767340-03-4

• 常用中文名：(2Z)-4-氧代-4-[3-(三氟甲基)-5,6-二氢-[1,2,4]三唑并[4,3-a]吡嗪-7(8H)-基]-1-(2,4,5-三氟苯基)丁-2-烯-2-胺
• 常用英文名：(2Z)-4-Oxo-4-[3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazine-7(8H)-yl]-1-(2,4,5-trifluorophenyl)but-2-en-2-amine
• CAS号：767340-03-4
• 分子式：C₁₆H₁₃F₆N₅O
• 分子量：405.298
• 发布时间：2018-10-09 17:05:37
• 更新时间：2026-07-05 08:45:25
• 西他列汀中间体

名称

• 中文名: (2Z)-4-氧代-4-[3-(三氟甲基)-5,6-二氢-[1,2,4]三唑并[4,3-a]吡嗪-7(8H)-基]-1-(2,4,5-三氟苯基)丁-2-烯-2-胺
• 英文名: (Z)-3-amino-1-[3-(trifluoromethyl)-6,8-dihydro-5H-[1,2,4]triazolo[4,3-a]pyrazin-7-yl]-4-(2,4,5-trifluorophenyl)but-2-en-1-one
• 中文别名: 磷酸西格列汀杂质20; (2Z)-4-氧代-4-[3-(三氟甲基)-5,6-二氢-[1,2,4]三唑并[4,3-A]吡嗪-7(8H)-基]-1-(2,4,5-三氟苯基)-2-丁烯胺; 西他列汀杂质9; 西格列汀杂质M; (2Z)-4-氧代-4-[3-(三氟甲基)-5; 西他列汀烯胺杂质; 7(8H)-基]-1-(245-三氟苯基)丁-2-烯-2-胺; 西格杂质F; 西格列汀烯胺杂质; 7(8H)-基]-1-丁-2-烯-2-胺; 西他列汀杂质; (2Z)-4-氧代-4-[3-(三氟甲基)-5,6-二氢-[1,2,4]三唑并[4,3-a]吡嗪-7(8H)-基]-1-(2,4,5-三氟苯基)丁-2-烯-2-胺【】【规; 5-三氟苯基)丁-2-烯-2-胺; 西他列汀中间体3; 西他列汀杂质41; 化合物 (2Z)-4-OXO-4-[3-(TRIFLUOROMETHYL)-5,6-DIHYDRO[1,2,4]TRIAZOLO[4,3-A]PYRAZINE-7(8H)-YL]-1-(2,4,5-TRIFLUOROPHENYL)BUT-2-EN-2-AMINE; (2Z) -2-氨基- 4-氧-4-[3-(三氟甲基)-5,6-二氢[1,2,4]三唑[4,3-Α]吡嗪-7(8H)-基]-1-(2,4,5-三氟苯基)丁基-2-烯; 西格列汀杂质14; (2Z)-2-氨基-4-氧-4-[3-(三氟甲基)-5,6-二氢[1,2,4]三唑[4,3-Α]吡嗪-7(8H)-基]-1-(2,4,5-三氟苯基)丁基-2-烯(2-4); (2Z)-4-氧代-4-[3-(三氟甲基)-5,6-二氢-[1,2,4]三唑并[4,3-A]吡嗪-7(8H)-基]-1-(2,4,5-三氟苯基)丁-2-烯-2-胺(西格列汀杂质)
• 英文别名: 2-Buten-1-one, 3-amino-1-[5,6-dihydro-3-(trifluoromethyl)-1,2,4-triazolo[4,3-a]pyrazin-7(8H)-yl]-4-(2,4,5-trifluorophenyl)-, (2Z); (2Z)-4-{[tert-butyl(dimethyl)silyl]oxy}but-2-en-1-ol; (2Z)-4-oxo-4-[3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]-1-(2,4,5-trifluorophenyl)but-2-en-2-amine; (2Z)-4-Oxo-4-[3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo-[4,3-a]pyrazine-7(8H)-yl]-1-(2,4; 3-Amino-1-(3-trifluoroMethyl-5,6-dihydro-8H-[1,2,4]triazolo[4,3-a]pyrazin-7-yl)-4-(2,4,5-trifluoro-phenyl)-but-2-en-1-one; (2Z)-4-Oxo-4-[3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]-1-(2,4,5-trifluorophenyl)but-2-en-2-amine; 3-(1-Phenyl-ethylamino)-1-(3-trifluoromethyl-5,6-dihydro-8H-[1,2,4]triazolo[4,3-a]pyrazin- 7-yl)-4-(2,4,5,trifluoro-phenyl)-butan-1-one; T56 AN CNN GN&TJ BXFFF GV1UYZ1R BF DF EF; 3-Amino-1-(3-Trifluoromethyl)-5,6-Dihydro-8H-[1,2,4]Triazolo[4,3-A]Pyrazine-7-Yl-4-(2,4,5-Trifluorophenyl)But-2-En-2-Amine; Sitagliptin Enamine Imp; Sitagliptin Enamine; 2-Buten-1-ol,4-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-,(Z); (Z)-4-(tert-butyl-dimethyl-silanyloxy)-but-2-en-1-ol; (Z)-3-amino-1-(3-trifluoromethyl-5,6-dihydro-8H-[1,2,4]triazolo[4,3-a]pyrazin-7-yl)-4-(2,4,5-trifluorophenyl)but-2-en-1-one; 5-trifluorophenyl)but-2-en-2-amine; (Z)-3-amino-1-(3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]-pyrazyn-7(8H)-yl)-4-(2,4,5-trifluorophenyl)but-2-en-1-one; 3-a]pyrazine-7(8H)-yl]-1-(2; Sitagliptin Enamine ImpurityQ: What is Sitagliptin Enamine Impurity Q: What is the CAS Number of Sitagliptin Enamine Impurity Q: What is the storage condition of Sitagliptin Enamine