54340-58-8

• 常用中文名：美普他酚
• 常用英文名：Meptazinol
• CAS号：54340-58-8
• 分子式：C₁₅H₂₃NO
• 分子量：233.349
• 相关类别： 原料药 解热镇痛药 镇痛药
• 发布时间：2018-03-27 08:00:00
• 更新时间：2024-01-06 12:31:59

名称

• 中文名: 美普他酚
• 英文名: 3-(3-ethyl-1-methylazepan-3-yl)phenol
• 中文别名: 美他西诺; 3-(3-乙基六氢-1-甲基-1H-氮杂卓基-3-基)苯酚
• 英文别名: Meptazinolum [INN-Latin]; Meptazinol [INN:BAN]; 3-(3-ethyl-1-methyl-1H-hexahydroazepin-3-yl)phenol; Phenol,3-(3-ethylhexahydro-1-methyl-1H-azepin-3-yl); Meptazinol; 3-(3-ethyl-1-methyl-azepan-3-yl)-phenol; 3-(3-Ethylhexahydro-1-methyl-1H-azepin-3-yl)phenol; EINECS 259-109-9; 3-(3-Ethyl-1-methylazepan-3-yl)phenol; (±)-3-(3-ethyl-1-methylhexahydro-1H-azepin-3-yl)phenol; 1-Methyl-3-ethyl-3-(m-hydroxyphenyl)hexahydro-1H-azepine; Phenol, 3-(3-ethylhexahydro-1-methyl-1H-azepin-3-yl)-; Meptid; 3-(3-Ethyl-1-methyl-3-azepanyl)phenol

物化性质

• 密度: 1.0±0.1 g/cm3
• 沸点: 354.8±35.0 °C at 760 mmHg
• 熔点: 127-133ºC
• 分子式: C₁₅H₂₃NO
• 分子量: 233.349
• 闪点: 160.6±24.6 °C
• 精确质量: 233.177963
• PSA: 23.47000
• LogP: 3.70
• 蒸汽压: 0.0±0.8 mmHg at 25°C
• 折射率: 1.524

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : SL4220000 CHEMICAL NAME : Phenol, 3-(3-ethylhexahydro-1-methyl-1H-azepin-3-yl)- CAS REGISTRY NUMBER : 54340-58-8 BEILSTEIN REFERENCE NO. : 1462600 LAST UPDATED : 199612 DATA ITEMS CITED : 1 MOLECULAR FORMULA : C15-H23-N-O MOLECULAR WEIGHT : 233.39 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Human - woman DOSE/DURATION : 200 mg/kg TOXIC EFFECTS : Lungs, Thorax, or Respiration - other changes REFERENCE : HUTODJ Human Toxicology. (Macmillan Press Ltd., Houndmills, Basingstoke, Hants., RG 21 2XS, UK) V.1- 1981- Volume(issue)/page/year: 6,331,1987

安全

• 海关编码: 2933990090

合成路线

59263-76-2 ~98% 54340-58-8

文献：Shire Pharmaceuticals, Inc. Patent: US2011/190267 A1, 2011 ; Location in patent: Page/Page column 46-47 ;

71556-74-6 ~92% 54340-58-8

文献：Bradley; Cavalla; Edington; et al. European Journal of Medicinal Chemistry, 1980 , vol. 15, # 4 p. 375 - 385

105-60-2 ~% 54340-58-8

文献：European Journal of Medicinal Chemistry, , vol. 15, # 4 p. 375 - 385

2556-73-2 ~% 54340-58-8

文献：European Journal of Medicinal Chemistry, , vol. 15, # 4 p. 375 - 385

71556-70-2 ~% 54340-58-8

文献：European Journal of Medicinal Chemistry, , vol. 15, # 4 p. 375 - 385

71592-44-4 ~% 54340-58-8

文献：European Journal of Medicinal Chemistry, , vol. 15, # 4 p. 375 - 385

上下游产品

上游产品  6
59263-76-2 71556-74-6 105-60-2 2556-73-2
71556-70-2 71592-44-4
下游产品  0

海关

海关编码	2933990090
中文概述	2933990090. 其他仅含氮杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
申报要素	品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期
Summary	2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%