-1-ylacetamide

物化性质

• 密度: 0.96g/cm3
• 沸点: 173.5ºC at 760 mmHg
• 分子式: C₆H₉NO
• 分子量: 111.14200
• 闪点: 66.2ºC
• 精确质量: 111.06800
• PSA: 20.31000
• LogP: 0.09790
• 蒸汽压: 1.26mmHg at 25°C
• 折射率: 1.455

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : AC6341000 CHEMICAL NAME : Acetamide, N-methyl-N-(2-propynyl)- CAS REGISTRY NUMBER : 18341-31-6 LAST UPDATED : 199612 DATA ITEMS CITED : 1 MOLECULAR FORMULA : C6-H9-N-O MOLECULAR WEIGHT : 111.16 WISWESSER LINE NOTATION : 1VN1&2UU1 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 42 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : CSLNX* U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. (Aberdeen Proving Ground, MD 21010) Volume(issue)/page/year: NX#09763

合成路线

851435-31-9 108-24-7 ~22% 18341-31-6

文献：ASTRAZENECA AB; ASTRAZENECA UK LIMITED Patent: WO2005/40159 A1, 2005 ; Location in patent: Page/Page column 214-215 ; WO 2005/040159 A1

35161-71-8 108-24-7 ~64% 18341-31-6

文献：Bradbury, Barton J.; Baumgold, Jesse; Paek, Robert; Kammula, Udai; Zimmet, Jeff; Jacobson, Kenneth A. Journal of Medicinal Chemistry, 1991 , vol. 34, # 3 p. 1073 - 1079

35161-71-8 ~% 18341-31-6

文献：American Cyanamid Company Patent: US4937235 A1, 1990 ;

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