620611-28-1

• 常用中文名：4-氟-4-((1,3-二氧代异吲哚啉-2-基)甲基)哌啶-1-羧酸叔丁酯
• 常用英文名：tert-butyl 4-[(1,3-dioxoisoindol-2-yl)methyl]-4-fluoropiperidine-1-carboxylate
• CAS号：620611-28-1
• 分子式：C₁₉H₂₃FN₂O₄
• 分子量：362.39500
• 发布时间：2018-06-20 10:36:23
• 更新时间：2024-02-26 16:57:27

名称

• 中文名: 4-氟-4-((1,3-二氧代异吲哚啉-2-基)甲基)哌啶-1-羧酸叔丁酯
• 英文名: tert-butyl 4-[(1,3-dioxoisoindol-2-yl)methyl]-4-fluoropiperidine-1-carboxylate
• 英文别名: TERT-BUTYL 4-FLUORO-4-((1,3-DIOXOISOINDOLIN-2-YL)METHYL)PIPERIDINE-1-CARBOXYLATE; 4-[(1,3-dioxo-2-isoindolyl)methyl]-4-fluoro-1-piperidinecarboxylic acid tert-butyl ester; tert-butyl 4-((1,3-dioxoisoindolin-2-yl)methyl)-4-fluoropiperidine-1-carboxylate; tert-butyl 4-[[1,3-bis(oxidanylidene)isoindol-2-yl]methyl]-4-fluoranyl-piperidine-1-carboxylate

物化性质

• 分子式: C₁₉H₂₃FN₂O₄
• 分子量: 362.39500
• 精确质量: 362.16400
• PSA: 66.92000
• LogP: 2.89760

合成路线

918431-90-0 1074-82-4 ~% 620611-28-1

文献：Shipe, William D.; Barrow, James C.; Yang, Zhi-Qiang; Lindsley, Craig W.; Yang, F. Vivien; Schlegel, Kelly-Ann S.; Shu, Youheng; Rittle, Kenneth E.; Bock, Mark G.; Hartman, George D.; Tang, Cuyue; Ballard, Jeanine E.; Kuo, Yuhsin; Adarayan, Emily D.; Prueksaritanont, Thomayant; Zrada, Matthew M.; Uebele, Victor N.; Nuss, Cindy E.; Connolly, Thomas M.; Doran, Scott M.; Fox, Steven V.; Kraus, Richard L.; Marino, Michael J.; Graufelds, Valerie Kuzmick; Vargas, Hugo M.; Bunting, Patricia B.; Hasbun-Manning, Martha; Evans, Rose M.; Koblan, Kenneth S.; Renger, John J. Journal of Medicinal Chemistry, 2008 , vol. 51, # 13 p. 3692 - 3695

136918-14-4 ~% 620611-28-1

文献：TEIJIN LIMITED Patent: EP1505067 A1, 2005 ; Location in patent: Page/Page column 369 ; EP 1505067 A1

147804-30-6 ~% 620611-28-1

文献：AC Immune, S.A. Patent: US2011/256064 A1, 2011 ;

614730-97-1 ~% 620611-28-1

文献：AC Immune, S.A. Patent: US2011/256064 A1, 2011 ;