14686-61-4

• 常用中文名：Formamide,N-methyl-N-[(7S)-5,6,7,9-tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo[a]heptalen-7-yl]-
• 常用英文名：Formamide,N-methyl-N-[(7S)-5,6,7,9-tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo[a]heptalen-7-yl]-
• CAS号：14686-61-4
• 分子式：C₂₂H₂₅NO₆
• 分子量：399.43700
• 发布时间：2017-08-17 15:20:10
• 更新时间：2024-04-04 05:17:45

名称

• 英文名: N-methyl-N-[(7S)-1,2,3,10-tetramethoxy-9-oxo-6,7-dihydro-5H-benzo[a]heptalen-7-yl]formamide
• 英文别名: N-Methyl-N-((S)-1,2,3,10-tetramethoxy-9-oxo-5,6,7,9-tetrahydro-benzo[a]heptalen-7-yl)-formamid; Formamide,N-methyl-N-(5,6,7,9-tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo(a)heptalen-7-yl); (-)-N-formyldemecolcine; N-methyl-N-((S)-1,2,3,10-tetramethoxy-9-oxo-5,6,7,9-tetrahydro-benzo[a]heptalen-7-yl)-formamide; COLCHICINE,N-DEACETYL-N-FORMYL-N-METHYL; N-Formyldemeocolcine

物化性质

• 密度: 1.25g/cm3
• 沸点: 705.1ºC at 760 mmHg
• 分子式: C₂₂H₂₅NO₆
• 分子量: 399.43700
• 闪点: 380.2ºC
• 精确质量: 399.16800
• PSA: 74.30000
• LogP: 3.45960
• 蒸汽压: 9.98E-20mmHg at 25°C
• 折射率: 1.59

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : GH0795000 CHEMICAL NAME : Colchicine, N-deacetyl-N-formyl-N-methyl- CAS REGISTRY NUMBER : 14686-61-4 BEILSTEIN REFERENCE NO. : 3179104 LAST UPDATED : 199612 DATA ITEMS CITED : 1 MOLECULAR FORMULA : C22-H25-N-O6 MOLECULAR WEIGHT : 399.48 WISWESSER LINE NOTATION : L B677 MV&T&J CO1 DO1 EO1 JN1&VH NO1 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intramuscular SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 72 mg/kg TOXIC EFFECTS : Nutritional and Gross Metabolic - weight loss or decreased weight gain REFERENCE : JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 24,257,1981

合成路线

477-30-5 109-94-4 ~78% 14686-61-4

文献：Dumont; Brossi; Silverton Journal of Organic Chemistry, 1986 , vol. 51, # 13 p. 2515 - 2521

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