79770-24-4

• 常用中文名：碘曲仑
• 常用英文名：Iotrolan
• CAS号：79770-24-4
• 分子式：C₃₇H₄₈I₆N₆O₁₈
• 分子量：1626.23
• 相关类别： 原料药 诊断用药 影象检查用药
• 发布时间：2018-03-13 08:00:00
• 更新时间：2026-07-01 18:49:12
• Iotrolan 是一种传统的造影剂。Iotrolan 对 NP 细胞活力没有影响或诱导细胞凋亡。

名称

• 中文名: 碘曲仑
• 英文名: 2,4,6-triiodo-5-[methyl-[3-oxo-3-[2,4,6-triiodo-N-methyl-3,5-bis(1,3,4-trihydroxybutan-2-ylcarbamoyl)anilino]propanoyl]amino]-1-N,3-N-bis(1,3,4-trihydroxybutan-2-yl)benzene-1,3-dicarboxamide
• 中文别名: 药典对照品/碘曲仑/用于系统适用性试验/A1A; 碘特罗兰; 2,4,6-三碘-5-[甲基-[3-[甲基-[2,4,6-三碘-3,5-双(1,3,4-三羟基丁-2-基氨基甲酰基)苯基]氨基]-3-氧代丙酰]氨基]-N,N'-双(1,3,4-三羟基丁-2-基)苯-1,3-二甲酰胺; 碘曲仑/A1A; 碘曲仑/用于系统适用性试验/A1A; 碘曲仑用于系统适应性 标准品; 奥特罗兰; 碘曲仑 标准品
• 英文别名: 2,4,6-triiodo-5-[methyl-[3-[methyl-[2,4,6-triiodo-3,5-bis(1,3,4-trihydroxybutan-2-ylcbamoyl)phenyl]amino]-3-oxopropanoyl]amino]-n,n'-bis(1,3,4-trihydroxybutan-2-yl)benzene-1,3-dicboxamide; SHL 437AA; DL-3117; Iotrol; Iotrolan for system suitability CRS; 5,5'-(malonylbis(methylazanediyl))bis(2,4,6-triiodo-N1,N3-bis(1,3,4-trihydroxybutan-2-yl)isophthalamide); SH 437; Iotrovist; Iotrolan CRS; 2,4,6-triiodo-5-[methyl-[3-[methyl-[2,4,6-triiodo-3,5-bis(1,3,4-trihydroxybutan-2-ylcbamoyl)phenyl]amino]-3-oxo-propanoyl]amino]-N1,N3-bis(1,3,4-trihydroxybutan-2-yl)benzene-1,3-dicboxamide; Isovist; Iotrolan //BP; IOTROLAN; 5,5'-[(1,3-Dioxo-1,3-propanediyl)bis(methylimino)]bis[N,N'-bis[2,3-dihydroxy-1-(hydroxymethyl)propyl]-2,4,6-triiodo-1,3-benzenedicboxamide]; 2,4,6-triiodo-5-[methyl-[3-oxo-3-[2,4,6-triiodo-N-methyl-3,5-bis(1,3,4-trihydroxybutan-2-ylcbamoyl)anilino]propanoyl]amino]-1-N,3-N-bis(1,3,4-trihydroxybutan-2-yl)benzene-1,3-dicboxamide; 5-[[3-[3,5-bis[(2,3-dihydroxy-1-methylol-propyl)cbamoyl]-2,4,6-triiodo-N-methyl-anilino]-3-keto-propanoyl]-methyl-amino]-N,N'-bis(2,3-dihydroxy-1-methylol-propyl)-2,4,6-triiodo-isophthalamide; iotrolan; Compound ZK; 1,3-Benzenedicboxamide, 5,5'-[(1,3-dioxo-1,3-propanediyl)bis(methylimino)]bis[N,N'-bis[2,3-dihydroxy-1-(hydroxymethyl)propyl]-2,4,6-triiodo; IOTROLAN(ISOVIST)

物化性质

• 密度: 2.316 g/cm3
• 沸点: 1390.4ºC at 760 mmHg
• 分子式: C₃₇H₄₈I₆N₆O₁₈
• 分子量: 1626.23
• 精确质量: 1625.73000
• PSA: 399.78000
• 折射率: 1.761
• 储存条件: 2-8°C
• 水溶解性: Very soluble in water, freely soluble in dimethyl sulfoxide, practically insoluble in ethanol (96 per cent).

生物活性

• 描述: Iotrolan 是一种传统的造影剂。Iotrolan 对 NP 细胞活力没有影响或诱导细胞凋亡。
• 相关类别:
  研究领域 >> 其他
  信号通路 >> 其他 >> 其他
• 参考文献:

  [1]. Koji Iwasaki, et al. Cytotoxic effects of the radiocontrast agent iotrolan and anesthetic agents bupivacaine and lidocaine in three-dimensional cultures of human intervertebral disc nucleus pulposus cells: identification of the apoptotic pathways.PLoS One. 2014, 9,3.

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : CZ2245000 CHEMICAL NAME : 1,3-Benzenedicarboxamide, 5,5'-((1,3-dioxo-1,3-propanediyl)bis(methylimino))bis (N,N'-bis (2,3-dihydroxy-1-(hydroxymethyl)propyl)-2,4,6-triiodo - CAS REGISTRY NUMBER : 79770-24-4 LAST UPDATED : 199612 DATA ITEMS CITED : 10 MOLECULAR FORMULA : C37-H48-I6-N6-O18 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : >32 gm/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- Volume(issue)/page/year: 18,1030,1987 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - rat DOSE/DURATION : >32 gm/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- Volume(issue)/page/year: 18,1030,1987 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : >32 gm/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- Volume(issue)/page/year: 18,1030,1987 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 27 gm/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : RADLAX Radiology. (Radiological Soc. of North America, 20th & Northampton Sts., Easton, PA 18042) V.1- 1923- Volume(issue)/page/year: 142,115,1982 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intracerebral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 2352 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- Volume(issue)/page/year: 25,815,1994 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Unreported SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 2354 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- Volume(issue)/page/year: 23,93,1992 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : >32 gm/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- Volume(issue)/page/year: 18,1030,1987 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : >32 gm/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- Volume(issue)/page/year: 18,1030,1987 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : >56 gm/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : RADLAX Radiology. (Radiological Soc. of North America, 20th & Northampton Sts., Easton, PA 18042) V.1- 1923- Volume(issue)/page/year: 142,115,1982 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Mammal - dog DOSE/DURATION : >32 gm/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- Volume(issue)/page/year: 25,815,1994