1421-28-9

• 常用中文名：Morphinan-3,6-diol,4,5-epoxy-17-methyl-, hydrochloride, (5a,6a)- (9CI)
• 常用英文名：Morphinan-3,6-diol,4,5-epoxy-17-methyl-, hydrochloride, (5a,6a)- (9CI)
• CAS号：1421-28-9
• 分子式：C₁₇H₂₂ClNO₃
• 分子量：323.81400
• 发布时间：2018-06-13 21:00:07
• 更新时间：2024-04-11 11:37:45

名称

• 英文名: Morphinan-3,6-diol,4,5-epoxy-17-methyl-, hydrochloride, (5a,6a)- (9CI)
• 英文别名: Dihydromorphine hydrochloride; Morphine,dihydro-,hydrochloride; morphine hydrochloride

物化性质

• 沸点: 475.4ºC at 760mmHg
• 分子式: C₁₇H₂₂ClNO₃
• 分子量: 323.81400
• 闪点: 241.3ºC
• 精确质量: 323.12900
• PSA: 52.93000
• LogP: 2.16200
• 蒸汽压: 7.65E-10mmHg at 25°C

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : QD4200000 CHEMICAL NAME : Morphine, dihydro-, hydrochloride CAS REGISTRY NUMBER : 1421-28-9 LAST UPDATED : 199512 DATA ITEMS CITED : 4 MOLECULAR FORMULA : C17-H21-N-O3.Cl-H MOLECULAR WEIGHT : 323.85 WISWESSER LINE NOTATION : T B6566 B6/CO 4ABBC R BX HO PN GHT&&TTJ EQ JQ P1 &GH HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 149 mg/kg TOXIC EFFECTS : Behavioral - excitement Lungs, Thorax, or Respiration - other changes REFERENCE : JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 52,468,1934 TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rabbit DOSE/DURATION : 800 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : HBAMAK "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." (Leipzig, Ger. Dem. Rep.) Volume(issue)/page/year: 4,1289,1935 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - rabbit DOSE/DURATION : 186 mg/kg TOXIC EFFECTS : Behavioral - convulsions or effect on seizure threshold REFERENCE : JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 66,182,1939 TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - guinea pig DOSE/DURATION : 500 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : HBAMAK "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." (Leipzig, Ger. Dem. Rep.) Volume(issue)/page/year: 4,1289,1935

合成路线

52-26-6 ~97% 1421-28-9

文献：Synthesis (Germany), , vol. 44, # 18 p. 2840 - 2842

57-27-2 ~% 1421-28-9

文献：Pharmaceutical Sciences, , vol. 2, # 6 p. 299 - 303

上下游产品

上游产品  2
52-26-6 57-27-2
下游产品  1
71-68-1