478-60-4

• 常用中文名：柠檬霉素
• 常用英文名：Citromycetin
• CAS号：478-60-4
• 分子式：C₁₄H₁₀O₇
• 分子量：290.22500
• 相关类别： 研究领域 其他
• 发布时间：2016-04-14 18:25:08
• 更新时间：2024-01-13 19:37:06
• 桔霉素是一种芳香聚酮化合物,来自澳大利亚海洋和陆地青霉[1]。

名称

• 中文名: 柠檬霉素
• 英文名: 8,9-dihydroxy-2-methyl-4-oxo-5H-pyrano[3,2-c]chromene-10-carboxylic acid
• 英文别名: Citromycetin; 4H,5H-Pyrano(3,2-c)(1)benzopyran-10-carboxylic acid,8,9-dihydroxy-2-methyl-4-oxo; Frequentic acid; 8,9-dihydroxy-2-methyl-4-oxo-4H,5H-pyrano[3,2-c]chromene-10-carboxylic acid; 8,9-Dihydroxy-2-methyl-4-oxo-4H,5H-pyrano[3,2-c]chromen-10-carbonsaeure

物化性质

• 分子式: C₁₄H₁₀O₇
• 分子量: 290.22500
• 精确质量: 290.04300
• PSA: 117.20000
• LogP: 1.61700

生物活性

• 描述: 桔霉素是一种芳香聚酮化合物,来自澳大利亚海洋和陆地青霉[1]。
• 相关类别:
  研究领域 >> 其他
  信号通路 >> 其他 >> 其他
• 参考文献:

  [1]. Capon RJ, et al. Citromycetins and bilains A-C: new aromatic polyketides and diketopiperazines from Australian marine-derived and terrestrial Penicillium spp. J Nat Prod. 2007;70(11):1746-1752.

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : UQ0334000 CHEMICAL NAME : 4H,5H-Pyrano(3,2-c)(1)benzopyran-10-carboxylic acid, 8,9-dihydroxy-2-methyl-4-oxo- CAS REGISTRY NUMBER : 478-60-4 BEILSTEIN REFERENCE NO. : 0330020 LAST UPDATED : 199612 DATA ITEMS CITED : 2 MOLECULAR FORMULA : C14-H10-O7 MOLECULAR WEIGHT : 290.24 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 750 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : 85GDA2 "CRC Handbook of Antibiotic Compounds," Vols.1- , Berdy, J., Boca Raton, FL, CRC Press, 1980- Volume(issue)/page/year: 5,406,1981 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 800 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : 85GDA2 "CRC Handbook of Antibiotic Compounds," Vols.1- , Berdy, J., Boca Raton, FL, CRC Press, 1980- Volume(issue)/page/year: 5,406,1981

合成路线

101905-34-4 ~68% 478-60-4

文献：Yamauchi, Masashige; Katayama, Sadamu; Watanabe, Toshio Journal of the Chemical Society, Chemical Communications, 1985 , # 21 p. 1483 - 1484

101905-32-2 ~% 478-60-4

文献：Yamauchi, Masashige; Katayama, Sadamu; Watanabe, Toshio Journal of the Chemical Society, Chemical Communications, 1985 , # 21 p. 1483 - 1484

101905-33-3 ~% 478-60-4

文献：Yamauchi, Masashige; Katayama, Sadamu; Watanabe, Toshio Journal of the Chemical Society, Chemical Communications, 1985 , # 21 p. 1483 - 1484

101905-31-1 ~% 478-60-4

文献：Yamauchi, Masashige; Katayama, Sadamu; Watanabe, Toshio Journal of the Chemical Society, Chemical Communications, 1985 , # 21 p. 1483 - 1484

101905-30-0 ~% 478-60-4

文献：Yamauchi, Masashige; Katayama, Sadamu; Watanabe, Toshio Journal of the Chemical Society, Chemical Communications, 1985 , # 21 p. 1483 - 1484

101923-12-0 ~% 478-60-4

文献：Yamauchi, Masashige; Katayama, Sadamu; Watanabe, Toshio Journal of the Chemical Society, Chemical Communications, 1985 , # 21 p. 1483 - 1484

95730-77-1 ~% 478-60-4

文献：Yamauchi, Masashige; Katayama, Sadamu; Watanabe, Toshio Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1987 , p. 395 - 398

上下游产品

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101905-32-2
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37209-30-6