7336-44-9

• 常用中文名：Demecolcine, N-methyl-
• 常用英文名：Demecolcine, N-methyl-
• CAS号：7336-44-9
• 分子式：C₂₂H₂₇NO₅
• 分子量：385.45300
• 发布时间：2017-05-14 12:31:11
• 更新时间：2024-01-09 19:16:50

名称

• 英文名: (7S)-7-(dimethylamino)-1,2,3,10-tetramethoxy-6,7-dihydro-5H-benzo[a]heptalen-9-one
• 英文别名: N,N-dimethyldeacetylcolchicine; N-Methyldemecolcine; N-Deacetyl-N,N-dimethylcolchicine; Demecolcine,N-methyl; N,N-Dimethyl-desacetyl-colchicin; N-Methyl-demecolcin; Methylademecolcine,N; N-methyldemocolcine; COLCHICINE,N-DEACETYL-N,N-DIMETHYL; N-Methylcolchamine

物化性质

• 密度: 1.2g/cm3
• 沸点: 619.7ºC at 760 mmHg
• 分子式: C₂₂H₂₇NO₅
• 分子量: 385.45300
• 闪点: 328.6ºC
• 精确质量: 385.18900
• PSA: 57.23000
• LogP: 3.29710
• 折射率: 1.581

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : GH0792000 CHEMICAL NAME : Colchicine, N-deacetyl-N,N-dimethyl- CAS REGISTRY NUMBER : 7336-44-9 LAST UPDATED : 198706 DATA ITEMS CITED : 4 MOLECULAR FORMULA : C22-H27-N-O5 MOLECULAR WEIGHT : 385.50 WISWESSER LINE NOTATION : L B677 MV&T&J CO1 DO1 EO1 JN1&1 NO1 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 27 mg/kg TOXIC EFFECTS : Behavioral - somnolence (general depressed activity) Behavioral - muscle weakness Gastrointestinal - hypermotility, diarrhea REFERENCE : PHTXA6 Pharmacology and Toxicology. English translation of FATOAO. (New York, NY) V.20-22, 1957-59. Discontinued. Volume(issue)/page/year: 20,284,1957 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 24 mg/kg TOXIC EFFECTS : Tumorigenic - active as anti-cancer agent REFERENCE : JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 24,636,1981 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 45 mg/kg TOXIC EFFECTS : Behavioral - somnolence (general depressed activity) Behavioral - muscle weakness Gastrointestinal - hypermotility, diarrhea REFERENCE : PHTXA6 Pharmacology and Toxicology. English translation of FATOAO. (New York, NY) V.20-22, 1957-59. Discontinued. Volume(issue)/page/year: 20,284,1957 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intramuscular SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 200 mg/kg TOXIC EFFECTS : Nutritional and Gross Metabolic - weight loss or decreased weight gain REFERENCE : JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 24,257,1981

合成路线

477-30-5 74-88-4 ~% 7336-44-9

文献：Kiselew; Men'schikow Doklady Akademii Nauk SSSR, 1953 , vol. 88, p. 825 Chem.Abstr., 1954 , p. 3952 Show Details Santavy Collection of Czechoslovak Chemical Communications, 1951 , vol. 16/17, p. 676,683 Show Details Uffer et al. Helvetica Chimica Acta, 1954 , vol. 37, p. 18,29

50-00-0 64-18-6 477-30-5 ~% 7336-44-9

文献：Kiselew; Men'schikow Doklady Akademii Nauk SSSR, 1953 , vol. 88, p. 825 Chem.Abstr., 1954 , p. 3952 Show Details Ueno Yakugaku Zasshi, 1953 , vol. 73, p. 1232,1233 Proceedings of the Japan Academy, 1953 , vol. 29, p. 266,269

50-00-0 64-18-6 3476-50-4 ~% 7336-44-9

文献：Kiselew Doklady Akademii Nauk SSSR, 1954 , vol. 96, p. 527 Chem.Abstr., 1955 , p. 9005

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