32634-95-0

• 常用中文名：6-亚甲基孕甾-4-烯-17Alpha-醇-3,20-二酮-17-醋酸酯
• 常用英文名：6-Methylene Progesterone Acetate
• CAS号：32634-95-0
• 分子式：C₂₄H₃₂O₄
• 分子量：384.50800
• 发布时间：2018-10-06 09:44:19
• 更新时间：2025-08-20 11:21:08
• 甲地孕酮的中间体。

名称

• 中文名: 6-亚甲基孕甾-4-烯-17Alpha-醇-3,20-二酮-17-醋酸酯
• 英文名: [(8R,9S,10R,13S,14S,17R)-17-acetyl-10,13-dimethyl-6-methylidene-3-oxo-1,2,7,8,9,11,12,14,15,16-decahydrocyclopenta[a]phenanthren-17-yl] acetate
• 中文别名: 醋酸甲羟孕酮杂质E; 安宫黄体酮次甲基; 17Α- 乙酰氧基 -6- 亚甲基孕甾 -4- 烯 -3,20- 二酮; 次甲基; 醋酸次甲基; 醋酸甲羟孕酮杂质E 标准品; 醋酸甲地孕酮杂质D; 醋酸甲地孕酮相关化合物D; 醋酸甲孕酮杂质E; 17alpha-乙酰氧基-6-亚甲基孕甾-4-烯-3,20-二酮; 醋酸甲羟黄体酮杂质E(醋酸甲地黄体酮杂质D); 7ALPHA-乙酰氧基-6-亚甲基孕甾-4-烯-3,20-二酮; 醋酸甲地孕酮; 6-甲基醋酸孕酮; 醋酸甲羟孕酮杂质E(甲羟孕酮杂质D); (8R,9S,10R,13S,14S,17R)-17-乙酰基-10,13-二甲基-6-亚甲基-3-氧代-2,3,6,7,8,9,10,11,12,13,14,15,16,17-十四氢-1H-环戊基[A]菲-17-乙酸酯 (甲羟孕酮杂质); 17ALPHA-乙酰氧基-6-亚甲基孕甾-4-烯-3,20-二酮; 6-亚甲基醋酸孕酮; 6-次甲基-17 Α-羟基黄体酮醋酸酯; 醋酸甲地孕酮杂质D/BP); 17-(乙酰氧基)-6-亚甲基孕甾-4-烯-3,20-二酮; 醋酸甲羟孕酮杂质E(醋酸甲地孕酮杂质D); 6-亚甲基孕甾-4-烯-17Α-醇-3,20-二酮-17-醋酸酯; 次甲基黄体酮醋酸酯; 甲羟孕酮杂质E; 6-亚甲基孕酮醋酸酯; 6-亚甲基羟孕酮乙酸酯
• 英文别名: 6-Methylenehydroxyprogesterone Acetate; 6-Methylene-17-alpha-hydroxyprogesterone acetate; 6-methylene-17α-hydroxyprogesterone acetate; (17α-hydroxy-6-methylenregn-4-ene-3,20-dione; 6-Methlenrogesterone; 6,6'-DehydroMedroxyprogesterone Acetate; (8R,9S,10R,13S,14S,17R)-17-acetyl-10,13-dimethyl-6-methylene-3-oxo-2,3,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl acetate; Dehydromedroxyprogesterone acetate; 6-Methylene-17α-hydroxyprogesterone; 17-Acetyloxy-6-methylenrogn-4-ene-3,20-dione; EINECS 251-133-8; 6-Methylene-17a-hydroxyprogesterone acetate; Megestrol Acetate Impurity D / Medroxyprogesterone Impurity E; (8R,9S,10R,13S,14S,17R)-17-Acetyl-10,13-dimethyl-6-methylene-3-oxo-2,3,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl acetate (Medroxyprogesterone Acetate Impurity); 17-Hydroxy-6-Methylenrogesterone Acetate; Methine; 17alpha-Acetoxy-6-Methylenregn-4-ene-3; 6-Methylidene-3,20-dioxopregn-4-en-17-yl Acetate (6-Methylenehydroxyprogesterone Acetate); 17-Acetoxy-6-Methylenregn-4-ene-3,20-dione; Nsc; 6-Methylene-17Alpha-hydroxyprogesterone acetate; 17-(Acetyloxy)-6-methylenregn-4-ene-3,20-dione; Amuteromethyl; 6-Methylene-17-acetoxypregna-4-ene-3,20-dione; Medroxyprogesterone Acetate impurity E; 17alpha-Acetoxy-6-methylenregn-4-ene-3,20-dione; Medroxyprogesterone Impurity E; Megestrol acetate Impurity D; 17|A-Acetoxy-6-methyleneprogesterone; 17-Hydroxy-6-Methylenregn-4- ene-3,20-dione Acetate; 17alpha-Acetoxy-6-methylenepregn-4-ene-3,20-dione; 6-methylene-pregnan-4-ene-17 α-ol-3, 20-diketo-17-acetate; 6-methylene-17α-acetoxyprogesterone; 17α-Acetoxy-6-Methylenrogesterone; Megestrol Acetate Related Compound D; 17-Acetoxy-6-methylene-4-pregnene-3,20-dione; 17-hydroxy-6-methylenregn-4-ene-3,20-dione 17-acetate; Pregn-4-ene-3,20-dione, 17-(acetyloxy)-6-methylene; CAS NO.:32-0 6-METHYLENE-17A-HYDROXYPROGESTERONE ACETATE; Medroxyprogesterone Acetate Impurity E (Megestrol Acetate Impurity D); Megestrol Acetate Impurity 4(Megestrol Acetate Impurity D); 17α-Acetoxy-6-Methylenregn -4-ene-3,20-dione; 6-Methylidene-3,20-dioxopregn-4-en; Einecs -8; 6-Methylene-4-en-17 Α- Alcohol-3,20-dione-17-acetate

物化性质

• 密度: 1.14g/cm3
• 沸点: 507.6ºC at 760mmHg
• 熔点: 248-251 ºC (methanol )
• 分子式: C₂₄H₃₂O₄
• 分子量: 384.50800
• 闪点: 218.7ºC
• 精确质量: 384.23000
• PSA: 60.44000
• LogP: 4.57530
• 折射率: 1.546
• 水溶解性: Insuluble (3.8E-3 g/L) (25 ºC)

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制备

可用16,17α-环氧孕甾-4-烯-3,20-二酮（即环氧黄体酮）经（环氧基与溴化氢）加成、催化氢化（除16-位溴）、（3-位酮基、17α-位羟基）乙酰化（同时形成3-位、5-位双键）、水解（脱除3-位乙酰基，3-位酮基、4-位双烯复原），生成17α-乙酰氧基黄体酮（即17α-羟基孕甾-4-烯-3,20-二酮-17-醋酸酯），然后（3-位以原甲酸三乙酯）醚化、（6-位以二甲基甲酰胺）甲酰化并还原得到3-乙氧基-17α-羟基-6-羟基甲基孕甾-3,5-二烯-20-酮-17-醋酸酯，最后水解（3-位酮基、4-位双键复原，并形成6-位亚甲基）制得该品。