Impurity; (2Z)-4-Oxo-4-[3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-α]pyrazin -7(8H)-yl]-1-(2,4,5-trifluorophenyl)but-2-en-2-amine; Sitagliptin Impurity 9; (Z)-3-amino-1-(3-(trifluoroMethyl) -5,6-dihydro-[1,2,4]triazolo[4,3-a] pyrazin-7(8H)-yl)-4-(2,4,5-trifluorophenyl)but-2-en-1-one; Oxo-4-[3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazine-7(8H)-yl]-1-(2,4,5-trifluorophenyl)but-2-en-2-amine; Sitagliptin impurity 12/Sitagliptin Enamine Impurity/(2Z)-4-Oxo-4-[3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]-1-(2,4,5-trifluorophenyl)but-2-en-2-amine; cis-4-(1,1,2,2-tetramethyl-1-silapropoxy)but-2-en-1-ol; (Z)-3-amino-1-(3-(trifluoromethyl); (2Z)-4-Oxo-4-[3-(trifluoromethyl)-5; (2Z)-4-Oxo-4-[3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]-1-(2,4,5-trifl; (2Z)-3-amino-1-[3-(trifluoroMethyl)-5H,6H,7H,8H-[1,2,4]triazolo[4,3-a]pyrazin-7-yl]-4-(2,4,5-trifluorophenyl)but-2-en-1-one; (2Z)-3-Amino-1-[5,6-dihydro-3-(trifluoromethyl)-1,2,4-triazolo[4,3-α]pyrazin-7(8H)-yl]-4-(2,4,5-trifluorophenyl)-2-buten-1-one; 7(8H); （2Z）-2-amine -4-oxo-4-[3-(trifluoromethyl)-5,6-dihydro][1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl] -1-(2,4,5-trifluorophenyl)but-2-en; (2Z)-3-Amino-1-[3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]-4-(2,4,5-trifluorophenyl)-2-buten-1-one; (2Z)-4-(tert-butyldimethylsilanyloxy)but-2-en-1-ol; (2Z)-4-Oxo-4-[3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin -7(8H)-yl]-1-(2,4,5-trif; (2Z)-4-Oxo-4-[3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazine-7(8H)-yl]-1-(2,4,5-trifluorophenyl)but-2-en-2-amine (Sitagliptin Impurity); cis-4-(tert-butyldimethylsilanyloxy)-but-2-en-1-ol; 2-Buten-1-ol,4-[[(1,1-dimethylethyl)dimethylsilyl]oxy]; (2Z)-3-Amino-1-[5,6-dihydro-3-(trifluoromethyl)-1,2,4-triazolo[4,3-a]pyrazin-7(8H)-yl]-4-(2,4,5-trifluorophenyl)-2-buten-1-one; (2Z)-4-oxo-4-[3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]; (2Z)-4-Oxo-4-[3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo-[4,3-a]pyrazine-7(8H)-yl]-1-(2,4,5-t; Sitagliptin-12; (2Z)-4-oxo-4-[3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]-1-(2,4,5-trifluorophenyl)butan-2-en-2-amine

物化性质

• 密度: 1.6±0.1 g/cm3
• 沸点: 555.1±60.0 °C at 760 mmHg
• 熔点: 178-180ºC
• 分子式: C₁₆H₁₃F₆N₅O
• 分子量: 405.298
• 闪点: 289.5±32.9 °C
• 精确质量: 405.102417
• PSA: 77.04000
• LogP: 1.29
• 蒸汽压: 0.0±1.5 mmHg at 25°C
• 折射率: 1.590
• 储存条件: Refrigerator

安全

• 海关编码: 2933990090

合成路线

764667-65-4 ~84% 767340-03-4

文献：Hansen, Karl B.; Hsiao, Yi; Xu, Feng; Rivera, Nelo; Clausen, Andrew; Kubryk, Michele; Krska, Shane; Rosner, Thorsten; Simmons, Bryon; Balsells, Jaume; Ikemoto, Nori; Sun, Yongkui; Spindler, Felix; Malan, Christophe; Grabowski, Edward J. J.; Armstrong III, Joseph D. Journal of the American Chemical Society, 2009 , vol. 131, # 25 p. 8798 - 8804

海关

海关编码	2933990090
中文概述	2933990090. 其他仅含氮杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
申报要素	品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期
Summary	2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%