64-99-3

• 常用中文名：Etimizol
• 常用英文名：Etimizol
• CAS号：64-99-3
• 分子式：C₉H₁₄N₄O₂
• 分子量：210.23300
• 相关类别： 信号通路 细胞周期/DNA损伤 PARP
• 发布时间：2017-08-30 13:34:43
• 更新时间：2024-01-07 17:41:53
• Etimizol(Ethymisole; Antiffine; Ethylnorantifein)可有效地作用于缺氧造成的失忆症。

名称

• 中文名: Etimizol
• 英文名: 1-ethyl-4-N,5-N-dimethylimidazole-4,5-dicarboxamide
• 英文别名: aethimizolum; Ethimizol; Ethymisol; 1-ethyl-1H-imidazole-4,5-dicarboxylic acid bis-methylamide; Ethymysol; 1 ethyl 4,5 bis(methylcarbamoyl)imidazole; Ethylnorantefein; Etimyzol; 1-ethyl-4,5-di(N-methylcarbamoyl)-imidazole; Antiffine; Ethimizole; Ethymisole; 1-ethylimidazole-4,5-dicarboxylic acid di(methylamide); Ethymazol; ETIMIZOL

物化性质

• 密度: 1.26g/cm3
• 沸点: 563.4ºC at 760 mmHg
• 分子式: C₉H₁₄N₄O₂
• 分子量: 210.23300
• 闪点: 294.5ºC
• 精确质量: 210.11200
• PSA: 83.00000
• LogP: 0.77180
• 折射率: 1.586
• 储存条件: -20°C

生物活性

• 描述: Etimizol(Ethymisole; Antiffine; Ethylnorantifein)可有效地作用于缺氧造成的失忆症。
• 相关类别:
  信号通路 >> 其他 >> 其他
  天然产物 >> 生物碱
  研究领域 >> 神经疾病
• 参考文献:

  [1]. Borisova GIu. Effect of etimizol on instrumental learning in rats. Biull Eksp Biol Med. 1985 Jun;99(6):705-6.

  [2]. Trnovec T, et al. Etimizol absorption from the small intestine in dogs: the dependence on dosage. Biull Eksp Biol Med. 1986 Dec;102(12):729-30.

  [3]. Vislobokov AI, et al. Elektrophysiological parameters of mollusk neurons under the influence of etimizol. Fiziol Zh SSSR Im I M Sechenova. 1975 Jun;61(6):917-24.

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : NI4750500 CHEMICAL NAME : 1H-Imidazole-4,5-dicarboxamide, 1-ethyl-N,N'-dimethyl- CAS REGISTRY NUMBER : 64-99-3 BEILSTEIN REFERENCE NO. : 0525707 LAST UPDATED : 199612 DATA ITEMS CITED : 2 MOLECULAR FORMULA : C9-H14-N4-O2 MOLECULAR WEIGHT : 210.27 WISWESSER LINE NOTATION : T5N CNJ A2 DVM1 EVM1 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 220 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : PCJOAU Pharmaceutical Chemistry Journal (English Translation). Translation of KHFZAN. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) No.1- 1967- Volume(issue)/page/year: 20,99,1986 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 160 mg/kg TOXIC EFFECTS : Behavioral - somnolence (general depressed activity) REFERENCE : FATOAO Farmakologiya i Toksikologiya (Moscow). For English translation, see PHTXA6 and RPTOAN. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.2- 1939- Volume(issue)/page/year: 42,221,1979

安全

• 海关编码: 2934999090

海关

海关编码	2934999090
中文概述	2934999090. 其他杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
申报要素	品名, 成分含量, 用途
Summary	2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%