57645-49-5

• 常用中文名：4-AMINO-5-CHLORO-2-METHOXY-N-PIPERIDIN-4-YL-BENZAMIDE
• 常用英文名：4-AMINO-5-CHLORO-2-METHOXY-N-PIPERIDIN-4-YL-BENZAMIDE
• CAS号：57645-49-5
• 分子式：C₁₃H₁₈ClN₃O₂
• 分子量：283.75400
• 发布时间：2017-05-27 09:57:24
• 更新时间：2024-01-19 14:50:59

名称

• 英文名: 4-amino-5-chloro-2-methoxy-N-piperidin-4-ylbenzamide
• 英文别名: 4-AMINO-5-CHLORO-2-METHOXY-N-PIPERIDIN-4-YL-BENZAMIDE; 4-amino-5-chloro-2-methoxy-N-4-piperidinyl-benzamide; 4-(4-amino-5-chloro-2-methoxy-benzoylamino)-piperidine-1-carboxylic acid; Desbenzylclebopride; N-<4'-Piperidyl>-2-methoxy-4-amino-5-chlorbenzamid; BENZAMIDE,4-AMINO-5-CHLORO-2-METHOXY-N-(4-PIPERIDYL); 4-Amino-5-chloro-2-methoxy-N-(4-piperidyl)benzamide; N-(piperid-4-yl)-2-methoxy-4-amino-5-chlorobenzamide

物化性质

• 密度: 1.29g/cm3
• 沸点: 440.9ºC at 760 mmHg
• 分子式: C₁₃H₁₈ClN₃O₂
• 分子量: 283.75400
• 闪点: 220.5ºC
• 精确质量: 283.10900
• PSA: 76.38000
• LogP: 2.71350
• 折射率: 1.596

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : CU9395000 CHEMICAL NAME : Benzamide, 4-amino-5-chloro-2-methoxy-N-(4-piperidyl)- CAS REGISTRY NUMBER : 57645-49-5 BEILSTEIN REFERENCE NO. : 0482803 LAST UPDATED : 199612 DATA ITEMS CITED : 4 MOLECULAR FORMULA : C13-H18-Cl-N3-O2 MOLECULAR WEIGHT : 283.79 WISWESSER LINE NOTATION : T6MTJ DMVR DZ CG FO1 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 2550 mg/kg TOXIC EFFECTS : Behavioral - changes in motor activity (specific assay) Lungs, Thorax, or Respiration - respiratory stimulation Lungs, Thorax, or Respiration - other changes REFERENCE : OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 25,865,1983 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 1750 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 25,865,1983 ** OTHER MULTIPLE DOSE TOXICITY DATA ** TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 8750 mg/kg/5W-C TOXIC EFFECTS : Behavioral - food intake (animal) Endocrine - other changes Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol) REFERENCE : OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 25,865,1983 ** REPRODUCTIVE DATA ** TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral DOSE : 3500 mg/kg SEX/DURATION : female 35 day(s) pre-mating TOXIC EFFECTS : Reproductive - Maternal Effects - uterus, cervix, vagina REFERENCE : OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 25,865,1983

合成路线

55905-53-8 ~% 2401-24-3 57645-49-5 71084-64-5 详细

文献：Hayasaka; Murata; Umemura Chemical and Pharmaceutical Bulletin, 1981 , vol. 29, # 5 p. 1478 - 1480

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